Solution growth of 3D MnO2 mesh comprising 1D nanofibres as a novel sensor for selective and sensitive detection of biomolecules

Tehseen, Bushra; Rehman, Asma; Rahmat, Muniba; Bhatti, Haq Nawaz; Wu, Aiguo; Butt, Faheem K.; Naz, Gul; Khan, Waheed S.; Bajwa, Sadia Z.

doi:10.1016/j.bios.2018.06.061

Cited by 31 publications

(17 citation statements)

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“…The different shapes of MnO 2 including NRs, NTs, NWs, NSPs, NFLs, NSs, NFs, and various other shapes can be synthesized, and also their properties are changed with the variation in shape or morphology. , Figure represents various morphologies of MnO 2 with four dimensions including 0-D, 1-D, 2-D, and 3-D. Various methods have been reported for the preparation of different morphologies of MnO 2 which include lithography, the electron beam method, templates, the precipitation method, the sol–gel method, electrospinning, as well as the electrodeposition method. , All these methods were reported as most acceptable due to their simplicity, biocompatibility, economical, and versatility points of view. The variations in crystal parameter, phase structure, and surface morphology of MnO 2 showed high catalytic activity and oxidative reactivity .…”

Section: Structure and Synthesis Of Different Morphologies Of Mno2 Na...mentioning

confidence: 99%

“…MnO 2 NFs with open structure result in higher surface area for the loading of antibodies and oxidase mimicking activity . The mesh morphology enhances the electrochemical activity of the biosensor by providing a greater surface area and, also, increases the mass transport due to its macroporous network . The flower-like nanostructure of MnO 2 (Figure I) consists of interconnected NFLs which provide desirable kinetics along with a high surface area for electrochemical biosensing.…”

Section: Structure and Synthesis Of Different Morphologies Of Mno2 Na...mentioning

confidence: 99%

“…Among various transition metal oxides, manganese oxide (MnO 2 ) has been broadly considered as an active material for the detection of biomolecules because of its unique physical, optical, and electrochemical properties. MnO 2 has obtained great interest in various research fields due to its unique electrochemical properties, high charge transfer rate, large active surface area, nontoxic nature, and inexpensive cost . Moreover, various applications of MnO 2 nanostructures are due to their structural versatility, different oxidation states such as +2, +3, or +4 of Mn present in these nanostructures, and the coexistence of two or three valence states in the same crystalline structure .…”

Section: Introductionmentioning

confidence: 99%

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Biosensors Based on MnO₂ Nanostructures: A Review

Sohal

Maity

Shetti

et al. 2021

ACS Appl. Nano Mater.

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In recent years, a variety of biosensors based on manganese dioxide (MnO 2 ) nanostructures were used for the detection of different biomolecules. Structural versatility and different oxidation states of Mn present in MnO 2 nanostructures significantly enhance their biosensing applications. In this review, we have mainly focused on different morphologies of MnO 2 nanostructures and their role in different types of biosensors. We are elaborately discussing the electrochemical and optical-based biosensors on different morphologies of MnO 2 and their sensing techniques with proposed mechanisms. In electrochemical biosensors, various electrodes are available but there is a need for cheap, flexible, portable, and nontoxic electrodes. Therefore, we have discussed the fabrication of MnO 2 nanostructures on the surfaces of different types of electrodes and their real-time applications. MnO 2 nanomaterials are used in various optical biosensors due to their excellent light absorption properties, and they act as strong quenching agents. MnO 2 nanomaterials are termed "alternative natural enzymes" due to their significant enzyme-like activity. The study of various morphology-dependent sensing properties of MnO 2 nanostructures provides an insight into the development of many electrochemical and optical biosensors. Recently, MnO 2 based biosensors have earned great popularity as an alternative method for fast and easy detection of many biomolecules with very low detection limits.

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Section: Structure and Synthesis Of Different Morphologies Of Mno2 Na...mentioning

confidence: 99%

Section: Structure and Synthesis Of Different Morphologies Of Mno2 Na...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biosensors Based on MnO₂ Nanostructures: A Review

Sohal

Maity

Shetti

et al. 2021

ACS Appl. Nano Mater.

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“…Previously studies have shown that when the bulk materials are converted to nanoplates, it significantly enhanced their physical properties due to quantum confinement (Liang et al 2016;Bekenstein et al 2018). Certainly, the remarkable sensor performance can be attributed to the 2D morphology of the nanoplatelets which bear higher surface and the quantum confinement of electrons associated with them, which may have facilitated faster electrochemical analysis of biomarkers like glutathione (Liang et al 2016;Bekenstein et al 2018;Tehseen et al 2018).…”

Section: Sensor Studiesmentioning

confidence: 99%

Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment in vitro against HCT cell lines model

et al. 2020

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Nanotechnology provides a great opportunity to design multifunctional materials that can be applied for diverse platforms. As a case study, we prepared bismuth oxychloride nanoplatelets (BiOCl-NPLs) and used as bifunctional interfaces to bind biomarkers, selectively, as well as their biocompatibility potential was assessed. The structures were prepared by a facile and efficiently designed hydrothermal method and possess layered nanoplatelets morphology. The phase composition was investigated by XRD which is in accordance with the tetragonal structure of BiOCl. EDS confirmed the surface elemental composition, whereas, FTIR analysis validated the molecular structure of the prepared structures. BiOCl-NPLs modified interfaces were found remarkable to bind glutathione, an important disease biomarker. The material showed a significant sensing response to bind glutathione, which highlights its diagnostic applications. And the biocompatibility is investigated towards the human colorectal carcinoma cell line (HCT 116) using MTT assay in vitro. Our results showed that BiOCl-NPLs are non-cytotoxic, an important feature for biomedical use. The present study leads a pathway to design dual-functional materials for diagnostic and clinical applications.

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“…Manganese oxide (MnO 2 ) has become an active material in the field of biosensing among different transition-metal oxides due to its attractive physical and electrochemical properties . MnO 2 has exceptional light absorption capability, a high surface area, and a rapid rate of electron transfer due to which it can be used as a proficient fluorescence quencher in developing a “turn-off-on” sensing platform. , The properties of nanomaterials can be tuned by controlling their size, shape, crystallographic orientation, and morphology. , Shape control becomes the most important technique for improving the activity of nanomaterials .…”

Section: Introductionmentioning

confidence: 99%

Morphology-Dependent Performance of MnO₂Nanostructure–Carbon Dot-Based Biosensors for the Detection of Glutathione

Sohal

Maity

Basu

2021

ACS Appl. Bio Mater.

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Herein, we develop a facile, sensitive, and selective fluorescent nanosensor for the detection of glutathione (GSH). In this protocol, carbon dots (Cdots) with a fairly high quantum yield were synthesized by a microwave-assisted pyrolysis technique. Moreover, different shapes of the MnO 2 nanostructure were also prepared by the hydrothermal technique. A comparative photophysical study of different morphology-dependent Cdots@MnO 2 nanostructure-based biosensors was explored, which showed different results for the quenching values of ("turn-off") fluorescence intensity, quantum yields, electron transfer rate, and average lifetime. The structure, property, and performance of nanomaterials are interdependent. Therefore, the different shapes of MnO 2 , that is, nanoflowers (NFs), nanorods (NRs), and a mixture of NFs/NRs was prepared by the hydrothermal method owing to different specific surface areas (23−69 m 2 g −1 ) which put the impact on their sensing activity. It was observed that the variation in the different photophysical parameters of fluorescent Cdots such as quantum yield (Φ), average lifetime values [τ av (ns)], radiative (k r ) rate constant, nonradiative (k nr ) rate constant, rate of electron transfer (k ET ), the efficiency of electron transfer (Φ EET ), FRET efficiency (E), and Forster distance (R 0 ) were dependent on the different shapes of the MnO 2 nanostructure. These results indicate that the transfer of energy occurs between the Cdots and different shapes of MnO 2 nanostructures based on fluorescence resonance energy transfer at different charge-transfer rates. The recovery rate ("turn-on") of fluorescence of Cdots with the addition of GSH was obtained best for the NF structure by conversion of MnO 2 to Mn 2+ , and the limit of detection was obtained as ∼19 μM for GSH. The developed sensing probes were rapid, easy, cheap, and eco-friendly for the determination of GSH.

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Solution growth of 3D MnO2 mesh comprising 1D nanofibres as a novel sensor for selective and sensitive detection of biomolecules

Cited by 31 publications

References 45 publications

Biosensors Based on MnO₂ Nanostructures: A Review

Biosensors Based on MnO₂ Nanostructures: A Review

Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment in vitro against HCT cell lines model

Morphology-Dependent Performance of MnO₂Nanostructure–Carbon Dot-Based Biosensors for the Detection of Glutathione

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Solution growth of 3D MnO2 mesh comprising 1D nanofibres as a novel sensor for selective and sensitive detection of biomolecules

Cited by 31 publications

References 45 publications

Biosensors Based on MnO2 Nanostructures: A Review

Biosensors Based on MnO2 Nanostructures: A Review

Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment in vitro against HCT cell lines model

Morphology-Dependent Performance of MnO2Nanostructure–Carbon Dot-Based Biosensors for the Detection of Glutathione

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Product

Resources

About

Biosensors Based on MnO₂ Nanostructures: A Review

Biosensors Based on MnO₂ Nanostructures: A Review

Morphology-Dependent Performance of MnO₂Nanostructure–Carbon Dot-Based Biosensors for the Detection of Glutathione