Synthesis of BiOCl nanoplatelets as the dual interfaces for the detection of glutathione linked disease biomarkers and biocompatibility assessment in vitro against HCT cell lines model

Abstract

Nanotechnology provides a great opportunity to design multifunctional materials that can be applied for diverse platforms. As a case study, we prepared bismuth oxychloride nanoplatelets (BiOCl-NPLs) and used as bifunctional interfaces to bind biomarkers, selectively, as well as their biocompatibility potential was assessed. The structures were prepared by a facile and efficiently designed hydrothermal method and possess layered nanoplatelets morphology. The phase composition was investigated by XRD which is in accordance with the tetragonal structure of BiOCl. EDS confirmed the surface elemental composition, whereas, FTIR analysis validated the molecular structure of the prepared structures. BiOCl-NPLs modified interfaces were found remarkable to bind glutathione, an important disease biomarker. The material showed a significant sensing response to bind glutathione, which highlights its diagnostic applications. And the biocompatibility is investigated towards the human colorectal carcinoma cell line (HCT 116) using MTT assay in vitro. Our results showed that BiOCl-NPLs are non-cytotoxic, an important feature for biomedical use. The present study leads a pathway to design dual-functional materials for diagnostic and clinical applications.

Modification of Polyvinyl Chloride Composites for Radiographic Detection of Polyvinyl Chloride Retained Surgical Items

“…Bismuth oxychloride proved to be a very good candidate for fulfilling all these demands. Very good biocompatibility and negligible in vivo toxicity are discussed in [ 41 , 42 ]. Further, BiOCl is a water-insensitive material that exhibits extremely low toxicity as a result of its almost complete insolubility in aqueous solutions such as biological fluids [ 43 ].…”

Screen-printed p–n BiOCl/BiFeO3 heterojunctions for efficient photocatalytic degradation of Rhodamine B

“…13,15 Other studies report that BFO and BiOCl are both biocompatible and can be used in the medical eld for cancer treatments or to sense disease biomarkers. 16,17 Undoped BFO and BiOCl also have direct and indirect energy bandgap energies ranging between 2.1-2.5 eV (BFO) and 3.0-3.4 eV (BiOCl). 13,14,[18][19][20][21] To further increase BiOCl's visible light absorption, many strategies have been explored including elemental doping, incorporation of oxygen vacancies, addition of co-catalysts, morphology control or creation of heterostructures.…”

Controllable Synthesis of BiOCl with Z‐Scheme (001)/(110) Facet Homojunction and their Photocatalytic Killing Effect on HePG2 Cells in vitro

“…For example, BiOCl nanoplates prepared by Haleema et al . (22) were employed in the electrochemical detection of glutathione, yielding a 0.6 μ m lower limit of detection. BiOX used in PDT contributed to the ability to generate reactive oxygen species to kill cancer cells under light irradiation.…”

“…Besides that, recently BiOCl has shown remarkable potential for biomedical/ biological applications, such as biomarker and photodynamic therapy (PDT). For example, BiOCl nanoplates prepared by Haleema et al (22) were employed in the electrochemical detection of glutathione, yielding a 0.6 lM lower limit of detection. BiOX used in PDT contributed to the ability to generate reactive oxygen species to kill cancer cells under light irradiation.…”