Solute-solvent and solute-solute interactions of ibuprofen in aqueous and in aqueous solutions of urea, sodium salicylate and nicotinamide by volumetric and interferometric techniques

Singh, Sulochana; Talukdar, Malabika; Dash, Upendra Nath

doi:10.1016/j.molliq.2017.06.112

Cited by 23 publications

(5 citation statements)

References 30 publications

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“…In order to evaluate the hydrotropic capability of ILs for the dissolution of hydrophobic drugs, the solubility of ibuprofen was determined in several aqueous solutions of ILs, at various concentrations, and compared with the results obtained with conventional hydrotropes. The value obtained for the solubility of ibuprofen in water at (303.15 AE 0.50) K was (37.54 AE 0.93) mg L À1 , which is in good agreement with the literature, 60,61 ranging from 15.48 to 66.84 mg L À1 at the same temperature. All the solubility data, as well as the respective standard deviations, are presented in ESI † (Table S2).…”

Section: Resultssupporting

confidence: 89%

Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes

Sintra

Shimizu

Ventura

et al. 2018

Phys. Chem. Chem. Phys.

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The therapeutic effectiveness of a drug largely depends on its bioavailability, and thus ultimately on its aqueous solubility. Hydrotropes are compounds able to enhance the solubility of hydrophobic substances in aqueous media and therefore are extensively used in the formulation of drugs and personal care products. Recently, some ionic liquids were shown to display a strong ability to enhance the solubility of biomolecules through hydrotropy. In this work, the impact of the ionic liquid chemical structures and their concentration on the solubility of ibuprofen was evaluated and compared with the performance of conventional hydrotropes. The results obtained clearly evidence the exceptional capacity of ionic liquids to enhance the solubility of ibuprofen. [CCim][SCN] and [CCim][N(CN)] seem to be the most promising ionic liquids for ibuprofen solubilisation, where an increase in the solubility of 60- and 120-fold was observed with ionic liquid concentrations of circa 1 mol kg, respectively. Dynamic light scattering and molecular dynamics simulations were used to investigate the mechanism of the IL-mediated drug solubility and the results obtained indicate that the structure of aqueous solutions of ionic liquids and the role it plays in the formation of ionic liquid-drug aggregates is the mechanism driving the hydrotropic dissolution.

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Section: Resultssupporting

confidence: 89%

Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes

Sintra

Shimizu

Ventura

et al. 2018

Phys. Chem. Chem. Phys.

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“…Therefore, in order to gather a complete report about physicochemical components of such poorly water soluble drug for pharmaceutical systems, it is very much significant to determine the drug solubility of systematically. In continuation of our work [7], we now report the conductometric, sound velocity and surface tension values of IBP ( Fig. 1) at definite and infinite dilution in aqueous medium along with the corresponding derived parameters using conductance, sound velocity and surface tension data.…”

Section: Introductionmentioning

confidence: 93%

“…Using experimental values of density (reported in our paper [ 7]) and sound velocity of IBP in water, the surface tension ( ) values werederived at 298.15 K over the entire concentration range to study different intermolecular interactions in these systems. values were also measured for each concentration at 298.15K using Stalagmometer [12,13].…”

Section: Determination Of Surface Tensionmentioning

confidence: 99%

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

2020

Biointerface Res Appl Chem

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Medication disposal today is an alarming issue and gaining much more awareness from the consumers as well as healthcare professionals. Various molecular interactions surviving in aqueous drug systems may be considered responsible for these health hazards. This paper reports an experimental study of the various physico-chemical properties of poorly water soluble drug, ibuprofen in aqueous system. Conductance of ibuprofen been measured in aqueous medium at different concentrations and temperatures (from 298.15 K to 313.15 K), and the sound velocity and surface tension study are done only at 298.15 K. The experimental data have been analyzed to interpret different derived parameters as well some thermo-acoustical parameters. The surface tensionvalues have also been determined by means of Stalagmometer and the obtained values are compared with the values computed from sound velocity and density values. Insights obtained from the present study about different molecular interactions of ibuprofen can assist public health and waste management authorities to improve pharmaceutical resource handling and management in rural and urban areas. Determination of solubility.As IBP is very less soluble in water, for its solubility measurement an excess quantity of IBP in 100 mL of conductivity water was taken and heated for 30 minutes maintained at 50°C.

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“…The astonishing ability of cholinium salicylate, the best hydrotrope studied in this work, to increase the solubility of ibuprofen can thus be understood in light of the synergistic effect introduced in the previous paragraph. In order to better showcase this effect, the solubility of ibuprofen in aqueous cholinium salicylate is now compared against its solubility in aqueous cholinium chloride (Sintra et al [37] and this work) and aqueous sodium salicylate (Singh et al [43]). The novel data measured in this work is reported in Supporting Information and the three solubility curves are depicted in Figure 6.…”

Section: Dissolution Mechanismmentioning

confidence: 99%

“…Figure 6. Solubility enhancement of ibuprofen in aqueous solutions of cholinium salicylate ( ), sodium salicylate ( [43]), or cholinium chloride ( [37]), as a function of hydrotrope molal concentration, at (303.2 ± 0.5) K. S and S0 represent the solubility of the drug in the aqueous solution of the hydrotrope and in water, respectively. Lines are guides for the eye.…”

Section: Dissolution Mechanismmentioning

confidence: 99%