Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in neonatal sepsis

Doughty, Catherine; O'Driscoll, David N; Smith, Serena; O’Curráin, Eoin; Grant, Tim; O’Hare, F; Culliton, M.; Watson, R.W.G.; O’Neill, Amanda; Molloy, Eleanor J.

doi:10.1080/14767058.2020.1786520

Cited by 4 publications

(1 citation statement)

References 46 publications

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“…It also activates inflammatory response in presence of bacteraemia through TLR signal and releases proinflammatory mediators like IL-1b and TNF-a. into circulation [46,47]. Several studies have reported sTREM-1 role in diagnosis and prognosis of sepsis and systemic inflammation [26,[48][49][50], but its exact role in SARS-CoV-2 has not been explored.…”

Section: Utility Of Strem-1 In Sars-cov-2 Infectionmentioning

confidence: 99%

Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

Dholariya

Parchwani

et al. 2021

Ind J Clin Biochem

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The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation.converting enzyme 2 Covid-2019 Coronavirus disease 2019 DIC Disseminated intravascular coagulation ORF Open reading frame SARS-CoV-2 Severe acute respiratory syndrome coronavirus-2 sTREM-1 Soluble triggering receptor expressed on myeloid cells suPAR Soluble Urokinase-type plasminogen activator receptor TMPRSS2 Transmembrane protease, serine 2

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Section: Utility Of Strem-1 In Sars-cov-2 Infectionmentioning

confidence: 99%

Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

Dholariya

Parchwani

et al. 2021

Ind J Clin Biochem

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Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction

Wei,

Xiao,

et al. 2023

Open Life Sciences

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The diagnosis of sepsis still lacks a practical and reliable gold standard. The purpose of this study was to confirm the effect of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) combined with soluble suppression of tumorigenicity 2 (sST2) in the diagnosis of sepsis through the correlation between sTREM-1, sST2, and sequential organ failure assessment (SOFA) scores. Baseline data of 91 patients with sepsis in the intensive care unit were collected, sTREM-1 and sST2 were detected, and the correlation between markers and SOFA score was analyzed. Besides, the prognostic value of baseline and postadmission indicators for sepsis was analyzed with death as the outcome. The results showed that the expressions of sST2 and sTREM-1 in death group and survival group were higher than those in the survival group (p < 0.05). Correlation analysis showed that sST2, sTREM-1, and the joint diagnosis model had a high correlation with SOFA score (p < 0.05), but poor correlation with Acute Physiology and Chronic Health Evaluation Ⅱ score (p > 0.05). Among them, joint diagnosis model has the highest correlation. Receiver operating characteristic curve analysis showed that combined diagnosis had higher area under curve values. sTREM-1/sST2 can be better used in the diagnosis of sepsis than the single biomarker detection, and the combination of the above two biomarkers has potential application value in the detection and prognosis prediction of sepsis.

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Feasibility of phagocytes functional testing in neonatal sepsis diagnostics

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Zhirkova

Chernikova

et al. 2023

Ross. vestn. perinatol. pediatr.

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Neonatal sepsis is a problem still relevant for healthcare in Russia and worldwide due to high mortality and resistance to treatment. Generalization of infection in newborns occurs because of innate immunity deficiency that particularly leads to neutrophil and monocyte malfunction. Nowadays clinical practice of neonatal sepsis diagnostics does not include phagocytes functional testing. Purpose. The study aims at evaluating the ability of sepsis biomarkers (CRP, PCT, lactate, CD64, CD16, HLA-DR) to differentiate the pathogenesis of organ dysfunction in newborns in the ICU setting.Material and methods. We assessed the surface expression of neutrophil CD64 and CD16, as well as monocytic HLA-DR in newborn ICU patients with different genesis of multiple organ failure — sepsis, asphyxia and combined; as well as different outcomes of hospitalization in the ICU — survivors and deaths.Results. We have shown a significant increase in the neutrophil CD64 expression and a decrease in the monocytic HLA-DR in infectious and combined genesis of multiple organ failure compared with severe asphyxia; deaths were associated with reduced expression of neutrophil CD16.Conclusion. Our data could substantiate combined use of the phagocytes functional testing indicators together with conventional sepsis biomarkers in order to increase their prognostic and predictive value.

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Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in neonatal sepsis

Cited by 4 publications

References 46 publications

Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

Significance of sTREM-1 and sST2 combined diagnosis for sepsis detection and prognosis prediction

Feasibility of phagocytes functional testing in neonatal sepsis diagnostics

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