Soluble ST2 – biomarker for prognosis and monitoring in decompensated heart failure

Скворцов, А. А.; Narusov, O Yu; Muksinova, M. D.

doi:10.18087/cardio.n765

Cited by 5 publications

(2 citation statements)

References 61 publications

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“…Но он требует много времени для выполнения и поэтому не может быть использован в порядке "скорой помощи". Для этой цели разработаны экспресс методы измерения уровня биомаркеров [11], и встает вопрос о возможности их адекватного использования и замены ими ИФА в клинике неотложной кардиологии.…”

Section: результатыunclassified

Potential of NT-proBNP and sST2 rapid tests in patients with acute myocardial infarction

Ryabov,

Kruchinkina,

Vyshlov

et al. 2023

Russ J Cardiol

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Aim. To compare two methods for the determination of N-terminal pro-brain natriuretic peptide (NT-proBNP) and soluble ST2 (sST2): rapid immunochemical methods and standard enzyme immunoassay (ELISA), as well as to determine the possibility of rapid tests for determining these biomarkers in acute myocardial infarction (AMI).Material and methods. This open, non-randomized, single-center observational study included 41 patients: 20 with non-ST-elevation myocardial infarction (non-STEMI) and 21 with ST-elevation myocardial infarction (STEMI), without cardiogenic shock and active inflammatory process. During hospitalization, all patients underwent the level of NT-proBNP using an immunological fluorometric analyzer AQT90 FLEX (Radiometer, Germany) and sST2 immunological method for assessing lateral flow using an ASPECT Reader™ T2 analyzer (Critical diagnostics, USA). Then, studies of these biomarkers by standard ELISA were delayed.Results. The Spearman correlation coefficient for rapid NT-proBNP and NT-proBNP-ELISA was 0,5937 (p=0,00000087). At the same time, the proportion of patients with an NT-proBNP level >300 pg/ml in the rapid test was significantly higher than in the ELISA: 90% vs 44% (p<0,05). In a comparative analysis of two methods for sST2, the Spearman correlation coefficient for rapid sST2 and sST2-ELISA is 0,9561 (p=0,0000007). The proportions of patients with sST2 >35 ng/ml with rapid and ELISA methods did not differ significantly and amounted to 53 and 55%. Rapid NT-proBNP were significantly different between Killip I and Killip III (p=0,043): Me=1375,00 (669,00; 3140,00) vs Me=3660,00 (1815,00; 6890,00). There were no significant changes in the rapid sST2 level depending on Killip class.Conclusion. Correlations were found between rapid and ELISA methods in patients with AMI: medium in strength for NT-proBNP and strong for sST2. The proportion of patients with NT-proBNP levels >300 pg/mL in the rapid test was significantly higher than in the ELISA. Therefore, a conversion formula is needed, for which the available data are insufficient. The proportion of patients with sST2 >35 ng/ml in the rapid and ELISA methods did not differ significantly. A direct relationship between the level of rapid NT-proBNP and Killip class was found. No dependence of the level of rapid sST2 on Killip class was found.

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Section: результатыunclassified

Potential of NT-proBNP and sST2 rapid tests in patients with acute myocardial infarction

Ryabov,

Kruchinkina,

Vyshlov

et al. 2023

Russ J Cardiol

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show abstract

“…Первые работы по диагностической значимости ST2, хотя и показали повышение его концентрации у пациентов с ОСН, но при сравнительном анализе диагностическая ценность НУП превышала таковую sST2 [18]. При этом преимущество ST2 в качестве прогностического маркера было подтверждено серией исследований и мета-анализов.…”

Section: диагностика и прогнозирование снunclassified

Biomarkers in Heart Failure: Current and Future

Kozhevnikova

Belenkov

2021

Kardiologiia

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Heart failure (HF) is the ending of practically all cardiovascular diseases and the reason for hospitalization of 49% of patients in a cardiological hospital. Available instrumental diagnostic methods and biomarkers not always allow verification of HF, particularly in patients with preserved left ventricular ejection fraction. Prediction of chronic HF in patients with risk factors faces great difficulties. Currently, natriuretic peptides (NUP) are widely used for the diagnosis, prognosis and management of patients with HF and are included in clinical guidelines for diagnosis and treatment of HF. Following multiple studies, the understanding of NUP significance has changed. This resulted in a need for new biomarkers to improve the insight into the process of HF and to personalize the treatment by better individual phenotyping. In addition, current technologies, such as transcriptomic, proteomic and metabolomic analyses, provide identification of new biomarkers and better understanding of features of the HF pathogenesis. The aim of this study was to discuss recent reports on NUP and novel, most promising biomarkers in respect of their possible use in clinical practice.

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Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2

Pastushkova,

Goncharova,

Kashirina

et al. 2023

Hum Physiol

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Soluble ST2 – biomarker for prognosis and monitoring in decompensated heart failure

Cited by 5 publications

References 61 publications

Potential of NT-proBNP and sST2 rapid tests in patients with acute myocardial infarction

Potential of NT-proBNP and sST2 rapid tests in patients with acute myocardial infarction

Biomarkers in Heart Failure: Current and Future

Influence of Factors of 21-Day Head-Down Bed Rest on the Blood Level of Myocardial Extensibility Biomarker ST2

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