Soluble squalamine tablets for the rapid disinfection of home nebulizers of cystic fibrosis patients

Abstract

Our results suggest that aminosterol derivatives may be used by CF patients for rapid and easy home nebulizer disinfection and that soluble tablets may be developed for this purpose.

An evaluation of different steam disinfection protocols for cystic fibrosis nebulizers

“…Steam disinfection is a very potent method for killing bacteria [11][12][13]. It reduces bacterial populations more effectively and is less complicated than other methods [14,15]. In comparison, chemical disinfection requires preparation of a solution which is a risk, both for contamination and faulty measurement.…”

Synthesis and Biological Activities of Naturally Functionalized Polyamines: An Overview

“…First, squalamine was used as disinfecting agent for home nebulizer of cystic fibrosis patients, in form of a soluble tablet and disinfection can be achieved against both Gram-positive and Gram-negative bacteria and also fungi C. albicans in 20 min, whereas 6 h are needed for the fungi A. niger. [108] In a second application, squalamine delivered by aerosolization was demonstrated to reduce, in a P. aeruginosa animal infected model, the lung bacterial load and bronchopneumonia-induced histological lesions with an efficiency comparable to that encountered for colistin. [109] Finally, a squalamine 1% ointment applied in a S. aureus skin decolonization model lead to a reduction of viable bacteria by 4 log in 1 h with a single application whereas a reduction 1.3 log for the standard mupirocin drug was observed.…”

From Marine Metabolites to the Drugs of the Future: Squalamine, Trodusquemine, Their Steroid and Triterpene Analogues

“…In a mouse model, topical application of squalamine more effectively removes S. aureus from the skin than treatment with antiseptic mupirocin used in surgical practice [142]. Squalamine tablets have been developed to disinfect home nebulizers for patients with cystic fibrosis [143]. A squalamine concentration of 0.5 g/L 20 min is enough for disinfection.…”