Soluble silica and coral sand suppress high blood pressure and improve the related aortic gene expressions in spontaneously hypertensive rats

Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet

“…In our study, using a different model and silicon supplementation through SES, we showed a prevention of vascular and endothelial functions assessed respectively by the contractile response to the agonist phenylephrine and the relaxation induced by Ach. This could corroborate earlier results [18].…”

“…In a previous work, it was reported that, after supply of oral soluble silica or coral sand in spontaneously hypertensive rats, blood pressure was reduced, and that this supply improved the related aortic gene expression [18]. In our study, using a different model and silicon supplementation through SES, we showed a prevention of vascular and endothelial functions assessed respectively by the contractile response to the agonist phenylephrine and the relaxation induced by Ach.…”

“…Studies have shown an inverse relationship between the ingestion of silicon and the development of atherosclerosis [16,17]. Furthermore, silicon supplementation reduces hypertension and increases antihypertensive and antiatherogenic gene expression in the aorta of spontaneously hypertensive rats [18].…”

Silicon as neuroprotector or neurotoxic in the human neuroblastoma SH-SY5Y cell line

“…Si participates in the life processes of animals (Carlisle, 1972(Carlisle, , 1974 with important role in connective tissue (Carlisle, 1981). Si has been related to collagen synthesis (Carlisle, 1972), bone mineralization (Eisinger and Clairet, 1993), atherosclerosis (Schwarz, 1977), hypertension (Maehira et al, 2011), Alzheimer's disease (AD) (Candy et al, 1985;Gonzalez-Muñoz et al, 2008), as well as other biological disorders (Jurkić et al, 2013). The protective effect of Si against neurodegenerative disease is mainly based on the ability of silicic acid to act as a natural antagonist of aluminium (Al).…”

Assessment of potential toxicological aspects of dietary exposure to silicon-rich spirulina in rats

“…The importance of silicon has also been demonstrated in cardiovascular pathophysiology and especially in the prevention of atherosclerosis (Loeper et al, 1979). An inverse relationship between the ingestion of silicon and the development of atherosclerosis has been reported (Loeper et al, 1988), and in spontaneously hypertensive rats, silicon supplementation reduces hypertension and increases antihypertensive and antiatherogenic gene expressions in the aorta (Maehira et al, 2011). Thus, a supplementation may be justified in preventing these effects, especially in the case of suspicion or installation of pathologies.…”