Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet

Vidé, Joris; Virsolvy, Anne; Romain, Cindy; Ramos, Jeanne; Jouy, Nicolas; Richard, Sylvain; Cristol, Jean‐Paul; Gaillet, Sylvie; Rouanet, Jean-Max

doi:10.1016/j.nut.2015.03.014

Cited by 30 publications

(23 citation statements)

References 33 publications

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“…Similar results have been obtained by our group when Sp and Sp+Si supplements were tested in obesogenic diet‐fed rats (Vide et al, ). This is also in agreement with our previous study performed on Syrian hamsters, where we reported that supplementation with Sp, enriched or not, provided no protection against liver steatosis (Vidé, Virsolvy, et al, ). However, Yigit et al () have reported that Sp supplementation reduced serum cholesterol and triglyceride levels in rats fed a high‐fat diet to near control levels, with a decrease in the apoptotic index in the groups fed a high fat or a basic diet when supplemented with Sp.…”

Section: Discussionsupporting

confidence: 93%

“…Rare are the studies concerning Sp effect on glucose intolerance in Zucker or in obesogenic diet‐fed rats. In a recent study, Vidé, Virsolvy, et al () have fed syrian hamsters for 12 weeks with an atherogenic diet containing 10% hydrogenated coconut oil and 2 g/kg cholesterol. They reported that Sp intake decreased blood insulin level, whereas blood glucose remained unchanged.…”

Section: Discussionmentioning

confidence: 99%

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Effect of spirulina and silicon‐enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats

et al. 2019

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The use of Spirulina platensis (Sp) as a functional food was suggested decades ago. Biological incorporation of Silicon (Si) into Sp increases its bioavailability for potential food supplement applications. This work aimed at determining the effects of Sp and Si‐enriched Sp (Sp+Si) on metabolic syndrome features in Zucker fatty rats. Thirty Zucker fatty rats were divided into three groups and supplemented with placebo or Sp or Sp+Si croquettes for 12 weeks. Food consumption, glucose intolerance, hepatic steatosis, and mitochondrial and oxidative stress were determined. Zucker fatty rats exhibited several hepatic metabolic alterations as well as mitochondrial and oxidative stress perturbations. The intake of Sp increased plasma TG levels and decreased the hepatic NADPH oxidase activity and ameliorated transitorily the glucose intolerance. However, Si‐spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets, or durations of diet intake should be undertaken to confirm or infirm these results. Practical applications Glucose intolerance and hepatic steatosis, two major components of metabolic syndrome, are increasing and becomes a major public health issue. Use of Spirulina platensis (Sp) as a functional food was suggested as a protein‐dense food source. Bioavailable silicon (Si) may be an essential nutrient for higher animals, including humans. Sp but not Sp+Si decreased liver NADPH oxidase activity and improved transitorily glucose tolerance. This is the first study where Sp and Sp+Si effect on glucose intolerance is reported in Zucker rat. Other experiments should be undertaken to confirm or infirm invalidate the beneficial effects of Sp+Si supplement in the metabolic syndrome features.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of spirulina and silicon‐enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats

et al. 2019

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“…It also contains many photosynthetic pigments (phycocyanobilin chlorophyll and xanthophyll phytopigments) as reported by Gong et al (2005); Bermejo et al (2008), that makes SA a promising new dietary resource supporting the future production requirements of animals. The SA has various biological activities, impact effects as antioxidant (Kurd and Samavati, 2015), anti-inflammatory (Vide et al, 2015), antiviral, immune-modulatory (Sahan et al, 2015), antitumor (Konickova et al, 2014) and probiotics (Shanmugapriya et al, 2015) properties. In addition, SA is believed to reduce toxicity, increase palatability and digestibility, and protected many organs against many drugs and toxic chemicals (Abdel-Daim et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Spirulina Platensis on Reproductive Performance of Rabbit Bucks

Fouda

Ismail

2017

Egyptian Journal of Nutrition and Feeds

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his study was designed to investigate reproductive performance of adult New Zealand White (NZW) rabbit bucks as affected by oral administration of Spirulina platensis (S. platensis). Bucks were randomly distributed into 2 homogeneous groups (10 in each). The first group were orally received 3 ml distilled water (control), while those in the second group were orally treated with 3 ml distilled water containing S. platensis at a level of 700 mg/buck as daily oral for 5 weeks before semen collection period. Semen was collected twice weekly for 10 successive weeks by artificial vagina. On day of semen collection, reaction time (RT) and physical semen characteristics were determined. During the last week of collection, concentration of testosterone in blood serum (STC), and some biochemicals and antioxidant activity in seminal plasma were estimated. Results showed that the S. platensis orally administration bucks improved (P<0.01) LBW, testicular (P<0.001) and epididymal (P<0.01) weights, testicular length (P<0.01) and STC (P<0.001), and decreased RT (P<0.01) of bucks as compared to controls. Ejaculate volume and percentages of progressive sperm motility, livability, normality, and acrosomal damage as well as sperm cell concentration and total sperm output (motile, motile normal, motile live and total functional) significantly improved by S. platensis compared with controls. Also, semen pH value decreased (P<0.05) by S. platensis treatment. Concentrations of total fructose and total proteins were significantly higher in seminal plasma as affected by S. platensis treatment, while, concentrations of albumin (AL), globulin (GL) and AL: GL ratio were not affected by S. platensis treatment. Activity of total antioxidant capacity, glutathione S-transferase, superoxide dismutase, and glutathione peroxidase significantly increased, while TBARS concentration significantly decreased in seminal plasma of bucks treated with S. platensis, however, glutathione concentration was not affected. Conception rate and kindling rate, litter size and average bunny weight at birth improved in doe rabbits mated with bucks treated with S. platensis. In conclusion, S. platensis at a level of 700 mg/buck as oral administration for 5 weeks period to be used in natural mating or artificial insemination is recommended to be serving as a supportive treatment in the nutritional management to improve semen production of rabbit bucks, and fertility of doe rabbits mated with these bucks.

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“…Hamster is reported to develop the hyperlipidemic condition as early as seven days (Singh et al 2013) to two weeks of feeding (Ioriya et al 2002;Takenaga et al 2000) with HFHC diet. Additionally, researchers have also reported the ability of this model to develop the fatty streak in the aorta as early as 10 weeks (Asami et al 1999;Huang et al 2015;Vinson et al 2001;Vinson et al 2002) to 12 weeks (Auger et al 2005;Kowala et al 1995a;Vide et al 2015) of feeding with HFHC diet. The percentage of fat and cholesterol added to the diet, as well as the diet duration, is important in the design of a disease model.…”

Section: The Golden-syrian Hamster As Hyperlipidemia and Atheroscleromentioning

confidence: 96%

Coconut Oil and Cholesterol as Challenge Agents to Induce Hyperlipidemia and Atherosclerosis in Hamster Animal Model

Naina-Mohamed¹

2018

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ABSTRAKHiperlipiedmia adalah keadaan paras lipid tinggi dalam plasma dan sering dikaitkan dengan pemendapan titisan lipid dalam aorta yang menyebabkan kejadian aterosklerosis. Aterosklerosis adalah penyakit kardiovaskular yang bermula dengan pembentukan sel-sel busa di dalam dinding vascular, seterusnya menyebabkan aliran darah bergelora, kecederaan pada lapisan endotelial dan trombosis pada pembuluh darah. Sejak awal 1980-an, hamster Golden-Syrian telah digunakan secara meluas sebagai model haiwan dalam penyelidikan hiperlipiedmia dan aterosklerosis. Penggunaan hamster sebagai model hiperlipiedmia dan aterosklerosis adalah kerana profil lipoprotein mereka yang lebih dekat dengan penetapan manusia, sensitif terhadap diet tinggi-lemak tinggi-kolesterol (TLTK) dan model roden yang sesuai. Aterosklerosis boleh dicetus ke atas hamster melalui cabaran diet TLTK. Selama beberapa dekad, minyak kelapa (MK) biasa digunakan sebagai sumber lemak dalam reka bentuk diet berkomposisi asid lemak tepu tinggi (ALT). Dalam ulasan ini, kami merumuskan literatur yang diterbitkan dengan reka bentuk yang melibatkan MK-dan kolesterol-cetusan hiperlipidmia, aterosklerosis atau kedua-duanya. Faktor-faktor yang mungkin mempengaruhi kebolehan campuran MK dan kolesterol untuk menggalakkan hiperlipiedmia seperti tempoh diet, jenis hamster dan jumlah pemakanan akan dinilai dan diringkaskan. ABSTRACTHyperlipidemia is a condition of high lipid levels in the plasma and often linked with the deposition of lipid droplets in the aorta which initiate the progression of atherosclerosis. Atherosclerosis is a common cardiovascular disorder initiated by the formation of foams cells in the vascular wall which leads to turbulent blood flow, injury to the endothelial layer and subsequent vascular thrombosis. Since the early 1980's, Golden-Syrian hamsters have been widely used as an animal model in the research of hyperlipidemia and atherosclerosis. The use of hamsters in the hyperlipidemic and atherosclerotic model is due to their lipoprotein profile that is closer to human setting, sensitive to high-fat high-cholesterol (HFHC) diet and a suitable rodent model. Atherosclerosis can be induced in hamsters through dietary challenge with HFHC diet. Over the decades, coconut oil (CNO) was commonly used as the source of fat in the diet design of high saturated fatty acids (SFA) composition. In this review, we summarized published literature with designs involving CNO plus cholesterol-induced hyperlipidemia, atherosclerosis or both. The factors that may influence the ability of CNO and cholesterol combination to induce hyperlipidemia such as the period of dietary intervention, hamster strains and the dietary amount were evaluated and summarized.

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Dietary silicon-enriched spirulina improves early atherosclerosis markers in hamsters on a high-fat diet

Abstract: SES protects against metabolic imbalance, inflammation, oxidative stress, and vascular dysfunction induced by an HF diet, and could prevent the atherogenic processes. Synergistic effects between spirulina and silicon were observed.

Cited by 30 publications

References 33 publications

Effect of spirulina and silicon‐enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats

Effect of spirulina and silicon‐enriched spirulina on metabolic syndrome features, oxidative stress and mitochondrial activity in Zucker fatty rats

Effect of Spirulina Platensis on Reproductive Performance of Rabbit Bucks

Coconut Oil and Cholesterol as Challenge Agents to Induce Hyperlipidemia and Atherosclerosis in Hamster Animal Model

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