Soluble phosphate glasses: in vitro studies using human cells of hard and soft tissue origin

Bitar, Malak; Salih, Vehid; Mudera, Vivek; Knowles, Jonathan C.; Lewis, Mark P.

doi:10.1016/j.biomaterials.2003.08.054

Cited by 118 publications

(112 citation statements)

References 23 publications

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“…The solubility of phosphate glasses and the possibility of producing them in bulk, powder, porous scaf-fold or flexible fibre forms make them suitable for the design of resorbable biomedical devices for both hard and soft tissue regen-eration [3]. These glasses have been studied for bone tissue regen-eration in powder and porous scaffold forms or in composite materials [4][5][6][7][8][9], for application in the hard-soft tissue interface such as the ligament-tendon/bone attachment defects [10][11][12]. In addition, resorbable and flexible phosphate glass fibres are attractive materials for soft tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

et al. 2012

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“…Furthermore, PBGs containing calcium and sodium are both biocompatible and bioresorbable. [7] Since the release of active ions incorporated into the glass structure is controlled by the overall dissolution rate of the glass, which is often linear with time, this system has been extensively studied over recent years for use in controlled-delivery devices for biomedical applications. [8] PBGs containing Cu and Ag ions have been investigated as antimicrobial agents;…”

Section: Introductionmentioning

confidence: 99%

Preparation, structural characterisation and antibacterial properties of Ga-doped sol–gel phosphate-based glass

et al. 2009

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A sol-gel preparation of Ga-doped phosphate-based glass with potential application in antimicrobial devices has been developed. Samples of composition (CaO) 0.30 (Na 2 O) 0.20-x (Ga 2 O 3 ) x (P 2 O 5 ) 0.50 where x = 0 and 0.03 were prepared, and the structure and properties of the gallium-doped sample compared with those of the sample containing no gallium. Analysis of the 31 P MAS NMR data demonstrated that addition of gallium to the sol-gel reaction increases the connectivity of the phosphate network at the expense of hydroxyl groups. This premise is supported by the results of the elemental analysis which showed that the gallium-free sample contains significantly more hydrogen and by FTIR spectroscopy, which revealed a higher concentration of OH groups in that sample. Ga K-edge EXAFS and XANES data revealed that the gallium ions are coordinated by six oxygen atoms. In agreement with the X-ray absorption data, the high-energy XRD results also suggest that the Ga 3+ ions are octahedrally coordinated with respect to oxygen. Antimicrobial studies demonstrated that the sample containing Ga 3+ ions had significant activity againstStaphylococcus aureus compared to the control.

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“…The degradation can also be reduced by an increase of the cross-linkage or the introduction of highly insoluble ions, which makes the glass structure less susceptible to solution attack [8]. Reducing the degradation in turn has led to better biocompatibility [9], for instance, an enhanced bone cell growth together with an up regulation of antigen expression has been observed [10]; in addition, a minimal inflammatory response was also induced by the extracts of low soluble glasses [11,12].…”

Section: Introductionmentioning

confidence: 99%

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

Neel

Chrzanowski

Valappil

et al. 2009

Journal of Non-Crystalline Solids

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a b s t r a c tThis study investigates the effect of doping a high calcium oxide containing metaphosphate glass series (CaO) 40 (Na 2 O) 10 (P 2 O 5 ) 50 with TiO 2 (1, 3, and 5 mol%). TiO 2 incorporation increased the density and glass transition temperature while reduced the degradation rate (5 mol% in particular) by twofold compared with (CaO) 30 system reported previously. This has been confirmed by ion release and the minimal pH changes. TiP 2 O 7 , NaCa(PO 3 ) 3 and CaP 2 O 6 phases were detected for all TiO 2 -containing ceramics. XPS showed that the surface is composed of Ca, P, and Ti. Ti was recognized mainly as TiO 2 , but its total amount was lower than theoretical values. 31 P magic angle spinning (MAS) NMR showed a downfield shift of the 31 P lineshape with increasing TiO 2 , interpreted as an effect of the titanium cation rather than an increase in the phosphate network connectivity. FTIR showed that incorporation of TiO 2 increased the strength of the phosphate chains, and the O/P ratio while introducing more Q 1 units into the structure at the expense of the Q 2 units. There were no differences, however, in surface topography roughness and free energies between these glasses. These results suggested that TiO 2 and CaO were acting synergistically in producing glasses with controllable bulk and structural properties.

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Soluble phosphate glasses: in vitro studies using human cells of hard and soft tissue origin

Cited by 118 publications

References 23 publications

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

Phosphate glass fibres and their role in neuronal polarization and axonal growth direction

Preparation, structural characterisation and antibacterial properties of Ga-doped sol–gel phosphate-based glass

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

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