Soluble intercellular adhesion molecule-1 in patients with lung cancer and benign lung diseases

Sprenger, A.; Schardt, Cordula; Rotsch, Martin; Zehrer, Monika; Wolf, M.; Havemann, K.; Heymanns, Jochen

doi:10.1007/s004320050117

Cited by 23 publications

(18 citation statements)

References 23 publications

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“…In the present study, sICAM‐1 was the only parameter that was significantly elevated in EBC on day −1 in the test group compared with controls. sICAM‐1 in serum is associated with malignant tumours; and although it is a non‐specific marker, it may have prognostic predictive value 25,26 …”

Section: Discussionmentioning

confidence: 99%

“…sICAM-1 in serum is associated with malignant tumours; and although it is a non-specific marker, it may have prognostic predictive value. 25,26 The exclusion of patients with concomitant inflammatory diseases or other potentially stimulating factors from the present study, excluded false increased measurements of mediators. The nonspecific marker CRP was examined as a marker of the inflammatory response.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma

Jungraithmayr¹,

Frings²,

Zissel

et al. 2008

Respirology

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma

Jungraithmayr¹,

Frings²,

Zissel

et al. 2008

Respirology

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“…Furthermore, the soluble form, sICAM-1, enhances the pro-metastatic phenotype and the pro-inflammatory and pro-tumoral signaling (45). sICAM-1 has been demonstrated to be elevated in the serum of patients with liver metastasis from lung or gastric cancer (46,47), and has been identified as a marker for metastatic stage, disease recurrence and prognosis in non-Hodgkin's lymphoma, hepatocellular carcinoma (HCC), lung cancer, and other cancer types (48)(49)(50).…”

Section: Icam-1 In Liver Metastasismentioning

confidence: 99%

Role of liver ICAM-1 in metastasis

2017

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Abstract. Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig-like domains, a transmembrane domain and a short cytoplasmic tail. ICAM-1 is expressed in various cell types, including endothelial cells and leukocytes, and is involved in several physiological processes. Furthermore, it has additionally been reported to be expressed in various cancer cells, including melanoma, colorectal cancer and lymphoma. The majority of studies to date have focused on the expression of the ICAM-1 on the surface of tumor cells, without research into ICAM-1 expression at sites of metastasis. Cancer cells frequently metastasize to the liver, due to its unique physiology and specialized liver sinusoid capillary network. Liver sinusoidal endothelial cells constitutively express ICAM-1, which is upregulated under inflammatory conditions. Furthermore, liver ICAM-1 may be important during the development of liver metastasis. Therefore, it is necessary to improve the understanding of the mechanisms mediated by this adhesion molecule in order to develop host-directed anticancer therapies.

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“…11,16 In the study of Sprenger et al, the re was an in cre a se of sI CAM-1 ex pres si on du ring the prog res si on of di se a se co inci ded a po o rer sur vi val prog no sis in the pa ti ents with stab le or fal ling sI CAM-1 le vels. 27 We al so found that sI CAM-1 and VEGF le vels we re hig her in pa ti ents with ad van ced di se a se when compared to pa ti ents with early di se a se.…”

Section: Discussionmentioning

confidence: 70%

The Role of Serum Adhesion Molecules and Vascular Endothelial Growth Factor in Lung Cancer Patients

Yurdakul¹,

Han²,

Bukan³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Matrix metalloproteinase (MMP) and vascular endothelial growth factor (VEGF) which are involved in anjiogenesis and serum intercellular adhesion molecule (sICAM) which is a transmembranous protein from the immunoglobulin family play important role in tumor progression. The aim of this study was to analyze the association of serum levels of MMP-9, MMP-13, VEGF and sICAM with clinical parameters and survival in patients with non-small-cell lung cancer (NSCLC), and to determine whether these proteins might be useful tumor markers for lung cancer. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In our study, serum levels of MMP-9, MMP-13, VEGF and sICAM were analysed in 72 patients with NSCLC patients (mean age: 60.03±10.86) and 46 healthy controls (mean age: 61.13 ± 14.71). The analysis was performed by enyzme-linked immunosorbent assay (ELISA). R Re es su ul lt ts s: : The median survival of all patients was 22 months. Serum levels of sICAM, VEGF and MMP-9 were increased in NSCLC patients (985 ± 489.4, 248.7±255.9, 5148.2±1996.2) compared with the healthy controls (300.5 ± 204.1, 182.1 ± 207.5, 2943.6 ± 851.7), whereas MMP-13 levels were not significantly different from healthy control group (0.46 ± 0.48, 0.53 ± 1.35) (p> 0.05). No statistically significant relationships were found between all investigated serum parameters and age, smoking, Eastern Cooperative Oncology Group performance status, or gender (p> 0.05). Additionally, there was no significant association between all serum parameters levels and survival in NSCLC patients (p> 0.05). C Co on nc cl lu us si io on n: : High levels of MMP-9, VEGF and sICAM were found in NSCLC patients, however there was no statistically significance in MMP-13 levels. Analysis of serum levels of MMP-9, VEGF and sICAM appears as a potential tumor marker. K Ke ey y W Wo or rd ds s: : Vascular endothelial growth factors; lung; matrix metalloproteinases; intercellular adhesion molecule-1 Ö ÖZ ZE ET T A Am ma aç ç: : Anjiogenezis içinde yer alan matriks metalloproteinaz (MMP) ile vasküler endotelyal büyüme faktörü (VEGF) ve immunglogulin ailesi içinde yer alan transmembranöz bir protein olan dolaşımdaki intersellüler adezyon molekülleri (sICAM) tümör progresyonunda önemli rol oynar. Bu çalışmanın amacı, küçük hücreli dışı akciğer kanserli (KHDAK) hastalarda tedavi öncesi ölçülen MMP-9, MMP-13, VEGF ve sICAM serum düzeyleri ile hastaların klinik parametreleri ve yaşam süreleri arasındaki ilişkiyi analiz etmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmamızda 72 KHDAK'li hasta (ort. yaş: 60.03 ± 10.86) ile 46 sağlıklı kontrol grubunda (ort. yaş: 61.13 ± 14.71) MMP-9, MMP-13, VEGF ve sICAM serum düzeyleri analiz edildi. Analizler ELİSA yöntemi ile yapıldı. B Bu ul lg gu ul la ar r: : KHDAK'li hastaların medyan yaşam süresi 22 ay olarak bulundu. MMP-9, VEGF ve sICAM serum seviyeleri sağlıklı kontrol grubu (300.5 ± 204.1, 182.1 ± 207.5, 2943.6 ± 851.7) ile karşılaştırıldığında, KHDAK'li hastalarda ...

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Soluble intercellular adhesion molecule-1 in patients with lung cancer and benign lung diseases

Cited by 23 publications

References 23 publications

Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma

Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma

Role of liver ICAM-1 in metastasis

The Role of Serum Adhesion Molecules and Vascular Endothelial Growth Factor in Lung Cancer Patients

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