The Role of Serum Adhesion Molecules and Vascular Endothelial Growth Factor in Lung Cancer Patients

Abstract

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Matrix metalloproteinase (MMP) and vascular endothelial growth factor (VEGF) which are involved in anjiogenesis and serum intercellular adhesion molecule (sICAM) which is a transmembranous protein from the immunoglobulin family play important role in tumor progression. The aim of this study was to analyze the association of serum levels of MMP-9, MMP-13, VEGF and sICAM with clinical parameters and survival in patients with non-small-cell lung cancer (NSCLC), and to determine whether these proteins might be useful tumor markers for lung cancer. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In our study, serum levels of MMP-9, MMP-13, VEGF and sICAM were analysed in 72 patients with NSCLC patients (mean age: 60.03±10.86) and 46 healthy controls (mean age: 61.13 ± 14.71). The analysis was performed by enyzme-linked immunosorbent assay (ELISA). R Re es su ul lt ts s: : The median survival of all patients was 22 months. Serum levels of sICAM, VEGF and MMP-9 were increased in NSCLC patients (985 ± 489.4, 248.7±255.9, 5148.2±1996.2) compared with the healthy controls (300.5 ± 204.1, 182.1 ± 207.5, 2943.6 ± 851.7), whereas MMP-13 levels were not significantly different from healthy control group (0.46 ± 0.48, 0.53 ± 1.35) (p> 0.05). No statistically significant relationships were found between all investigated serum parameters and age, smoking, Eastern Cooperative Oncology Group performance status, or gender (p> 0.05). Additionally, there was no significant association between all serum parameters levels and survival in NSCLC patients (p> 0.05). C Co on nc cl lu us si io on n: : High levels of MMP-9, VEGF and sICAM were found in NSCLC patients, however there was no statistically significance in MMP-13 levels. Analysis of serum levels of MMP-9, VEGF and sICAM appears as a potential tumor marker. K Ke ey y W Wo or rd ds s: : Vascular endothelial growth factors; lung; matrix metalloproteinases; intercellular adhesion molecule-1 Ö ÖZ ZE ET T A Am ma aç ç: : Anjiogenezis içinde yer alan matriks metalloproteinaz (MMP) ile vasküler endotelyal büyüme faktörü (VEGF) ve immunglogulin ailesi içinde yer alan transmembranöz bir protein olan dolaşımdaki intersellüler adezyon molekülleri (sICAM) tümör progresyonunda önemli rol oynar. Bu çalışmanın amacı, küçük hücreli dışı akciğer kanserli (KHDAK) hastalarda tedavi öncesi ölçülen MMP-9, MMP-13, VEGF ve sICAM serum düzeyleri ile hastaların klinik parametreleri ve yaşam süreleri arasındaki ilişkiyi analiz etmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmamızda 72 KHDAK'li hasta (ort. yaş: 60.03 ± 10.86) ile 46 sağlıklı kontrol grubunda (ort. yaş: 61.13 ± 14.71) MMP-9, MMP-13, VEGF ve sICAM serum düzeyleri analiz edildi. Analizler ELİSA yöntemi ile yapıldı. B Bu ul lg gu ul la ar r: : KHDAK'li hastaların medyan yaşam süresi 22 ay olarak bulundu. MMP-9, VEGF ve sICAM serum seviyeleri sağlıklı kontrol grubu (300.5 ± 204.1, 182.1 ± 207.5, 2943.6 ± 851.7) ile karşılaştırıldığında, KHDAK'li hastalarda ...