Soluble human CD83 ameliorates lupus in NZB/W F1 mice

Starke, Charlotte; Steinkasserer, Alexander; Voll, Reinhard; Zinser, Elisabeth

doi:10.1016/j.imbio.2013.06.002

Cited by 25 publications

(19 citation statements)

References 24 publications

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“…Understanding the effects of specific immune modulating interventions can elucidate definitive molecular or cellular checkpoints of the complex inflammatory networks which modulate autoimmune diseases. Given the important role of CD83 for immune responses to non-self, it is not surprising that there are several reports of CD83 being involved in autoimmune processes (38,39,55,(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110). A recent report summarized immune-modulating functions of sCD83 therapy in models of multiple sclerosis, autoimmune uveitis and systemic lupus erythematosus (3).…”

Section: Autoimmunitymentioning

confidence: 99%

The CD83 Molecule – An Important Immune Checkpoint

et al. 2020

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The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed that CD83 is not a typical co-stimulatory molecule, but rather plays a critical role in controlling and resolving immune responses. Moreover, CD83 is an essential factor during the differentiation of T and B lymphocytes, and the development and maintenance of tolerance. The identification of its interaction partners as well as signaling pathways have been an enigma for the last decades. Here, we report the latest data on the expression, structure, and the signaling partners of CD83. In addition, we review the regulatory functions of CD83, including its striking modulatory potential to maintain the balance between tolerance versus inflammation during homeostasis or pathologies. These immunomodulatory properties of CD83 emphasize its exceptional therapeutic potential, which has been documented in specific preclinical disease models.

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Section: Autoimmunitymentioning

confidence: 99%

The CD83 Molecule – An Important Immune Checkpoint

et al. 2020

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“…sCD83 interfered with DC maturation in vitro and inhibited DC-dependent allogeneic and peptide-specific T cell proliferation (Lechmann et al, 2001). When administered in vivo, the EC domain of CD83 prevented the induction of experimental autoimmune encephalomyelitis and other autoimmune diseases (Zinser et al, 2004; Starke et al, 2013; Eckhardt et al, 2014). Importantly, sCD83 of natural derivation is found in DC and B cell supernatants and in the serum, whereby its origin, for instance via generation of alternative transcripts or shedding from the membrane, remains to be clarified (Hock et al, 2001; Dudziak et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Rohrscheidt¹,

Petrozziello²,

Nedjic³

et al. 2016

Journal of Experimental Medicine

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“…sCD83 also inhibited the maturation of T cells and immature DCs stimulated by mature DCs ( 7 ) and the expression and release of CD83 from mature DC membranes induced by lipopolysaccharide. Moreover, the production of autoreactive antibodies was confirmed to be regulated by sCD83 ( 8 ). The expression of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in kynurenine pathway (KP) of tryptophan metabolism, was identified as the major molecular mechanism associated with the protective effects of sCD83 ( 9 ).…”

Section: Introductionmentioning

confidence: 94%

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Tan

Guo

2018

Front. Immunol.

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Many neurologic diseases are related to autoimmune dysfunction and a variety of molecules or reaction pathways are involved in the regulation of immune function of the nervous system. Soluble CD83 (sCD83) is the soluble form of CD83, a specific marker of mature dendritic cell, which has recently been shown to have an immunomodulatory effect. Indoleamine 2,3-dioxygenase (IDO; corresponding enzyme intrahepatic, tryptophan 2,3-dioxygenase, TDO), a rate-limiting enzyme of extrahepatic tryptophan kynurenine pathway (KP) participates in the immunoregulation through a variety of mechanisms solely or with the synergy of sCD83, and the imbalances of metabolites of KP were associated with immune dysfunction. With the complement of sCD83 to IDO-KP, a previously known immunomodulatory axis, this review focused on an expanded neuroimmunomodulation axis: sCD83-IDO-KP and its involvement in nervous system diseases.

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Soluble human CD83 ameliorates lupus in NZB/W F1 mice

Cited by 25 publications

References 24 publications

The CD83 Molecule – An Important Immune Checkpoint

The CD83 Molecule – An Important Immune Checkpoint

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

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