An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Li, Bo; Tan, Ge; Guo, Li

doi:10.3389/fimmu.2018.01363

Cited by 11 publications

(8 citation statements)

References 191 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, sCD83 is elevated in the sera of MS patients and its levels are negatively correlated with disease activity in these patients [ 26 ]. Given the importance of IDO-1 for the remission of MS and EAE (reviewed in [ 85 ]) and the striking data on the sCD83/IDO-1 axis (see above), it is conceivable that sCD83 secretion represents a counter-mechanism in MS pathology, acting via IDO-1.…”

Section: Clinical Relevance Of Scd83 For Therapeutic Purposesmentioning

confidence: 99%

Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation

Peckert-Maier

Royzman

Langguth

et al. 2022

IJMS

View full text Add to dashboard Cite

Chronic inflammatory diseases and transplant rejection represent major challenges for modern health care. Thus, identification of immune checkpoints that contribute to resolution of inflammation is key to developing novel therapeutic agents for those conditions. In recent years, the CD83 (cluster of differentiation 83) protein has emerged as an interesting potential candidate for such a “pro-resolution” therapy. This molecule occurs in a membrane-bound and a soluble isoform (mCD83 and sCD83, respectively), both of which are involved in resolution of inflammation. Originally described as a maturation marker on dendritic cells (DCs), mCD83 is also expressed by activated B and T cells as well as regulatory T cells (Tregs) and controls turnover of MHC II molecules in the thymus, and thereby positive selection of CD4+ T cells. Additionally, it serves to confine overshooting (auto-)immune responses. Consequently, animals with a conditional deletion of CD83 in DCs or regulatory T cells suffer from impaired resolution of inflammation. Pro-resolving effects of sCD83 became evident in pre-clinical autoimmune and transplantation models, where application of sCD83 reduced disease symptoms and enhanced allograft survival, respectively. Here, we summarize recent advances regarding CD83-mediated resolution of inflammatory responses, its binding partners as well as induced signaling pathways, and emphasize its therapeutic potential for future clinical trials.

show abstract

Section: Clinical Relevance Of Scd83 For Therapeutic Purposesmentioning

confidence: 99%

Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation

Peckert-Maier

Royzman

Langguth

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Kynurenine, the metabolite of this reaction, is associated with neuropsychiatric symptoms [ 48 ]. Therefore, the several reactions after the kynurenine conversion induce QA production which is a known neurotoxin; moreover, it also induces oxidative stress, glutamine excitotoxicity, and mitochondria dysfunction [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects—A Preliminary Study

Lalitsuradej

Sirilun

Sittiprapaporn

et al. 2022

Foods

View full text Add to dashboard Cite

Urbanization influences our lifestyle, especially in fast-paced environments where we are more prone to stress. Stress management is considered advantageous in terms of longevity. The use of probiotics for psychological treatment has a small amount of diverse proven evidence to support this. However, studies on stress management in stressed subjects using synbiotics are still limited. The present study aimed to investigate the effects of synbiotics on stress in the Thai population. A total of 32 volunteers were enrolled and screened using a Thai Stress Test (TST) to determine their stress status. Participants were divided into the stressed and the non-stressed groups. Synbiotics preparation comprised a mixture of probiotics strains in a total concentration of 1 × 1010 CFU/day (5.0 × 109 CFU of Lactobacillus paracasei HII01 and 5.0 × 109 CFU of Bifidobacterium animalis subsp. lactis) and 10 g prebiotics (5 g galacto-oligosaccharides (GOS), and 5 g oligofructose (FOS)). All parameters were measured at baseline and after the 12th week of the study. In the stressed group, the administration of synbiotics significantly (p < 0.05) reduced the negative scale scores of TST, and tryptophan. In the non-stressed group, the synbiotics administration decreased tryptophan significantly (p < 0.05), whereas dehydroepiandrosterone sulfate (DHEA-S), tumor necrosis factor-α (TNF-α), 5-hydroxyindoleacetic acid (5-HIAA), and short-chain fatty acids (SCFAs), acetate and propionate were increased significantly (p < 0.05). In both groups, cortisol, and lipopolysaccharide (LPS) were reduced, whereas anti-inflammatory mediator interleukin-10 (IL-10) and immunoglobulin A (IgA) levels were increased. In conclusion, synbiotics administration attenuated the negative feelings via the negative scale scores of TST in stressed participants by modulating the HPA-axis, IL-10, IgA, and LPS. In comparison, synbiotics administration for participants without stress did not benefit stress status but showed remodeling SCFAs components, HPA-axis, and tryptophan catabolism.

show abstract

“…Kynurenine reflects immune system activation which corresponds to tryptophan pathway modulation involving indoleamine 2,3-dioxygenase-1. This can be classified as one of the protective mechanisms against inflammation as kynurenin stimulates regulatory T-cells, which dampen the inflammation process, antiproliferative and immunosuppressive activity induced by tryptophan breakdown [ 60 , 65 , 116 ]. Increased RNA content of Faecalibacterium prausnitzii indicates the increase level of anti-inflammatory property.…”

Section: Discussionmentioning

confidence: 99%

Probiotics for Alzheimer’s Disease: A Systematic Review

et al. 2021

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common form of neurodegenerative disorders affecting mostly the elderly. It is characterized by the presence of Aβ and neurofibrillary tangles (NFT), resulting in cognitive and memory impairment. Research shows that alteration in gut microbial diversity and defects in gut brain axis are linked to AD. Probiotics are known to be one of the best preventative measures against cognitive decline in AD. Numerous in vivo trials and recent clinical trials have proven the effectiveness of selected bacterial strains in slowing down the progression of AD. It is proven that probiotics modulate the inflammatory process, counteract with oxidative stress, and modify gut microbiota. Thus, this review summarizes the current evidence, diversity of bacterial strains, defects of gut brain axis in AD, harmful bacterial for AD, and the mechanism of action of probiotics in preventing AD. A literature search on selected databases such as PubMed, Semantic Scholar, Nature, and Springer link have identified potentially relevant articles to this topic. However, upon consideration of inclusion criteria and the limitation of publication year, only 22 articles have been selected to be further reviewed. The search query includes few sets of keywords as follows. (1) Probiotics OR gut microbiome OR microbes AND (2) Alzheimer OR cognitive OR aging OR dementia AND (3) clinical trial OR in vivo OR animal study. The results evidenced in this study help to clearly illustrate the relationship between probiotic supplementation and AD. Thus, this systematic review will help identify novel therapeutic strategies in the future as probiotics are free from triggering any adverse effects in human body.

show abstract

An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase—Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases

Cited by 11 publications

References 191 publications

Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation

Tilting the Balance: Therapeutic Prospects of CD83 as a Checkpoint Molecule Controlling Resolution of Inflammation

The Effects of Synbiotics Administration on Stress-Related Parameters in Thai Subjects—A Preliminary Study

Probiotics for Alzheimer’s Disease: A Systematic Review

Contact Info

Product

Resources

About