Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: a German multi-centre study

Rebmann, Vera; Switala, Magdalena; Eue, Ines; Grosse‐Wilde, H.

doi:10.1093/humrep/deq120

Cited by 58 publications

(80 citation statements)

References 30 publications

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“…Among these, HLA-G was found to be produced by human oocytes and embryos and has been investigated in a clinical setting due to its association with successful pregnancy outcome (52). Anyway, several multicentre trials did not confirm these findings (53)(54)(55) demonstrating that HLA-G does not improve embryo selection compared to standard morphology evaluation. Due to the multifactorial nature of embryo development, the protein profiling focused on other method such as mass @ C I C E d i z i o n i I n t e r n a z i o n a l i spectrometry (MS).…”

Section: Proteomicsmentioning

confidence: 99%

Unconventional embryo selection strategies: a look into the future

Maria¹

2016

CCE

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SummaryThe assessment of an unequivocal method able to identify the embryo with the higher possibility to implant, leading to a single live birth, is crucial for the success of an infertility treatment. Standard morphology evaluation, morphokinetic analysis and preimplantation genetic screening are the more employed embryo selection strategies in reproductive medicine centers. However, the results and the applicability of these methodologies are still controversial. Therefore, there is the need to find additional technologies to clinically select developing embryos. The challenge is to set-up a predictive, not invasive, reproducible, objective and effective method able to select the best embryo. In this review, we present several unconventional methodologies of embryo evaluation, analyzing their possible future application in human reproduction.

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Section: Proteomicsmentioning

confidence: 99%

Unconventional embryo selection strategies: a look into the future

Maria¹

2016

CCE

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“…HLA-G expression is highly tissue-restricted: besides being expressed in fetal tissues, such as trophoblast cells (Rizzo et al, 2011), HLA-G constitutive expression was found in adult thymic medulla (Mallet et al, 1999), cornea (Le Discorde et al, 2003), pancreatic islets (Cervera et al, 2010) and erythroid and endothelial-cell precursors (Rebmann et al, 2010). However, HLA-G expression can be induced in cancers (Rouas-Freiss et al, 2005), transplantation (Sheshgiri et al, 2010), multiple sclerosis (Wiendl et al, 2005), inflammatory diseases and viral infections (Fainardi et al, 2011).…”

Section: Serum Human Leukocyte Antigen-g and Soluble Interleukin 2 Rementioning

confidence: 99%

Serum Human Leukocyte Antigen-G and Soluble Interleukin 2 Receptor Levels in Acute Lymphoblastic Leukemic Pediatric Patients

Motawi

Zakhary²,

Salman³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Aims and Background: Human leukocyte antigen-G and interleukin-2 receptor play pivotal roles in the proliferation of lymphocytes, and thus generation of immune responses. Their overexpression has been evidenced in different malignant hematopoietic diseases. This study aimed to validate serum soluble human leukocyte antigen-G (sHLA-G) and serum soluble interleukin-2 receptor (sIL-2R) as an additional tool for the diagnosis and follow up of acute lymphoblastic leukemia (ALL). Subjects and Methods: Both markers were determined by ELISA in the serum of 33 ALL pediatric patients before treatment and after intensification phase of chemotherapy as well as in the serum of 14 healthy donors that were selected as a control group. Results: ALL patients showed abnormal CBC and high serum lactate dehydrogenase, which were improved after chemotherapy. Also, there was a non-significant increase in serum sHLA-G in ALL patients compared with the control group. However, after chemotherapy, sHLA-G was increased significantly compared with before treatment. On the other hand, serum sIL-2R in ALL patients was increased significantly compared with the control group. After chemotherapy, sIL-2R decreased significantly compared with before treatment. Conclusions: From these results it could be suggested that measurement of serum sHLA-G might be helpful in diagnosis of ALL, while sIL-2R might be useful in diagnosis and follow-up of ALL in pediatric patients.Keywords: Soluble human leukocyte antigen-G -soluble interleukin-2 receptor -acute lymphoblastic leukemia

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“…Human embryonic tissues possess a range of proteins and mechanisms that efficiently counteract and prevent maternal cytotoxic T cell attack and thereby provide protection and immune privilege to the fetus (Clark, 2005;Fändrich, 2002;Mor & Abrahams, 2009;Parhar et al 1989;Petroff & Perchellet, 2010;Rebmann et al, 2010;Rizzo et al, 2011a;Verloes et al, 2011). Knowledge of the immunological tolerance mechanisms taking place at the feto-maternal interface in mouse and rat models have contributed to extend such findings to human cells.…”

Section: Immunological Tolerance At the Fetal-maternal Interfacementioning

confidence: 99%

“…HLA-G expression is also claimed to be associated with embryo implantation, the protection of the allogeneic fetus from the maternal immune system, and placentation (section 3; Rebmann et al, 2010;Rizzo et al, 2011a). HLA-G protein expression was found to be constitutive in hMSC and the level was not modified upon stimulation by allogenic lymphocytes in hMSC-mixed lymphocyte reaction assay (Nasef et al 2007).…”

Section: Hla-g and Lifmentioning

confidence: 99%