Immunogenicity and Immune-Modulating Properties of Human Stem Cells

Nehlin, Jan O.; Isa, Adiba; Barington, Torben

doi:10.5772/17868

Cited by 3 publications

(2 citation statements)

References 210 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We highlight clinical implications that are amenable to immune-mediated regeneration such as parasite infection and metabolic disorders as DM2, suggesting more immune targeting strategies for both tissue regeneration and immune-modulation through the use of stem cells. However, we are well aware that many studies are needed to strongly establish the role of stem cells upon immune system cells in both allogeneic and autologous settings in long-term transplantation (Aurora and Olson, 2014;Nehlin et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Toxoplasmosis Gondii Infection and Diabetes Mellitus Type 2 Treated by Using Autologous Peripheral Blood Stem Cells a Unique Case Report of a Caucasian 83 Year Old Lady

Gargiulo¹,

Pham²,

Nguyen³

et al. 2015

Biomed Res Ther

View full text Add to dashboard Cite

Abstract-Introduction:Toxoplasma gondii is an intracellular protozoan responsible for up to one-third of the world's population infestation. Diabetes is one of the most silent and threatening disease of the modern time it is constantly increasing in both industrialized and developing countries. This is a case of clinically importance for two reason, firstly it will help clinicians save a broad differential diagnosis when attending to evaluate analogous cases and secondly, it may confirm the role of autologous peripheral blood stem cells (PB-SCs) in enhancing auto-immune response against parasitic infection and in regulating insulin uptake in diabetes mellitus type 2 (DM2). Case presentation: We present a unique case of 83-year-old woman from Argentina presenting with a widespread erythema and urticaria for 5 months and DM2 as underlying condition. She was initially diagnosed with unspecific skin auto-immune disorder. By the time of visit she was complaining of constant diarrhea-constipation and general mental and physical fatigue. Conclusion: This case illustrates that toxoplasmosis can present with just simple disseminated and generalized skin erythema with severe itching and, thus can be confused with similar infectious disease such as Epstein-Barr virus (EBV), cytomegalovirus, cat scratch disease or leishmaniasis. The report emphasizes the need of correct diagnostic procedure in confusing cases, and may help to increase the awareness about the identification of this disease. This case may open to the possibility of a different approach and methodology in treatment T gondii and DM2 through the use of PB-SCs.

show abstract

Section: Resultsmentioning

confidence: 99%

Toxoplasmosis Gondii Infection and Diabetes Mellitus Type 2 Treated by Using Autologous Peripheral Blood Stem Cells a Unique Case Report of a Caucasian 83 Year Old Lady

Gargiulo¹,

Pham²,

Nguyen³

et al. 2015

Biomed Res Ther

View full text Add to dashboard Cite

show abstract

“…Because of the proven immunomodulatory properties of CS [33] and the fact that it is one of the most represented components of cartilage [60], we integrated CS into a collagen‐based scaffold to create a desirable environment for MSC to exert their protective and regenerative effects. MSCs hold an inherent immunoregulatory potential and elicit immunosuppressive effects in several situations [43]; they are able to interfere with a variety of immune cell functions (i.e., cytokine secretion and cytotoxicity of T and NK cells, B cell maturation and antibody secretion, dendritic cell maturation and activation, and well as antigen presentation) by means of direct cell‐to‐cell interactions or soluble factor secretion, such as NO and PGE 2 [61]. In this scenario, we exposed MSCs grown onto CL and CSCL to a proinflammatory environment to evaluate the capability of the system to help MSCs retain their immunosuppressive effect without inducing a material‐dependent stress.…”

Section: Discussionmentioning

confidence: 99%