“…Among intracellular pathways, the mitochondrial pathway plays an important role, because of the presence of abundant proapoptotic factors (cytochrome C, Smac, AIF, endonuclease G) in mitochondria [8,12]. The release of these factors from the intermembrane space into cytosol activates procaspase-9, thus triggering apoptosis [1]. This process is impossible without opening of permeability transition pores between the outer and inner mitochondrial membranes and formation of channels in the outer membrane, which leads to a drop of transmembrane potential [12].…”