Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

Satoh, Hiroshi; Hara, Toshiko; Murakawa, Daisuke; Matsuura, M.; Takata, Kazuyuki

doi:10.1007/s10620-009-0893-2

Cited by 28 publications

(21 citation statements)

References 26 publications

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“…We demonstrated that both the expression of COX isoforms and the levels of PGE 2 in the duodenum were increased after a meal and that the effect was suppressed by pretreatment with cimetidine, suggesting that the influx of gastric acid into the duodenum stimulates the local expression of COX isoforms and that the increase in COX isoforms contributes to the protection of mucosa through the enhanced PG synthesis during the postprandial period. We previously reported that the formation of IND-induced duodenal lesions in cats was markedly prevented by pretreatment with cimetidine or misoprostol (Satoh et al, 2009(Satoh et al, , 2010. This finding is consistent with the present results.…”

Section: Drugsupporting

confidence: 94%

Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats

Satoh

Amagase

Ebara

et al. 2012

J Pharmacol Exp Ther

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Although nonsteroidal anti-inflammatory drugs often cause ulcers in the duodenum in humans, the role of cyclooxygenase (COX) isoforms in the pathogenesis of duodenal ulcers has not been fully elucidated. We examined in cats the 1) ulcerogenic effects of selective COX-1 (SC-560, ketorolac) and COX-2 (celecoxib, meloxicam) inhibitors on the gastrointestinal mucosa, 2) effect of feeding and cimetidine on the expression of COX isoforms and prostaglandin E 2 (PGE 2 ) level in the duodenum, and 3) localization of COX isoforms in the duodenum. COX inhibitors were administered after the morning meal in cats once daily for 3 days. Gastrointestinal lesions were examined on day 4. Localization and expression of COX isoforms (by immunohistochemistry, Western blot) and PGE 2 level (by enzyme immunoassay) were examined. Results were as follows. First, selective COX-1 or COX-2 inhibitors alone produced marked ulcers in the duodenum but did not cause obvious lesions in the small intestine. Coadministration of SC-560 and celecoxib produced marked lesions in the small intestine. Second, feeding increased both the expression of COX isoforms and PGE 2 level in the duodenum, and the effects were markedly inhibited by pretreatment with cimetidine. Third, COX-1 was localized in goblet and Brunner's gland cells, Meissner's and Auerbach's plexus, smooth muscle cells, and arterioles; and COX-2 was observed in capillaries, venules, and basal granulated cells. The expression of COX isoforms in the duodenum is up-regulated by feeding, and inhibition of either COX-1 or COX-2 causes ulcers in the duodenum, suggesting that both isoforms play an important role in the protection of the duodenal mucosa.

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Section: Drugsupporting

confidence: 94%

Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats

Satoh

Amagase

Ebara

et al. 2012

J Pharmacol Exp Ther

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“…Another recent study documented that soluble dietary fibers can protect cats from indomethacin-induced small intestinal lesions; dietary fibers act same as endogenous mucin [21]. Dietary fibers may also influence enterobacteria.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gastrointestinal Adverse Effects of Ketoprofen between Adult and Young Cats

Takata

Hikasa

Satoh

2012

The Journal of Veterinary Medical Science

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ABSTRACT. This study elucidated differences in predisposition to the gastrointestinal adverse effects of ketoprofen between young and adult cats. Ketoprofen was administered subcutaneously (2.0 mg/kg, s.c.) once a day for 3 days. The animals were sacrificed 24 hr after final injection to allow examination of gastrointestinal mucosal lesions. Ketoprofen caused gastric lesions in adult cats (>6 months) but not in young cats (<3 months). Ketoprofen caused more severe small intestinal lesions in adult cats than in young cats. In the study of prevention of lipopolysaccharide (LPS)-induced hyperthermia using ketoprofen, young and adult cats of both sexes were administered LPS (0.3 µg/ kg, intravenously), and body temperature was measured 24 hr later. Ketoprofen was administered subcutaneously 30 min before LPS injection. LPS-induced hyperthermia was almost completely inhibited by pretreatment with ketoprofen in both adult and young cats. In the pharmacokinetics of ketoprofen, plasma concentrations were analyzed by high-performance liquid chromatography. No significant differences were observed in plasma concentrations of two mirror-image R(−) and S(+) ketoprofen between young and adult cats from 0.5-4 hr after injection. As observed in a previous study using flunixin, the degree of gastrointestinal damage was unrelated to plasma concentrations of ketoprofen. The results of this study demonstrated that ketoprofen is safer for use in young cats than in adult cats from the viewpoint of gastrointestinal adverse effects. KEY WORDS: gastrointestinal effect, ketoprofen, lipopolysaccharide, non-steroidal anti-inflammatory drug, pharmacokinetics.

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“…In order for a fiber to bind bile acids, it is required to be viscous in nature, and polydextrose is lower in viscosity for instance in comparison to pectin and guar gum which have high water binding capacity with higher viscosity and thus increased capability to bind bile acids [42,78]. Polydextrose has a high capacity to bind water, and it can for instance relieve constipation presumably due to this characteristic, but there is no gel formation by polydextrose in water and little viscosity [43,79,80].…”

Section: Role Of Polydextrose In Enterohepatic Bile Circulation and Imentioning

confidence: 99%

Polydextrose in Lipid Metabolism

Putaala¹

2013

Lipid Metabolism

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Soluble Dietary Fiber Protects Against Nonsteroidal Anti-inflammatory Drug-Induced Damage to the Small Intestine in Cats

Abstract: SDFs protect the small intestine against NSAID-induced damage, probably by compensating a barrier function of the mucin decreased by IND. Viscosities of the SDFs play a role, at least in part, in the protective effects of the SDFs on the small intestine.

Cited by 28 publications

References 26 publications

Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats

Cyclooxygenase (COX)-1 and COX-2 Both Play an Important Role in the Protection of the Duodenal Mucosa in Cats

Comparison of Gastrointestinal Adverse Effects of Ketoprofen between Adult and Young Cats

Polydextrose in Lipid Metabolism

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