Soluble curcumin amalgamated chitosan microspheres augmented drug delivery and cytotoxicity in colon cancer cells: In vitro and in vivo study

Jyoti, Kiran; Bhatia, Richa Kaur; Martis, Elvis A. F.; Coutinho, Evans C.; Jain, Upendra Kumar; Chandra, Ramesh; Madan, Jitender

doi:10.1016/j.colsurfb.2016.09.044

Cited by 51 publications

(15 citation statements)

References 39 publications

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“…Hence, high single doses of CUR are required to achieve detectable levels in serum of healthy volunteers [6]. Thus, different strategies were tested to overcome these limits, such as liposome-based formulations, and emulsion or microsphere preparations of CUR [7,8,9], all of which were developed with the ultimate goal of optimizing its bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

126

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Cancer patients frequently use complementary medicine. Curcumin (CUR) and its derivates (from the extract of Curcuma longa L.) represent some of the most frequently used ones, having a long history in traditional Asian medicine. CUR was demonstrated, both in vitro and in vivo, to have significant anti-inflammatory effects, thus potentially counteracting cancer-promoting inflammation, which is a hallmark of cancer. CUR modulate a plethora of signaling pathways in cancer cells, comprising the NF-κB (nuclear factor k-light-chain-enhancer of activated B cells), the JAK/STAT (Janus-Kinase/Signal Transducers and Activators of Transcription), and the TGF-β (transforming growth factor-β) pathways. Furthermore, CUR confers properties of electron receptors, which destabilize radical oxygen species (ROS), explaining its antioxidant and anti-apopototic effects. Although CUR has a low bioavailability, its role in advanced cancer treatment and supportive care was addressed in numerous clinical trials. After promising results in phase I–II trials, multiple phase III trials in different indications are currently under way to test for direct anti-cancer effects. In addition, CUR exerts beneficial effects on cancer treatment-related neurotoxcity, cardiotoxicity, nephrotoxicity, hemato-toxicity, and others. More efficient galenic formulations are tested to optimze CUR’s usability in cancer treatment. This review should provide a comprehensive overview of basic science, and pre-clinical and clinical data on CUR in the field of oncology.

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Section: Introductionmentioning

confidence: 99%

Curcumin: New Insights into an Ancient Ingredient against Cancer

Willenbacher

Khan²,

Mujica³

et al. 2019

IJMS

126

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“…In vitro experiments demonstrated that the curcumin complex-chitosan microspheres released 95.7% of their curcumin after 24 h in simulated colonic fluid. The concentration of curcumin in colon tissue was significantly higher (44.32 g/g) in mice that received 100 mg/kg of curcumin complex loaded chitosan microspheres by oral gavage than those that received unformulated curcumin (5.3 g/g) [163]. Microparticles containing a curcumin solid dispersion were prepared by the spray drying technique using Gelucire ® 50/13 (stearoyl macrogol-32 EP) and the colloidal silicon dioxide Aerosil ® as a carrier for curcumin delivery.…”

Section: Microcarriers For Curcumin Deliverymentioning

confidence: 91%

Improvement of Curcumin Bioavailability for Medical Applications

Her¹,

Venier-Julienne²,

Roger³

2018

Med Aromat Plants

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“…Wei et al 28 demonstrated that cholesteryl-hyaluronic acid nanogel of CUR exhibited excellent solubility and sustained drug release under physiological conditions and effectively inhibited human pancreatic adenocarcinoma MiaPaCa-2 cells. Jyoti et al 29 investigated chitosan (CS) microspheres of CUR and showed that the microspheres improved solubility and therapeutic index of CUR in HT-29 cells. In addition, it was reported that a series of mesoporous silica material-loaded CUR exhibited higher oral bioavailability and cellular uptake and significantly increased A549, MCF-7 and B16F10 cell apoptosis compared to CUR.…”

Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Soluble curcumin amalgamated chitosan microspheres augmented drug delivery and cytotoxicity in colon cancer cells: In vitro and in vivo study

Cited by 51 publications

References 39 publications

Curcumin: New Insights into an Ancient Ingredient against Cancer

Curcumin: New Insights into an Ancient Ingredient against Cancer

Improvement of Curcumin Bioavailability for Medical Applications

Liposomal curcumin and its application in cancer

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