Soluble adhesion molecule P-selectin and endothelial dysfunction in essential hypertension

Lip, Gregory Y.H.; Blann, Andrew D.; Zarifis, John; Beevers, M.; Lip, Peck Lin; Beevers, D. G.

doi:10.1097/00004872-199512010-00030

Cited by 70 publications

(53 citation statements)

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“…Soluble ICAM-1 and VCAM-1 have also been explored in the context of essential hypertension. [26][27][28][29][30][31] In this study, ICAM-1 and VCAM-1 concentrations before RSD were significantly higher in patients who responded to RSD. Shear stress and endothelial cell activation stimulate the expression of ICAM-1 and VCAM-1 during essential hypertension, suggesting that the endothelium is more activated in responders than in nonresponders, although baseline systolic BP did not significantly differ between responders and nonresponders.…”

Section: Discussionmentioning

confidence: 88%

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

et al. 2014

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A rterial hypertension (HT) represents a major risk factor for cardiovascular morbidity and mortality.1 HT is associated with endothelial dysfunction that aggravates progressive vascular damage and atherosclerosis.2-4 Endothelial dysfunction can be indicated by elevated serum concentrations of endothelial adhesion molecules, including intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). 5,6 These adhesion molecules play important roles in accelerating atherosclerosis by attaching inflammatory cells to the vascular endothelial wall and promoting their subsequent migration through the endothelium.The vascular endothelial growth factor and its soluble receptor fms-like tyrosine kinase-1 (sFLT-1) are also associated with endothelial dysfunction, vascular remodeling, and endothelial repair and regeneration mechanisms.7-11 Hypoxia and endothelial shear stress in HT are known to be major stimuli for sFLT-1 expression and release.12-16 Furthermore, sFLT-1 is stimulated by the vascular sympathetic nervous system and has been reported to be elevated in patients with HT. The persistence of hypertensive blood pressure (BP) in patients with resistant hypertension is partially regulated by the renal sympathetic nerve system. 17-21 Renal sympathetic denervation (RSD) is an interventional treatment option for patients who have resistant hypertension, despite optimal medical treatment. 22,23 However, RSD is not effective in ≈8% to 12% of treated patients. 22,23 Predictive parameters regarding the response or nonresponse to RSD have not yet been described.We postulated a relationship among successful RSD-related BP reduction, endothelial dysfunction, and activated endothelial cells as indicated by ICAM-1, VCAM-1, and sFLT-1, specific markers for endothelial cell activity and hypertension-related endothelial sheer stress. Therefore, the primary aim of the present study was to examine the predictive value of sFlt-1, ICAM-1, and See Editorial Commentary, pp 907-908Abstract-Renal sympathetic denervation (RSD) is a treatment option for patients with resistant arterial hypertension, but in some patients it is not successful. Predictive parameters on the success of RSD remain unknown. The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. Consecutive patients (n=55) undergoing renal denervation were included. Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. A therapeutic response was defined as an office systolic blood pressure reduction of >10 mm Hg 6 months after RSD. A significant mean office systolic blood pressure reduction of 31.2 mm Hg was observed in 46 patients 6 months after RSD. Nine patients were classified as...

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Section: Discussionmentioning

confidence: 88%

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

et al. 2014

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“…Soluble levels of some of these molecules such as E-selectin, P-selectin, ICAM-1 and VCAM-1 have been explored in essential hypertension (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). The relationship between Creactive protein (CRP) and hypertension has also been studied (27,28) wherein prevalence of hypertension was demonstrated to be high in subjects with second, third and fourth quartile of high sensitivity (hs) CRP as compared to subjects in the first quartile.…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of cell adhesion molecules in hypertension

Shalia

Mashru

Vasvani

et al. 2009

Indian J Clin Biochem

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“…30 As with membrane-bound P-selectin, sP-selectin has been shown to exert proinflammatory, 31,32 prothrombotic, 33 and procoagulant activities. 34 Elevated levels of sP-selectin are seen in patients with vascular diseases, 31,35 hypercholesterolemia, 36 hypertension, 37 unstable angina, 38 exuberated stroke, 39 and aortic valve stenosis. 40 P-selectin has been demonstrated to be a key initiator in the development of atherosclerosis via the formation of platelet-monocyte aggregates (PMA).…”

Section: P-selectinmentioning

confidence: 99%

“…61,62 Elevated levels of sP-selectin were also observed in patients with vascular disorders such as hypertension and hypercholesterolemia. 36,37 In patients with acute cerebral infarction, P-selectin and sP-selectin levels have been shown to be elevated compared to healthy individuals, and to correlate with an increase in phospholipase A 2 (PLA). 63,64 Taken together, P-selectin appears to have a correlation not only with onset of disease, but also with progression of disease and shows great promise as a cardiovascular biomarker.…”

Section: P-selectinmentioning

confidence: 99%

Incorporating biomarkers into clinical trials in cardiovascular medicine

Lee¹,

Ota²

2014

CBF

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Developing novel therapies and establishing clinical benefits over conventional therapies has become a highly competitive and a costly endeavor. In this regard, biomarkers have become increasingly important in accurately assessing both efficacy and safety of these novel therapies. While the use of biomarkers has proved vital in cardiovascular research and disease management, current established biomarkers are inadequate in capturing and accounting for the entire cardiovascular disease process and responses to therapeutic interventions. Substantial effort has been made in exploring and clinically evaluating novel biomarkers. The present review aims to shed light on some of the novel cardiovascular biomarkers being investigated, including high sensitivity C-reactive protein, proprotein convertase subtilisin/kexin type 9, P-selectin, secretory phospholipase A 2 , lipoprotein-associated phospholipase A 2 , and growth differentiation factor 15, and illustrate their relevance to clinical research.

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Soluble adhesion molecule P-selectin and endothelial dysfunction in essential hypertension

Cited by 70 publications

References 0 publications

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

Soluble fms-Like Tyrosine Kinase-1 and Endothelial Adhesion Molecules (Intercellular Cell Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) as Predictive Markers for Blood Pressure Reduction After Renal Sympathetic Denervation

Circulating levels of cell adhesion molecules in hypertension

Incorporating biomarkers into clinical trials in cardiovascular medicine

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