Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: a Review

Malik, Nisar Ahmad

doi:10.1007/s12010-016-1987-x

Cited by 60 publications

(29 citation statements)

References 129 publications

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“…This leads to an expansion of bile acid pool hetero geneity [128][129][130][131] . The detergent properties of bile acids aid fat digestion and absorption by the delivery of lipids, lipid-soluble vitamins and other hydro phobic compounds to the brush border of the intestine 132 . Furthermore, bile acids are potent signalling molecules that signal through farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (GPBAR1) and that regulate metabolism in virtually all tissues 133,134 .…”

Section: Regulation Of Food Absorptionmentioning

confidence: 99%

Diet–microbiota interactions and personalized nutrition

2019

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Conceptual scientific and medical advances have led to a recent realization that there may be no single, one-size-fits-all diet and that differential human responses to dietary inputs may rather be driven by unique and quantifiable host and microbiome features. Integration of these person-specific host and microbiome readouts into actionable modules may complement traditional food measurement approaches in devising diets that are of benefit to the individual. Although many host-derived factors are hardwired and difficult to modulate, the microbiome may be more readily reshaped by environmental factors such as dietary exposures and is increasingly recognized to potentially impact human physiology by participating in digestion, the absorption of nutrients, shaping of the mucosal immune response and the synthesis or modulation of a plethora of potentially bioactive compounds. Thus, diet-induced microbiota alterations may be harnessed in order to induce changes in host physiology , including disease development and progression. However, major limitations in 'big-data' processing and analysis still limit our interpretive and translational capabilities concerning these person-specific host, microbiome and diet interactions. In this Review , we describe the latest advances in understanding dietmicrobiota interactions, the individuality of gut microbiota composition and how this knowledge could be harnessed for personalized nutrition strategies to improve human health.

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Section: Regulation Of Food Absorptionmentioning

confidence: 99%

Diet–microbiota interactions and personalized nutrition

2019

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“…Such uniqueness is what leads to the unusual micelle structures formed upon bile salts’ self‐assembly in water, which further separates them from conventional head and tail surfactants. Various models have been proposed for bile salt micelle formation and several hypotheses have been made regarding their aggregates’ structures formed through hydrophobic interactions between the steroid nuclei of bile salts (nonpolar face) and the hydrogen bonding between the bile salts hydroxyl groups (polar face) (Malik, 2016). It was reported in previous studies that short, rod‐like micelles were formed upon combining both bile salts and lecithin in a mixture (Cheng et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…Having both a positively charged choline head group and a negatively charged phosphate group, lecithin is considered to be a zwitterionic compound that tends to self-assemble in water, forming characteristic bilayer membrane-like structures (Cheng, Oh, Wang, Raghavan, & Tung, 2014 (Malik, 2016). It was reported in previous studies that short, rod-like micelles were formed upon combining both bile salts and lecithin in a mixture (Cheng et al, 2014).…”

Section: Mixed Micellar Systemmentioning

confidence: 99%

Incorporating physiologically relevant mobile phases in micellar liquid chromatography for the prediction of human intestinal absorption

Shokry

Waters

Parkes

et al. 2018

Biomedical Chromatography

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Micellar liquid chromatography is a popular method used in the determination of a compound's lipophilicity. This study describes the use of the obtained micelle–water partition coefficient (log P mw) by such a method in the prediction of human intestinal absorption (HIA). As a result of the close resemblance of the novel composition of the micellar mobile phase to that of physiological intestinal fluid, prediction was deemed to be highly successful. The unique micellar mobile phase consisted of a mixed micellar mixture of lecithin and six bile salts, i.e. a composition matching that found in the human intestinal environment, prepared in ratios resembling those in the intestine. This is considered to be the first method to use a physiological mixture of biosurfactants in the prediction of HIA. As a result, a mathematical model with high predictive ability (R 2 PRED = 81%) was obtained using multiple linear regression. The micelle–water partition coefficient (log P mw) obtained from micellar liquid chromatography was found to be a successful tool for prediction where the final optimum model included log P mw and polar surface area as key descriptors with high statistical significance for the prediction of HIA. This can be attributed to the nature of the mobile phase used in this study which contains the lecithin–bile salt complex, thus forming a bilayer system and therefore mimicking absorption across the intestinal membrane.

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“…Consequently, they are amphiphilic and chiral compounds. In biology they are well known to facilitate fat absorption; they are signaling molecules, affecting both nuclear and membrane receptors, and are useful in various applications due to their tendency to form micelles . Originally, bile acids were intended as additives for staining solutions, suppressing the formation of dye aggregates.…”

Section: Introductionmentioning

confidence: 99%

First Report of Chenodeoxycholic Acid–Substituted Dyes Improving the Dye Monolayer Quality in Dye‐Sensitized Solar Cells

et al. 2020

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Chenodeoxycholic acid (CDCA) is the most used antiaggregation additive in dye‐sensitized solar cells since its introduction to the field in 1993. However, effective suppression of dye aggregation comes at the cost of reduced dye loading, a lower open‐circuit voltage, and limited control of dye/additive distribution when cosensitizing with free CDCA. To combat this, herein, a novel dye design concept that uses the covalent attachment of a CDCA moiety to triarylamine sensitizers is reported. The CDCA substituents do not affect the photophysical or electrochemical properties of the sensitizers but have a positive effect on the photovoltaic performance with [Cu+/2+(tmby)2](TFSI)1/2 electrolyte (tmby = 4,4′,6,6′‐tetramethyl‐2,2′‐bipyridine, TFSI = bis(trifluoromethanesulfonyl)imide). By ensuring a one‐to‐one ratio of dye and CDCA, paired with isotropic distributions of each component, this approach results in a higher‐quality dye monolayer. Compared with the reference system, the novel approach reported herein gives a higher open‐circuit voltage and power conversion efficiency (PCE). The best device is fabricated with the dye C6–CDCA, delivering a PCE of 6.84% (8 μm TiO2, 1 mm CDCA, JSC = 8.64 mA cm−2, VOC = 1007 mV, and FF = 0.77).

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Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: a Review

Cited by 60 publications

References 129 publications

Diet–microbiota interactions and personalized nutrition

Diet–microbiota interactions and personalized nutrition

Incorporating physiologically relevant mobile phases in micellar liquid chromatography for the prediction of human intestinal absorption

First Report of Chenodeoxycholic Acid–Substituted Dyes Improving the Dye Monolayer Quality in Dye‐Sensitized Solar Cells

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