Solubility of atenolol in ethanol+ water mixtures at various temperatures

Hamidi, Samin; Jouyban, Abolghasem

doi:10.2298/jsc140617095h

Cited by 4 publications

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“…The surface characteristics and SEM images of TiATN ethanol samples indicate that ATN nanocrystals covered Ti nanotubes and also that bigger ATN crystals may be found in the system. This may be explained by the phenomenon that the highest solubility of ATN can be observed in the 70 w / w % ethanol solution [27]. The fast evaporation of the ethanol content during solvent removal may induce the fast supersaturation of the solution, which can result in intensive nanocrystal formation on the surface of TNTs as nuclei.…”

Section: Resultsmentioning

confidence: 99%

“…In a previous work, 70% ethanol solution was used as a solvent to prepare composites with various drugs [25]. The selected solvent was able to improve the poor aqueous solubility of diclofenac sodium, atenolol (ATN), and hydrochlorothiazide (HCT) [26,27,28] or improve the crystallization of the highly water-soluble diltiazem HCl, while providing uniform process conditions for better comparability. Nevertheless, the result revealed that the composite formation was suboptimal for ATN and HCT.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites

et al. 2019

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Recently, there has been an increasing interest in the application of nanotubular structures for drug delivery. There are several promising results with carbon nanotubes; however, in light of some toxicity issues, the search for alternative materials has come into focus. The objective of the present study was to investigate the influence of the applied solvent on the composite formation of titanate nanotubes (TNTs) with various drugs in order to improve their pharmacokinetics, such as solubility, stability, and bioavailability. Composites were formed by the dissolution of atenolol (ATN) and hydrochlorothiazide (HCT) in ethanol, methanol, 0.01 M hydrochloric acid or in ethanol, 1M sodium hydroxide, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), respectively, and then they were mixed with a suspension of TNTs under sonication for 30 min and vacuum-dried for 24 h. The structural properties of composites were characterized by SEM, TEM, FT-IR, differential scanning calorimetry (DSC), thermogravimetric (TG) analysis, and optical contact angle (OCA) measurements. Drug release was determined from the fast disintegrating tablets using a dissolution tester coupled with a UV–Vis spectrometer. The results revealed that not only the good solubility of the drug in the applied solvent, but also the high volatility of the solvent, is necessary for an optimal composite-formation process.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites

et al. 2019

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“…Among the broad variety of methods proposed for enhancing atenolol solubility, the addition of pharmaceutic cosolvents is the most widely used technique for atenolol in aqueous media [1][2][3][4]. The solubility enhancement of poorly soluble atenolol can be achieved by the changes of temperature [5]. Solubility enhancement by using alkaline medium [6], stability of atenolol in acidic environment depending on diversified polarity [7].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

Mezaal¹

2020

IHJPAS

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Atenolol was used with povidone iodine to prove the efficiency, reliability and repeatability of the long distance chasing photometer (NAG-ADF-300-2) using continuous flow injection analysis. The method is based on reaction between atenolol and povidone iodine in an aqueous medium. Optimum parameters was studied to increase the sensitivity development of method. Calibration graph was linear in the range of 2-19 mmol/L for cell A and 5-19 mmol/L for cell B. Limit of detection 146.4848 ng/55 µL and 2.6600 µg/200 µL respectively to cell A and cell B. Correlation coefficient (r) 0.9957 for cell A and 0.9974 for cell. Relative standard deviation (RSD %) was lower than 1%, (n=8) for the determination of atenolol at concentration (5, 9 and 17) mmol/L for cell A and (5, 13 and 17) mmol/L for cell B respectively. The results were compared with classical method UV-spectrophotometric at λ max=270 nm by using method standard addition via t-test, at 95% confidence level. The comparison of data explain that long distance chasing photometer (NAG-ADF-300-2) is the choice with excellent extended detection and wide application.

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“…The SEM and OCA results of TiATNethanol samples indicate that ATN nanocrystals covered Ti nanotubes besides the existence of bigger ATN crystals in the system. This may be explained by the phenomenon that the highest solubility of ATN can be observed in the 70 w/w% ethanol solution (84). The fast supersaturation of the solution was induced by the fast evaporation of the ethanol content during solvent removal, which resulted in an intensive nanocrystal formation on the surface of TNTs as nuclei, whereas the rest of the ATN may undergo a slower crystallization process due to the slower evaporation rate of and strong H-bond based interactions with water.…”

Section: Effect Of Various Solvents On Composite Formation With Atnmentioning

confidence: 99%

The utilization of titanate nanotubes as drug delivery systems

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Solubility of atenolol in ethanol+ water mixtures at various temperatures

Cited by 4 publications

References 0 publications

Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites

Optimization of the Production Process and Product Quality of Titanate Nanotube–Drug Composites

Assessment of Long Distance Chasing Photometer (NAG-ADF-300-2) by Estimating the Drug Atenolol with Povidone Iodine Via CFIA

The utilization of titanate nanotubes as drug delivery systems

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