Solubility measurements and modeling of molecules of biological and pharmaceutical interest with supercritical CO2

Burgos-Solorzano, Gabriela I.; Brennecke, Joan F.; Stadtherr, Mark A.

doi:10.1016/j.fluid.2004.01.036

Cited by 62 publications

(37 citation statements)

References 41 publications

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“…Performing a quick search through the literature, one can easily find data on the solubility (in scCO 2 ) of several drugs and other biomolecules of pharmaceutical interest, determined using different experimental methods. [2][3][4][5][10][11][12][35][36][37][38][39][40][41][42] Modeling and correlation of the solubility of solids in scCO 2 were also extensively investigated. [43][44][45][46][47][48][49][50][51] Solid solubilities in SCFs (and drug solubilities in particular) are not easy to predict because there is a lack of accurate models to simulate and predict equilibrium solubilities of these compounds in SCFs and there is not much information regarding most physical properties necessary for those available models.…”

Section: Introductionmentioning

confidence: 99%

Experimental Determination and Correlation of Artemisinin's Solubility in Supercritical Carbon Dioxide

et al. 2006

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The measurement and correlation of the experimental solubility of the antimalarial artemisinin (Artemisia annua L.) in supercritical carbon dioxide is reported. Results were obtained using a static analytical method at 308.2, 318.2, and 328.2 K, and in a pressure range from 10.0 up to 25.0 MPa. Solubility experimental data were correlated with three density-based models (Chrastil, Bartle, and Méndez-Santiago-Teja models) and with two cubic equation of state (EOS) models, namely, the Peng-Robinson EOS and the Soave-Redlich-Kwong EOS, together with the conventional van der Waals mixing and combining rules. Good correlation results were obtained between the calculated and the experimental solubility to all fitted models. Results clearly show the feasibility of processing this antimalarial drug using supercritical fluid technologies and processes.

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Section: Introductionmentioning

confidence: 99%

Experimental Determination and Correlation of Artemisinin's Solubility in Supercritical Carbon Dioxide

et al. 2006

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“…Cheng et al [137] also used a dual recirculation system to study the solubility of methyl oleate in carbon dioxide. Some others [138,139] have also published recent results using a recirculation method.…”

Section: Experimental Determination Of Solubilitiesmentioning

confidence: 99%

Solubilities in supercritical fluids

Knox

2005

Pure and Applied Chemistry

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Solubilities in supercritical fluids are of great importance in a wide variety of applications. These applications include: production of controlled drug delivery systems, powder processing, pollution prevention and remediation, methods for spraying paints and coatings, precipitation/crystallization processes, bioseparations, and food processing. Examples of some of these applications will be given.Supercritical fluid processes make use of the significant variation of solubility with pressure when the solvent is a supercritical fluid. This permits the accomplishment of many processes that would be otherwise very difficult to achieve. To fully understand the benefits of such processes, one must understand the phase behavior of such systems. The types of phase behavior that can be observed will be discussed, along with the ways that this behavior can be used to modify solubilities in such fluids.There have been many methods proposed for the experimental determination of solubilities in supercritical fluids. These will be reviewed in general, and recommendations for preferred methods given.Solubilities in supercritical fluids can be correlated and predicted by making use of thermodynamic calculations involving equations of state, as well as by other methods. The various methods will be reviewed, and recommendations given for various applications.

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“…Several works about the use of supercritical CO 2 for decaffeination of different vegetal matrix, such as coffee beans [7], cocoa butter [8], guarana seeds [9] and mate tea leaves [10], have been reported. In fact, the extraction of caffeine with supercritical CO 2 is one of the most well-known commercial examples of SFE processes [11]. Many patents have been published about decaffeination of tea and coffee where extraction of caffeine is carried out by means of different layouts [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of cosolvents (ethyl lactate, ethyl acetate and ethanol) on the supercritical CO 2 extraction of caffeine from green tea

Villanueva-Bermejo

Ibáñez

Reglero

et al. 2016

The Journal of Supercritical Fluids

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Solubility measurements and modeling of molecules of biological and pharmaceutical interest with supercritical CO2

Cited by 62 publications

References 41 publications

Experimental Determination and Correlation of Artemisinin's Solubility in Supercritical Carbon Dioxide

Experimental Determination and Correlation of Artemisinin's Solubility in Supercritical Carbon Dioxide

Solubilities in supercritical fluids

Effect of cosolvents (ethyl lactate, ethyl acetate and ethanol) on the supercritical CO 2 extraction of caffeine from green tea

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