Solubility enhancement of morin and epicatechin through encapsulation in an albumin based nanoparticulate system and their anticancer activity against the MDA-MB-468 breast cancer cell line

Abstract

Mor-HSA-NPs and EC-HSA-NPs are effective on MDA-MB-468 breast cancer cell lines.

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

“…The method was optimized to synthesize the nanoscale-level particles by changing their organic phase (i.e., acetone) and using different concentrations of pluronic F-68 (i.e., 1% final concentration, w/v). The method for the formulation of nanoparticles is dependent on several criteria, including the polymer, surfactant and drug concentration, the molecular weight of the polymer, aqueous and organic phase, stirring speed and time, temperature, etc., that control the size of the synthesized nanoparticles [44]. The synthesized nanoparticles were finally characterized by various techniques, such as DLS, PDI, Zeta potential, FTIR, XRD, FESEM, and TEM, and we further analyzed their efficacy in U87-MG cells.…”

“…The noticeable increase in size of the PCL-F68-D-NPs as compared to blank PCL-F68-NPs was due to the loading of Diosgenin. The nanoparticle size plays an important role in the delivery of therapeutic drugs or components [44]. The cellular uptake of nanoparticles is also dependent on the nanoparticle size [45,46].…”

“…The cellular uptake of nanoparticles is also dependent on the nanoparticle size [45,46]. Nanoparticles that are smaller in size, i.e., less than 300 nm, can be easily transported throughout human body [44]. Moreover, the Zeta potential of the Diosgenin-loaded nanoparticles (PCL-F68-D-NPs) was found to be −22.3 mV and −11.5 mV (Table 1).…”

Exploring the Inhibitory and Antioxidant Effects of Fullerene and Fullerenol on Ribonuclease A

“…29 , 30 This laboratory has also reported methods to prepare protein-based nanoparticles as well as poly(lactic- co -glycolic acid)-loaded nanoparticles to improve the solubility of bioactive compounds. 31 , 32 In this article, the focus is on the development of water-soluble fullerene derivatives to investigate their inhibitory and antioxidant abilities. Hydroxylated fullerenes, generally known as fullerenols (FulOH), are commonly used water-soluble fullerene derivatives.…”

Determination of solubility, stability and degradation kinetics of morin hydrate in physiological solutions

“…9 MH has been reported to possess several pharmacological activities, such as anti-inammatory, anticancer, antioxidant, antiarthritic, antifertility, antiplasmodic and antitumor. [9][10][11][12] Haddad et al extracted MH (purity > 90%, HPLC) from psidium guajava leaves using hydroalcoholic solution (70%). 13 Similar to other bioavonoids, MH exhibits poor aqueous solubility (28.7 mg mL À1 in water), which leads to low oral bioavailability.…”