Solubility and binary diffusion coefficient of argon in polyethylene glycols of different molecular weights

Trupej, Nina; Chen, Lin; Škerget, Mojca; Knez, Željko

doi:10.1016/j.supflu.2015.04.022

Cited by 14 publications

(4 citation statements)

References 37 publications

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“…This effect improves the yield of reaction due to a better interaction between the polymer and organic compound. 38,39 On this basis, temperature has a global negative effect and pressure has a positive effect in the experimental range analyzed according to the Pareto chart. Therefore, an increase in pressure and a decrease in temperature, at a constant C/A molar ratio, acted increasing the yield of reaction.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and Operating Optimization of the PEG Conjugate via CuAAC in scCO₂

et al. 2021

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A new sustainable green protocol for obtaining polyethylene glycol (PEG) conjugates, with a prototype molecule, which in this work was coumarin, by means of click chemistry is presented. The organic solvents commonly used for this type of reaction were replaced by supercritical carbon dioxide (scCO2). The synthesis and characterization of PEG-coumarin were successfully reported using FTIR, 1H NMR, and MALDI TOF. Subsequently, a preliminary study was carried out using the response surface methodology to examine the variables that most affect the use of scCO2 as a reaction medium. The main effects caused by these variables, individually and their binary interaction, have been estimated. The response surface methodology has been used in this work to screen variables using a factorial design 23. The p-values of temperature and pressure were 0.006 and 0.0117, being therefore the most significant variables of the response surface methodology study. Subsequently, a more intensive study has been carried out on the variables that have shown the greatest significant effect on reaction performance where an 82.32% synthesis success was achieved, which broadens the scope of the use of scCO2 as a reaction medium. The conjugated coumarin with mPEG-alkyne and coumarin were evaluated for their in vitro antioxidant activities by the DPPH radical scavenging assay and were found to exhibit substantial activities. The click product showed comparable or even better efficacy than the initial coumarin.

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Section: Resultsmentioning

confidence: 99%

“…A pressure increase or a temperature decrease favors the density upgrade. This effect improves the yield of reaction due to a better interaction between the polymer and organic compound. , …”

Section: Resultsmentioning

confidence: 99%

Synthesis and Operating Optimization of the PEG Conjugate via CuAAC in scCO₂

et al. 2021

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“…To measure the solubility of a solute in a solvent or solvent mixture, isothermal ,− and polythermal ,,,− methods are commonly employed. The main difference is that the isothermal method determines the unknown concentration of a solute in a solvent at known constant temperatures, while the polythermal method uses the known concentration to determine the temperature at which solubility is achieved by applying a constant heating rate. ,,,, …”

Section: Methodsmentioning

confidence: 99%

“…The main difference is that the isothermal method determines the unknown concentration of a solute in a solvent at known constant temperatures, while the polythermal method uses the known concentration to determine the temperature at which solubility is achieved by applying a constant heating rate. 26,28,30,39,42 In this study, the polythermal method was used, employing the automated multiple reactor system Crystal16 from Technobis Crystallization Systems as described elsewhere. 26,28,29,39 Briefly, suspensions composed of MOD and a neat solvent or a solvent mixture were prepared in 2 mL sealed glass vials (Fisher Scientific) at predetermined concentrations.…”

Section: ■ Introductionmentioning

confidence: 99%

Solubility Measurements and Correlation of Modafinil in Neat Solvents and Binary Solvent Mixtures

Mbodji,

Agrawal,

Mulero Cruz

et al. 2024

J. Chem. Eng. Data

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The solubility of modafinil (MOD) form I, an antinarcoleptic drug, was measured at temperatures ranging from 278.15 to 333.15 K in ten neat solvents (acetone, acetonitrile, dimethylformamide, ethanol, ethyl acetate, methanol, methylethylketone, 1-propanol, 2-propanol, and water) and two binary solvent mixtures (acetone + water and methanol + water). The results employing the polythermal method demonstrate that the solubility increases with increasing temperature in the neat solvents and at constant composition in the binary solvent mixtures. Moreover, the MOD solubility decreases with an increasing mass fraction of water (antisolvent) in the binary solvent mixture methanol + water. In the binary solvent mixture acetone + water, the solubility exceeds its solubility in neat acetone and water, reaching a maximum at a water mass fraction of ∼20 wt %. Based on the calculated average relative deviation (ARD %), the experimental solubility data agree with the correlated data using the modified Apelblat and λh equations. Additionally, powder X-ray diffraction confirms that the recrystallized solid in the neat and binary solvent mixtures was the commercial MOD form I, except for 2-propanol. Thus, the presented solubility data provide a pathway to engineer crystallization processes for MOD toward integrated manufacturing from flow synthesis to crystallization.

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