Solitary Schwannoma of the Cecum: Case Report and Review of the Literature

Neto, José Wilson Benevides de Mesquita; Leal, Renato Mazon Lima Verde; Brito, Eurivaldo Valente de; Cordeiro, Diego Fonseca; Costa, Marcelo Leite Vieira

doi:10.1159/000346785

Cited by 9 publications

(8 citation statements)

References 10 publications

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“…For differential diagnosis of schwannoma, abdominal CT scan can help differentiate between schwannoma and other mesenchymal tumors. Schwannomas appear as well-defined homogenous mural masses with low enhancement [ 1 , 5 , 7 , 10 , 11 , 14 , 35 , 36 , 40 , 51 , 70 ] in comparison with the heterogenous aspect of GIST and the ill-defined aspect of adenocarcinomas [ 72 ]. Less than half of the published case reports had a CT scan done, approximately half of these had endoluminal resection and did not require abdominal imaging.…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the colon and rectum: a systematic literature review

et al. 2018

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BackgroundSchwannomas of the colon and rectum are rare among gastrointestinal schwannomas. They are usually discovered incidentally as a submucosal mass on routine colonoscopy and diagnosed on pathologic examination of the operative specimen. Little information exists on the diagnosis and management of this rare entity.The aim of this study is to report a case of cecal schwannoma and the results of a systematic review of colorectal schwannoma in the literature.Main bodyPubMed, Scopus, and Cochrane database searches were performed for case reports and case series of colonic and rectal schwannoma.Ninety-five patients with colonic or rectal schwannoma from 70 articles were included. Median age was 61.5 years (59% female). Presentation was asymptomatic (28%), rectorrhagia (23.2%), or abdominal pain (15.8%). Schwannoma occurred in the left and sigmoid colon in 36.8%, in the cecum and right colon in 30.5%, and in the rectum in 21.1%. Median tumor size was 3 cm and 56.2% of patients who underwent preoperative colonoscopy had a typical smooth submucosal mass. At pathology, 97.9, 13.7, and 5.3% of schwannomas stained positive for S100, vimentin, and GFAP, respectively. The median mitotic index was 1/50.ConclusionsColorectal schwannoma is a very rare subtype of gastrointestinal schwannoma which occurs in the elderly, almost equally in men and women. Schwannoma should be included in the differential diagnosis of a submucosal lesion along with gastrointestinal stromal tumor, neuro-endocrine tumors, and leiomyoma-leiomyosarcoma. Definitive diagnosis is based on immunohistochemistry of the operative specimen. Rarely malignant, surgery is the mainstay of treatment.

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Section: Discussionmentioning

confidence: 99%

Schwannoma of the colon and rectum: a systematic literature review

et al. 2018

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“…Schwannomas are extremely rare tumours of nerve sheaths, developing from Schwann cells. In the GI tract, they present as spindle cell tumours and account for approximately 2–6% of all mesenchymal tumours [1].…”

Section: Discussionmentioning

confidence: 99%

“…Schwannomas of the gastrointestinal tract are spindle cell tumours that originate from peripheral nerve lining Schwann cells. Outside the central nervous system it represents a rare entity, accounting for approximately 2–6% of all mesenchymal tumours [1]. As it normally arises from intracranial nerves and spinal nerves, neurosurgeons encounter the bulk of these cases, however surgeons, radiologists, gastroenterologists and histopathologists are occasionally consulted.…”

Section: Introductionmentioning

confidence: 99%

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Schwannoma in the ascending colon, a rare finding on surveillance colonoscopy

Baig

Patel

Kazem

et al. 2019

Journal of Surgical Case Reports

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Schwannomas are peripheral nerve sheath tumours that can present as a rare tumour of GI tract, and even more uncommonly within the colon. We present a case of colonic schwannoma in an asymptomatic patient identified on surveillance colonoscopy. The tumour is of mesenchymal origin and is often challenging to diagnose prior to surgical resection. Endoscopy usually fails to provide adequate sample and diagnosis is usually confirmed on immunohistochemistry.

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“…It has been reported that perilesional lymphadenopathy are more often observed in gastric schwannomas than in gastric GIST (7). Although it is not certain, these lymph nodes are presumed to be reactive hyperplasia due to the fact that There are fourteen case reports of colonic schwannomas written in English or Korean and these reports provide accessible information about imaging findings (6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). We reviewed these cases as well as ours ( Table 1).…”

Section: Isolated Colonic Schwannoma In the Ascendingmentioning

confidence: 99%