Solitary renal metastasis from squamous cell carcinoma of the lung

Abstract

Rationale: Non-small cell cancer with isolated unilateral renal metastasis is rare, and the role of radical nephrectomy has not been determined. In the present study, a case of a patient with solitary kidney metastasis from squamous cell lung cancer who underwent radical nephrectomy is reported. Patient concerns: A 74-year-old patient diagnosed with pulmonary squamous cell lung cancer who had undergone radical pulmonary lobectomy and mediastinal lymph node dissection revealed a solitary mass in the right kidney during the follow-up. Diagnoses: Unilateral isolated kidney metastasis originated from squamous cell lung cancer. Interventions: The patient underwent radical right nephrectomy and squamous cell cancer metastasis was confirmed by the postoperative pathology results. Outcome: Lung cancer relapse was diagnosed and the patient died of cancer progression 10 months after the right nephrectomy. Lessons: Solitary renal metastasis is rare and squamous cell lung cancer might be the primary disease. Abdominal computed tomography (CT) is important in detecting solitary kidney metastasis during the follow up of patients with squamous cell lung cancer. Due to the rareness of isolated renal metastasis, the role of radical nephrectomy needs to be further investigated.

Isolated Renal Metastasis from Primary Lung Squamous Cell Carcinoma with Synchronous Small Cell Lung Cancer

“…Patients with tumor spread to the kidneys are usually asymptomatic, being diagnosed incidentally on imaging. Rarely, they may present with gross hematuria, dull abdominal, or back pain or early satiety [3,10]. Diagnosis of renal metastasis is usually by imaging modalities.…”

“…Synchronous occurrence of primary lung cancers with different histology is uncommon, seen in up to only 0.5% of patients with lung cancer [1-2]. Non-small cell lung cancer (NSCLC) constitutes 80% of all lung cancers, and squamous cell carcinoma (SCC) accounts for 40% of these [3]. SCC remains the most common type of lung malignancy seen in any combination of synchronous lung tumors [1].…”

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

“…The aspartate aminotransferase procedure was evaluated using a bichromatic (340-700 nm) rate method, which is a modification of the technique established by the International Federation of Clinical Chemistry (IFCC) [38].…”

Lung cancer and kidney injury: an updated review

“…Verma et al reported 4 cases of solitary kidney metastasis in individuals with pulmonary malignancy that experienced stereotactic body radiation therapy (SBRT) and concluded that SBRT for mitigation of renal metastases from NSCLC is a safe and effective treatment (65). Nephrectomy may also be a beneficial choice in the treatment of solitary kidney metastasis in individuals with NSCLC (66). In this regard, Adamy et al examined the effect of nephrectomy in patients with solitary renal metastatic tumors and suggested that surgical resection may be an appropriate approach with a positive effect on the patients' survival rate (67).…”