Isolated Renal Metastasis from Primary Lung Squamous Cell Carcinoma with Synchronous Small Cell Lung Cancer

Numan, Laith; Asif, Samia; Abughanimeh, Omar

doi:10.7759/cureus.4891

Cited by 5 publications

(11 citation statements)

References 14 publications

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“…The lung represents the main primary site for renal metastasis in the majority of studies; the incidence of renal metastases from a lung primary in clinical series is estimated between 26% and 46.5% 4–6,27,28. All different histologic types of lung carcinoma can metastasize to the kidney 22,29–48. In a Japanese series, Ichimatsu et al49 reviewed 64 cases of metastatic renal tumors originating from a lung primary and documented that the histologic subtypes were 57.6% squamous cell carcinoma, 28.8% adenocarcinoma, and 5.1% small cell carcinoma.…”

Section: Primary Tumor Sitesmentioning

confidence: 99%

“…In cases associated with solitary lesions, the distinction from a renal cell carcinoma is critical 151. Renal metastases can be diagnosed by renal ultrasound, CT scan, and MRI 6,42. Features supporting a diagnosis of metastasis include the presence of multifocal, endophytic lesions that are isodense or of lower attenuation compared with renal parenchyma and enhance only slightly with intravenous contrast 42…”

Section: Radiologic Featuresmentioning

confidence: 99%

“…Compared with primary renal tumors, metastases to the kidney were more often solid (86% vs. 53%) and endophytic (76% vs. 33%) 153. Occasionally, positron emission tomography (PET)/CT scan performed for other reasons may identify renal metastasis 42. Fluorine-18 fluorodeoxyglucose ( 18 F-FDG) PET/CT is extensively used in oncology, but its utilization in evaluating primary or metastatic involvement of the kidney is limited because physiological excretion of 18 F-FDG through the urinary tract may interfere with tumor imaging 37.…”

Section: Radiologic Featuresmentioning

confidence: 99%

“…No randomized control trials are available to determine the superiority of one treatment modality over the other. Therefore, treatment needs to be individualized for each patient 42…”

Section: Treatmentmentioning

confidence: 99%

“…[4][5][6]27,28 All different histologic types of lung carcinoma can metastasize to the kidney. 22,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] In a Japanese series, Ichimatsu et al 49 reviewed 64 cases of metastatic renal tumors originating from a lung primary and documented that the histologic subtypes were 57.6% squamous cell carcinoma, 28.8% adenocarcinoma, and 5.1% small cell carcinoma. Wu et al 4 documented adenocarcinoma (55%), and Huang et al 5 noted squamous cell carcinoma (68%) as the most common histologic types to metastasize to the kidney in their series.…”

Section: Lungmentioning

confidence: 99%

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Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Saeed

Osunkoya²

2022

Advances in Anatomic Pathology

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Metastases to the kidney are rare and were historically described in autopsy series, and the incidence ranged between 2.36% and 12.6%. However, in the contemporary literature with the improvements in imaging modalities (computed tomography scan and magnetic resonance imaging) and other health care screening services, metastatic tumors to the kidney are being diagnosed more frequently in surgical specimens. The utility of needle core biopsies in the primary evaluation of renal masses has also increased the number of sampled metastases, and as a result, only limited histologic material is available for evaluation in some cases and may potentially lead to diagnostic pitfalls. In the last decade, a few large clinical series have been published. In these series, the majority of metastatic tumors to the kidney are carcinomas, with the lung being the most common primary site. A significant number of the various tumor types with metastasis to the kidney are also associated with widespread metastases to other organs, and the renal metastasis may present several years after diagnosis of the primary tumor. The majority of secondary tumors of the kidney are asymptomatic, incidentally discovered, and solitary. There should be a high index of suspicion of metastasis to the kidney in patients with an associated enlarging renal lesion with minimal to no enhancement on imaging and tumor progression of a known high-grade nonrenal malignancy. Secondary tumors of the kidney can be accurately diagnosed by correlating histopathologic features with clinical and radiographic findings and the judicious use of ancillary studies.

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Section: Primary Tumor Sitesmentioning

confidence: 99%

Section: Radiologic Featuresmentioning

confidence: 99%

Section: Radiologic Featuresmentioning

confidence: 99%

“…No randomized control trials are available to determine the superiority of one treatment modality over the other. Therefore, treatment needs to be individualized for each patient 42…”

Section: Treatmentmentioning

confidence: 99%

Section: Lungmentioning

confidence: 99%

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Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Saeed

Osunkoya²

2022

Advances in Anatomic Pathology

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FDG PET/CT in Solitary Isolated Renal Metastasis From Squamous Cell Lung Cancer

Zhang,

Dong,

Wang

2023

Clin Nucl Med

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We describe FDG PET/CT findings in a patient with a solitary isolated renal metastasis from squamous cell lung cancer. The renal metastasis appeared as a small focus of activity at the renal cortex on FDG PET/CT at initial staging of the lung tumor, misinterpreted as cortical tracer retention, and was significantly enlarged on the second FDG PET/CT performed 4 months after the first PET/CT. This case demonstrates the usefulness of FDG PET/CT in identifying unexpected extrathoracic metastasis from lung cancer. Focal FDG uptake in the renal cortical region in a cancer patient should be evaluated carefully to avoid misdiagnosis.

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Metastases to the kidney from primary lung cancer : clinicopathological analysis of six cases in a single center

et al. 2023

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Objectives Cancer metastasis to the kidney is a rare event. We retrospectively analyzed clinicopathologic characteristics in 6 cases of diagnosed renal metastases from primary lung cancer. We also provide clinical follow-up data and brief review of the literature. Methods Immunohistochemistry was used to evaluate the expression of TTF-1, NapsinA, CK7, CK(AE1/AE3), P63, P40, CgA, PAX-8, GATA3 and Ki-67 in primary tumor and metastases. Additionally, the clinical characteristics, imaging features, diagnosis, and treatment were analyzed. Results With the help of immunohistochemistry and combined clinical history, we found four cases were lung adenocarcinomas, one case was lung squamous cell carcinoma, and the other case was lung small cell carcinoma metastases to the kidney.The patients were all male by gender and had a mean age of 62 years, and metastasis to the left kidney were more universal. Most of the tumors histological grade originating from the lung were poorly-moderately differentiated, and the time to metastasis to the kidney was relatively short for squamous lung cancer and small cell lung cancer, while the time to metastasis for lung adenocarcinoma was related to its degree of differentiation. Overall, we found the prognosis of lung cancer patients with renal metastases were poor especially with multi-site metastases. Conclusions Distinguishing primary and secondary tumors of the kidney is essential to guide treatment and prevent unnecessary surgery, so clinical information, radiology, histological correlation of the primary tumor, and immunohistochemical findings help the pathologist determine correct diagnosis.

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Isolated Renal Metastasis from Primary Lung Squamous Cell Carcinoma with Synchronous Small Cell Lung Cancer

Cited by 5 publications

References 14 publications

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

Secondary Tumors of the Kidney: A Comprehensive Clinicopathologic Analysis

FDG PET/CT in Solitary Isolated Renal Metastasis From Squamous Cell Lung Cancer

Metastases to the kidney from primary lung cancer : clinicopathological analysis of six cases in a single center

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