Solitary Renal Metastasis 23 Years After Extirpation of A Bronchial Adenoid Cystic Carcinoma

Ladefoged, C.; Bisgaard, Christer Z.; Petri, Jens

doi:10.3109/14017438409109900

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…2 Data from the English literature (Table 1) report 35 well-described cases of renal involvement from lung cancer. [1][2][3][4][5][6][7][8][9][10][11] The median age at presentation was 57 years, with a male sex predominance (male to female ratio, 9:1) and a latency of presentation from the diagnosis of the primary lung lesion of 30 months. In 5 cases, the renal involvement was present before the lung primaries and in 3 cases both were discovered at the same time.…”

Section: Discussionmentioning

confidence: 99%

Renal Metastasis From Pulmonary Adenocarcinoma

Scatena

Comin

Lapini³

et al. 2013

Applied Immunohistochemistry &Amp; Molecular Morphology

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We herein report an uncommon case of renal metastasis from the lung in a 72-year-old man who 2 years before underwent surgical treatment for a pulmonary adenocarcinoma. During follow-up, a computed tomography scan revealed the presence of a solid mass located in the right kidney. Histopathologic and immunohistochemical examination of the enucleated lesion demonstrated the renal localization of an adenocarcinoma of the lung. Clinically recognized renal metastatic lesions from pulmonary cancer are a rare finding with only 35 cases reported to date in the English literature, and renal localization of adenocarcinoma of the lung is extraordinarily uncommon. Together with suggestive clinical data and negativity for markers of adenocarcinomas of different origin, thyroid transcription factor-1, when positive, is considered to be the most reliable marker for the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Renal Metastasis From Pulmonary Adenocarcinoma

Scatena

Comin

Lapini³

et al. 2013

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…ACC of the trachea and bronchi arises from glands in the tracheobronchial mucosa. ACC is characterized by slow growth, and distant metastasis has been reported as late as 25 years after diagnosis [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma

Song

Kim

et al. 2017

Radiat Oncol

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BackgroundTo evaluate the role of radiotherapy (RT) as an adjuvant or definitive treatment in primary tracheal adenoid cystic carcinoma (ACC) for local tumor control and survival.MethodsA retrospective chart review was performed in 22 patients treated with adjuvant or definitive RT for primary tracheal ACC at a single center between November 1994 and December 2008.ResultsThirteen and 9 patients received adjuvant and definitive RT, respectively. Microscopic residual disease after surgery was pathologically reported in 11 patients. The median RT dose was 59.4 Gy for adjuvant and 74.4 Gy for definitive RT. The overall response rate for definitive RT was 77.8%. Six patients in the definitive RT group exhibited local progression (LP), whereas 14 patients in both groups exhibited distant metastasis. The most common recurrence site in cases of treatment failure was the lung parenchyma. The median follow-up duration was 123 months, and the 10-year overall survival (OS) rate was 54.2%. Although LP was the most common cause of death (4 patients), two-thirds of the patients treated with definitive RT lived for >5 years. The 5-year and 10-year LP-free survival (LPFS) rates in the definitive RT group were 66.7 and 26.7%, respectively. Patients with higher RT dose by brachytherapy boost had good 5-year OS, 83.3%, and showed no local progression till 5-years. Most of the RT-induced side-effects were mild and tolerable, but 2 patients died of tracheal stenosis without any tumor recurrence.ConclusionsAdjuvant RT may be suitable for controlling microscopic residual disease, whereas definitive RT may yield appropriate long-term survival in >50% patients with unresectable tracheal ACC. Dose escalation should be considered to warrant long-term survival in definitive RT.

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“…Nevertheless, kidney metastasis of ACC is extremely rare. In 1984, Ladefoged et al 5 first described metastatic ACC of the kidney, 23 years after right pneumonectomy for ACC of lung 5 . To our knowledge, only 11 cases of ACC metastatic to the kidney have been described in detail in the English literature to date.…”

Section: Discussionmentioning

confidence: 99%

An unusual case report of pulmonary adenoid cystic carcinoma metastasis to the kidney. Case report and literature review

Junejo

Almusalam

Alothman

et al. 2019

Urology Case Reports

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Adenoid cystic carcinoma (ACC) is a malignant neoplasm, frequently affecting the salivary glands, and rarely occurring in other locations. ACC is characterized by slow growth, perineural invasion, local and late recurrence after original treatment. However, renal metastasis of ACC is very rare. To our best knowledge, only 11 cases of ACC metastasis to the kidney have been reported in the English literature to date. Herein, we presented a rare case of a 70-year-old man with renal metastasis from ACC of the right lung after 3 years of primary presentation. Our patient underwent right radical nephrectomy and histologically confirmed as Metastatic Adenoid Cystic Carcinoma.

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Solitary Renal Metastasis 23 Years After Extirpation of A Bronchial Adenoid Cystic Carcinoma

Cited by 14 publications

References 17 publications

Renal Metastasis From Pulmonary Adenocarcinoma

Renal Metastasis From Pulmonary Adenocarcinoma

A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma

An unusual case report of pulmonary adenoid cystic carcinoma metastasis to the kidney. Case report and literature review

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