Solitary recurrence of castration-resistant prostate cancer with low or undetectable levels of prostate specific antigen salvaged with local ablative radiation therapy: A case report

Wang, Chiachien Jake; Ying, James; Kapur, Payal; Wohlfeld, Bryan J; Roehrborn, Claus G.; Kim, Dong W. Nathan

doi:10.3892/ol.2015.3940

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Most commonly, patients with oligorecurrence or de novo oligometastatic disease have been identified using a specific cutoff for the number of distant sites involved. A list of previously published literature with associated oligometastatic definitions is displayed in Table , with similar definitions used by ongoing, prospective investigations listed in Table . Of 25 retrospective reviews that included >1 case, 10 (40%) used a definition of ≤5 metastases, 3 (12%) used a definition of ≤4 metastases, and 12 (48%) used a definition of ≤3 metastases to define patients with oligometastases in the recurrent or de novo setting.…”

Section: Defining Oligometastases: Clinical and Biologic Factorsmentioning

confidence: 99%

Oligometastatic prostate cancer: Reality or figment of imagination?

Foster

Weichselbaum

Pitroda

2018

Cancer

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The term “oligometastatic prostate cancer” refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Nevertheless, emerging prospective data have corroborated the “better‐than‐expected,” retrospectively observed outcomes, particularly in the setting of oligorecurrent prostate cancer. Improved functional imaging with prostate‐specific membrane antigen‐targeted strategies may enhance the identification of patients with oligometastatic prostate cancer in the short term. In the long term, refinement of the oligometastatic case definition likely will require biologic risk‐stratification schemes. To determine optimal treatment strategies and identify patients most likely to benefit from metastasis‐directed therapy, future efforts should focus on conducting high‐quality, prospective trials with much‐needed molecular correlative studies.

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Section: Defining Oligometastases: Clinical and Biologic Factorsmentioning

confidence: 99%

Oligometastatic prostate cancer: Reality or figment of imagination?

Foster

Weichselbaum

Pitroda

2018

Cancer

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“…The treatment of this disease depends on the type of cancer as well as on the subtype or stage of the patient and is currently based on hormones, chemotherapy, radiotherapy, pharmaceuticals, and nanotherapy. However, these treatments are aggressive, highly expensive, and unatainable for many people [12]. Unfortunately, some cancer tumors are extremely resistant to current therapeutic agents; therefore, the development of new strategies in prevention, treatment, and control of cancer is urgently needed [13].…”

Section: Introductionmentioning

confidence: 99%

Anthocyanin Profile of Red Maize Native from Mixteco Race and Their Antiproliferative Activity on Cell Line DU145

Herrera-Sotero¹,

González-Cortés²,

Galindo³

et al. 2017

Flavonoids - From Biosynthesis to Human Health

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Mexico is regarded as the point of origin and biodiversity of maize, which takes the colors white, yellow, blue, or red. Red maize in particular owes its coloring to a type of polyphenolic compounds known as anthocyanins. The aim of this study was to determine the proile anthocyanin of red maize, as well as their antiproliferative activity on prostate cancer cell line DU145. Three samples of red maize were analyzed. Total polyphenols, monomeric anthocyanins, antioxidant activity by DDPH and FRAP were evaluated. The sample of red maize with the highest levels of total polyphenols and monomeric anthocyanins was selected, and its anthocyanin fraction was analyzed by HPLC-ESI-MS. Twenty compounds were detected in the anthocyanin proile, and from these, 12 anthocyanins derived of cyanidin were identiied. MTT assay was used to determine the antiproliferative activity of the anthocyanin fraction from red maize at diferent concentrations (7-1000 μg/mL), and a signiicant antiproliferative activity was observed at 1000 μg/mL.Microscopy analysis showed that the anthocyanin fraction of red maize induced apoptosis in cell lines DU145. This is the irst report showing that anthocyanin fraction of red maize possess antiproliferative activity in the DU145 cell line.

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