Anthocyanin Profile of Red Maize Native from Mixteco Race and Their Antiproliferative Activity on Cell Line DU145

Herrera-Sotero, Mónica; González-Cortés, Francisco; Galindo, Hugo García; Juárez-Aguilar, Enrique; Dorantes, Mauricio Rodríguez; JoséChávez-Servia,; Oliart-Ros, Rosa María; Guzmán-Gerónimo, Rosa Isela

doi:10.5772/67809

Cited by 3 publications

(2 citation statements)

References 18 publications

(17 reference statements)

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“…The in vitro cytotoxic activity of sclerin ( 1 ) and cyclosenegalin A ( 2 ) was assessed by XTT assay, using the prostate cancer cell line DU-145 [16,17]. As shown in Table 2, sclerin ( 1 ) and cyclosenegalin A ( 2 ) were able to inhibit cell proliferation of the human prostate cancer at μM concentration.…”

Section: Resultsmentioning

confidence: 99%

Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma

et al. 2019

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A new cytotoxic cyclononapeptide, sclerin, cyclo(–Dab1–Ser2–Tyr3–Gly4–Thr5–Val6–Ala7– Ile8–Pro9–) (1), was isolated from the methanol extract of the seeds of Annona scleroderma, together with the known metabolite, cyclosenegalin A, cyclo(–Pro1–Gly2–Leu3–Ser4–Ala5–Val6–Thr7–) (2). The planar structures for the two compounds were established by comprehensive analysis of NMR and ESI-HRMS data, and the absolute stereochemistry was stablished by Marfey’s method. Compound 1 showed moderate cytotoxic activity against the human prostate carcinoma cell line DU-145 at µM concentration.

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Section: Resultsmentioning

confidence: 99%

Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma

et al. 2019

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“…In a previous study, the chemical profile assessment of ACNs via HPLC-ESI-MS identified 20 compounds, characterizing cyanidin 3-p-hydroxy-benzoyl sophoroside-5-glucoside, C3G ( Figure 4 ), and cyanidin-3-O-(6′-acetyl-arabinoside) ( Figure 6 ) as major compounds. MTT assessments exerted significant antiproliferative activity and apoptosis effect in cell lines DU145 at 1000 μg/mL [ 65 ].…”

Section: Anti-prostate Cancer Properties Of Anthocyanidins/anthocyaninsmentioning

confidence: 99%

The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer

Mottaghipisheh

Doustimotlagh

Irajie

et al. 2022

Cells

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As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity properties of these advantageous phytochemicals have been reported; among them, their significant abilities in the suppression of tumor cells are of the promising therapeutic features, which have recently attracted great attention. The prostate malignancy, is considered the 2nd fatal and the most distributed cancer type in men worldwide. The present study was designated to gather the preclinical and clinical studies evaluating potencies of anthocyanidins/anthocyanins for the treatment and prevention of this cancer type for the first time. In general, findings confirm that the anthocyanins (especifically cyanidin-3-O-glucoside) indicated higher activity against prostatic neoplasms compared to their correlated anthocyanidins (e.g., delphinidin); in which potent anti-inflammatory, apoptosis, and anti-proliferative activities were analyzed. Complementary anti-prostate cancer assessment of diverse naturally occurred anthocyanidins/anthocyanins and their synthetically optimized derivatives through preclinical experiments and eventually confirmed by clinical trials can promisingly lead to discover natural-based chemotherapeutic drug options.

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Preparation and quality evaluation of flour and biscuits made from red corn powder using as supplement with different ratios of red corn flour

Toàn¹,

Tran²

2022

int.jour.sci.res.mana.

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The consumption of cereal foods such as biscuits has become very popular globally. Also, in recent years, nutritional potential is prioritized in every foodstuff. Different types of maize such as yellow, sweet corn are one of well-known healthy ingredients for developing new biscuit products, except red corn. This has spurred pragmatic research on developing biscuits prepared by blending wheat flour with red corn powder in ratios of 5%, 10%, and 15%. This study was, conducted to investigate functional properties of composite flours. The effects of three levels of red corn powder in the physical dimensions, nutritional constituents, consumers’ acceptability and compared to the quality of 100% wheat biscuits. In essence, partial substitution of wheat flour with red corn powder witnessed an increase in protein and fiber. Besides, a significant increase was noticed in total phenolic content and the antioxidant (p<0.05) compared to control samples. 5% and 10% red corn flour-biscuits also predominated the most in the sensorial acceptability. The collected results of this study witnessed an improvement in terms of nutritional value, health benefits and a high potential of being accepted by consumers of developed biscuits. Key words: Red corn powder, Biscuits, Nutritional value, Antioxidant, Total phenolic content, Fiber content, Red corn supplemented biscuits.

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Anthocyanin Profile of Red Maize Native from Mixteco Race and Their Antiproliferative Activity on Cell Line DU145

Cited by 3 publications

References 18 publications

Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma

Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma

The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer

Preparation and quality evaluation of flour and biscuits made from red corn powder using as supplement with different ratios of red corn flour

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