Solitary Peutz-Jeghers Type Colorectal Polyp with Hamartoma-adenoma-carcinoma Sequence in a Non-Peutz-Jeghers Syndrome Patient

Arima, Shuei; Kunimura, Toshiaki; Matsuo, Kai; Hobo, Takahiro; Nogaki, Koji; Kato, Kaoru; Hosaka, Hisashi; Saito, Koji; Sugiyama, Tomoko; Morohoshi, Toshio

doi:10.15369/sujms.22.69

Cited by 4 publications

(3 citation statements)

References 12 publications

(5 reference statements)

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“…Although it is beyond the scope of this case report to verify each possibility, Arima et al. reported a case of a colorectal Peutz‐Jeghers type polyp with hamartoma‐adenoma‐carcinoma sequence in a non‐Peutz‐Jeghers syndrome patient 10 . A disease trajectory along the hamartoma‐adenoma‐carcinoma sequence has thus been suggested to explain the cancerous transformation in hamartomatous polyps.…”

Section: Discussionmentioning

confidence: 93%

“…Although it is beyond the scope of this case report to verify each possibility, Arima et al reported a case of a colorectal Peutz-Jeghers type polyp with hamartoma-adenoma-carcinoma sequence in a non-Peutz-Jeghers syndrome patient. 10 A disease trajectory along the hamartoma-adenoma-carcinoma sequence has thus been suggested to explain the cancerous transformation in hamartomatous polyps. In addition, the rate of CCS-related cancer was reported to be lower in patients with sustained endoscopic remission, compared to those with relapses or nonresponders.…”

Section: Discussionmentioning

confidence: 99%

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Narrow‐band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite‐Canada syndrome

et al. 2023

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Cronkhite‐Canada syndrome (CCS) is a rare disease characterized by gastrointestinal polyposis, skin pigmentation, alopecia, and abnormal nailfolds. Although colorectal cancer has been reported in patients with CCS, reports are limited regarding the effectiveness of the usage of image‐enhanced endoscopy in CCS lesions. Here, we report a case of CCS in which narrow‐band imaging (NBI) magnifying endoscopy was applied to detect an adenomatous component in multiple hamartomatous polyps. A 79‐year‐old female complained of taste disorder, anorexia, and weight loss over several months. Endoscopic examination revealed multiple reddened polyps in the stomach and colon, leading to a diagnosis of CCS. Narrow‐band imaging magnification showed sparse and dilated round pits on the CCS polyps. Furthermore, 12 out of the numerous colorectal CCS polyps had a coexisting light reddish elevated component with a regular distribution of microvessels and a regular reticular pattern. This pattern satisfied the criteria for Type 2A of the Japan Narrow‐band‐imaging Expert Team classification, indicating adenoma. After resection, these twelve polyps were subject to pathological analysis, which confirmed they were all hamartomatous polyps with low‐grade adenoma on the superficial layer. Immunohistochemical analysis revealed a significant increase in the Ki‐67 index and p53 staining only in the adenomatous lesions. We conclude that narrow‐band imaging magnifying endoscopy would be useful in differentiating adenoma from CCS‐related polyps, which thereby facilitates early detection and treatment of precancerous lesions.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Narrow‐band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite‐Canada syndrome

et al. 2023

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“…This supported the hypothesis that both solitary Peutz–Jeghers-type polyp and PJS are associated with the risk of cancer. Arima [ 23 ] reported a case of solitary Peutz–Jeghers-type polyp with the hamartoma–adenoma–carcinoma sequence. Limaiem et al [ 24 ] reported a case of solitary rectal Peutz–Jeghers-type polyp with adenomatous transformation.…”

Section: Discussionmentioning

confidence: 99%

A giant and extensive solitary Peutz–Jeghers-type polyp in the antrum of stomach

Zou

Fengfan²,

Zhao³

et al. 2017

Medicine

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Rationale:A solitary Peutz–Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz–Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.Patient concerns:A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. A gastroscopy showed a giant and extensive bulging lesion on the greater curvature and posterior and anterior walls of the gastric antrum, involving three-quarters of the gastric wall. Endoscopic ultrasonography showed a muscularis mucosa lesion.Diagnoses:A solitary Peutz–Jeghers-type polyp in the antrum of stomach.Interventions:The patient underwent an endoscopic submucosal dissection (ESD).Outcomes:The patient recovered quickly, without any complications.Lessons:This is the second largest gastric solitary Peutz–Jeghers-polyp reported until now, and the largest gastric solitary Peutz–Jeghers type-polyp treated by endoscope.

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Gentle Giant? Giant Gastric Solitary Peutz-Jeghers Polyp

Mongardini,

Nazzaro,

Fuschillo

et al. 2024

Dig Dis Sci

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Solitary Peutz-Jeghers Type Colorectal Polyp with Hamartoma-adenoma-carcinoma Sequence in a Non-Peutz-Jeghers Syndrome Patient

Cited by 4 publications

References 12 publications

Narrow‐band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite‐Canada syndrome

Narrow‐band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite‐Canada syndrome

A giant and extensive solitary Peutz–Jeghers-type polyp in the antrum of stomach

Gentle Giant? Giant Gastric Solitary Peutz-Jeghers Polyp

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