A giant and extensive solitary Peutz–Jeghers-type polyp in the antrum of stomach

Abstract

Rationale:A solitary Peutz–Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz–Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.Patient concerns:A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. A gastroscopy showed a giant and extensive bulging lesion on the greater curvature and posterior and anterior walls of the gastric antrum, involving three-quarters of the gastric wall. Endoscopic ultrasonography showed a muscularis mucosa lesion.Diagnoses:A solitary Peutz–Jeghers-type polyp in the antrum of stomach.Interventions:The patient underwent an endoscopic submucosal dissection (ESD).Outcomes:The patient recovered quickly, without any complications.Lessons:This is the second largest gastric solitary Peutz–Jeghers-polyp reported until now, and the largest gastric solitary Peutz–Jeghers type-polyp treated by endoscope.

A Case Report and Literature Review of a Rare Jejunal Solitary Peutz–Jeghers-Type Polyp Resected Endoscopically in an Elderly Patient Presenting with Subacute Gastrointestinal Bleeding

“…Individuals with Peutz–Jeghers syndrome are at increased risk of different types of malignancies, such as gynecological, GI, and pancreaticobiliary carcinomas [ 13 ]. On the other hand, the malignant potential of SPJP is controversial [ 14 ]. Initial studies in the early 2000s suggested a benign course [ 15 ]; however, subsequent studies have contradicted the initial thoughts.…”

“…Initial studies in the early 2000s suggested a benign course [ 15 ]; however, subsequent studies have contradicted the initial thoughts. There have been cases that reported an association between SPJS with different malignancies [ 14 ]. Another study looked at the genetic and epigenetic analysis of colonic SPJP and detected epigenetic mutations similar to the mutations seen in colorectal cancer [ 3 ].…”

Giant gastric polyp in peutz–Jeghers syndrome: Report of a case

“…that measured 110 mm × 80 mm × 4 mm in 2017. [ 6 ] Both the cases were adults, and they were reported in a 53-year-old male and a 43-year-old female, respectively. It is worth noting that a giant gastric polyp in PJS is extremely rare, and to our belief, this is the first case being reported from the pediatric age group.…”

“…were the first to report endoscopic submucosal resection for a giant solitary gastric polyp in PJS. [ 6 ]…”

Rare solitary giant hamartomatous polyp of the stomach removed by endoscopic submucosal dissection

“…Given the reported risk for neoplastic transformation, SGHPs are generally referred for resection. 4 , 5 ESD may be an alternative to surgery for selected cases. We recommend close postoperative monitoring as delayed perforation can occur after large resections, and prompt recognition and intervention can prevent peritonitis and need for surgery.…”