Solitary Fibrous Tumour of the Prostate Identified on Needle Biopsy

Galosi, Andrea Benedetto; Mazzucchelli, Roberta; Scarpelli, Marina; López-Beltrán, Antonio; Liu, Cheng; Muzzonigro, Giovanni; Montironi, Rodolfo

doi:10.1016/j.eururo.2009.02.019

Cited by 21 publications

(32 citation statements)

References 10 publications

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“…A single institution study of prostate solitary fibrous tumours identified malignant features but found no recurrence over a follow-up of 1–10 years 23. Our cases of prostatic solitary fibrous tumours in this study are similar to published cases/series: large tumours (6–7 cm), older patients and few malignant histological features 1 23–25…”

Section: Discussionsupporting

confidence: 85%

“…Solitary fibrous tumours are rare spindle cell neoplasms—generally arising—from the pleura, but may also involve extrapleural sites including the genitourinary tract 1. The clinical course of this tumour is largely indolent; however, aggressive malignant solitary fibrous tumours occur in 15–20% of cases, presenting in an insidious manner with aggressive behaviour 2.…”

Section: Introductionmentioning

confidence: 99%

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Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with theNAB2-STAT6fusion gene

et al. 2016

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Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2. Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11-64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a breakapart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours. Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a breakapart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with theNAB2-STAT6fusion gene

et al. 2016

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“…Based on the results of histopathological and immunohistochemical analyses, including the arrangement of the tumor cells in an irregular pattern, the identification of short-spindled cells possessing meagre amounts of eosinophilic cytoplasm, the presence of bland nuclei with uniformly distributed chromatin and inconspicuous nucleoli, immunoreactivity to CD34 and bcl-2 but negative immunoreactivity to CD117, anaplastic lymphoma kinase, smooth muscle actin and progesterone receptors, a diagnosis of SFT was reached. Following treatment with nerve-sparing retropubic radical prostatectomy, the mass was well delineated with no apparent invasion of the bladder neck or pelvic wall identified (2). Finally, two males aged 66 and 69 years-old, presenting with urinary tract symptoms, were diagnosed with SFT, by transrectal needle biopsy and TUR of the prostate, in 2011.…”

Section: Introductionmentioning

confidence: 97%

“…However, over the past 10 years, increasing numbers of extrapleural SFTs have been reported, including those of the prostate. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide (2,3). According to these reports, 13 cases of prostate SFT were identified by prostate needle biopsy or transurethral resection (TUR) of the prostate.…”

Section: Introductionmentioning

confidence: 99%

Solitary fibrous tumors of the prostate: A case report

et al. 2015

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Abstract. Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide. In the present study, a prostate SFT case, which was initially misdiagnosed as benign prostatic hyperplasia, is presented. The patient was subjected to three surgeries (cystoscopy and per urethra lithocystotomy, transurethral resection of the prostate and nerve-sparing retropubic radical prostatectomy) prior to SFT diagnosis. It was demonstrated that histopathological and immunohistochemical factors (positive staining for CD34 and B cell lyphoma-2 expression) were of significant diagnostic value. Thus, nerve-sparing retropubic radical prostatectomy for total resection may be the best therapeutic strategy to treat prostate SFT, allowing the preservation of sexual function and reducing the risk of locoregional recurrence.

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“…Andrea et al have recommended the following treatment plan for prostate SFT: (1) A repeat biopsy should be performed to achieve a more accurate diagnosis, (2) short-term follow-up is advisable for elderly patients with a small lesion, and (3) nerve-sparing radical prostatectomy should be performed in young patients with a large lesion and serious urinary tract symptoms; furthermore, cystoprostatectomy should be performed if invasion to the bladder is identified [6]. …”

Section: Discussionmentioning

confidence: 99%