Solitary fibrous tumour (myofibroblastoma) of the breast

Abstract

Three new cases of the spindle cell tumour of the breast, usually termed myofibroblastoma, are reported. The histology and the immunological profile (expression of vimentin, CD34 antigen and of muscular markers) appear similar to those of solitary fibrous tumours recently described in various sites. It is proposed to include these mammary lesions into the group of solitary fibrous tumours and to regard breast as an additional site of origin.

Solitary Fibrous Tumor of the Soft Tissue:An Immunohistochemical and Ultrastructural Study

“…Immunohistochemical examination should be of aid by demonstrating positivity with smooth muscle markers in vascular leiomyo- 16 and muscular differentiation with actin and/or desmin immunophenotypes, along with CD34 positivity. 13 The frequent storiform pattern coupled with the occasional presence of bizarre giant cells seen in solitary fibrous tumors may raise the question of benign or malignant fibrous histiocytoma in the differential diagnosis. However, the present tumors are histologically distinguishable from malignant fibrous histiocytoma on the basis of a low mitotic rate, and the absence of nuclear atypia and areas of necrosis.…”

“…' This tumor that usually arises in the pleura 2 " 9 has subsequently been recognized in a variety of sites, including other serosal surfaces: the peritoneum and pericardium, 10 " 12 and nonserosal sites: the breast, 13 thyroid,' 4 lung, 12 ' 5 mediastinum, 1216 orbit, 1718 parotid gland, 19 upper respiratory tract, 20 and nasal cavity and paranasal sinuses. 21 Recently, several cases of solitary fibrous tumor have been reported in somatic soft tissues unrelated to serosal surfaces.…”

Fine Needle Aspiration Cytology Presentation of a Cellular Variant of Breast Myofibroblastoma

“…6 Myofibroblastomas have to be distinguished from several benign and malignant spindle cell breast tumors. [1][2][3]5,6 Nodular and proliferative fasciitis, fibromatosis, leiomyoma, spindle cell lipoma, myoepithelioma and peripheral nerve sheath tumors (PNSTs) are examples of benign tumors that have been considered in the differential diagnosis. Although atypias are not common in myofibroblastomas, malignant tumors, such as sarcomas and sarcomatoid carcinomas, should also be considered when one evaluates this lesion.…”

“…6 Moreover, some authors showed expression of CD 34 by some of these tumors and emphasized their similarities with the solitary fibrous tumors of soft tissues and serosal cavities. 3 We had the opportunity to study a case of a cellular variant of myofibroblastoma of the breast in a male with fine needle aspiration (FNA). Here we report the cytologic findings, as well as the histologic and immunohistochemical characterization of this form of myofibroblastoma, adding one more challenging diagnostic condition for the classification of benign spindle cell proliferation of the breast on FNA.…”

Mammary Myofibroblastoma With Leiomyomatous Differentiation

“…Myofibroblastoma of the breast was first formally characterized in 1987 as a benign spindle cell neoplasm with male predominance 2 ; since then, few reports have described this uncommon neoplasm. [5][6][7][8][9] In 1994, Damiani et al 5 reported three lesions with morphologic and immunohistochemical features (vimentin and CD34 positive) that resembled those of solitary fibrous tumor, and therefore proposed that mammary myofibroblastoma be placed in this group and termed "solitary fibrous tumor of the breast." Solitary fibrous tumor has become an increasingly popular designation, and the lesion now is recognized to occur in almost any site in the body.…”