Fine Needle Aspiration Cytology Presentation of a Cellular Variant of Breast Myofibroblastoma

Schmitt, Fernando; Mera, Alberto de La Cruz

doi:10.1159/000331833

Cited by 28 publications

(40 citation statements)

References 4 publications

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“…As expected, the collagenized variant showed smears with scarce cellularity and fibrous stroma and may resemble a solitary fibrous tumor. One of our cases corresponds to the cellular variant and showed findings similar to those reported previously [9,13]. This variant can be particularly problematic because of the prominent cellularity seen on cytology.…”

Section: Discussionsupporting

confidence: 87%

“…Due to the rarity of MFB the role of cytology in its preoperative diagnosis is still not well established. Reflecting its rarity, few cytologic descriptions are available, and most of them consist of isolated cases [4,5,6,7,8,9,10,11,12,13,14,15]. In this report we describe 6 cases of mammary MFB in which fine-needle aspiration cytology (FNAC) was performed preoperatively.…”

Section: Introductionmentioning

confidence: 99%

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Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Álvarez-Rodríguez

Gimeno-Aranguez²,

López-Varela³

et al. 2012

Acta Cytologica

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Objective: To evaluate cytologic features of mammary myofibroblastoma in order to establish the possibility of precise preoperative recognition. Study Design: This was a multi-institutional study of 6 patients with myofibroblastoma (5 men and 1 woman) in which preoperatively fine-needle aspiration cytology was performed. Four cases showed classical histologic features, 1 corresponded to the cellular variant and the remaining 1 to the fibrous form. Results: Except for 1 case, smears were cellular and distributed as irregular aggregates and single cells. Most groups showed a small amount of metachromatic stroma and capillaries. Cells retained cytoplasm and showed a spindle-to-plump oval morphology with moderate pleomorphism. Nuclear pleomorphism was present and was relevant in 1 case. Intranuclear pseudoinclusions and mast cells were present in 3 cases. No epithelial clusters were seen. Due to hypercellularity and pleomorphism 1 case was considered as suspicious for malignancy. The remaining 5 were diagnosed as low-grade mesenchymal lesions, and myofibroblastoma was suggested in 3. Conclusion: Cytologic features of myofibroblastoma reflect what is seen on histology. When such findings are correlated with image studies, preoperative recognition can be possible. This is especially true for male patients in whom the tumor is relatively frequent.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Álvarez-Rodríguez

Gimeno-Aranguez²,

López-Varela³

et al. 2012

Acta Cytologica

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“…Table I summarizes their clinicopathologic findings. [1][2][3][4][5] There were seven men and one woman, ranging in age from 40 to 69 years (mean, 58.3). Size ranged from 1.5 to 3.8 cm (mean, 2.3) in greatest dimension.…”

Section: Discussionmentioning

confidence: 99%

“…Size ranged from 1.5 to 3.8 cm (mean, 2.3) in greatest dimension. [1][2][3][4][5] The cytologic diagnosis is detailed in only four of the cases, and in none of them was a diagnosis of malignancy rendered. [2][3][4] Grooved nuclei (best seen with Papanicolaou stain) were noted in only 50% of cases (not including ours).…”

Section: Discussionmentioning

confidence: 99%

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Fine Needle Aspiration of Breast Myofibroblastoma

López‐Ríos

Burgos²,

Madero³

et al. 2001

Acta Cytologica

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Cytomorphologic features that distinguish schwannoma from other low‐grade spindle cell lesions

Chebib

Hornicek

Nielsen

2015

Cancer Cytopathology

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BACKGROUND: Fine-needle aspiration biopsy of spindled mesenchymal lesions, including schwannomas, are challenging because of overlapping cytomorphological features. The objective of the current study was to identify key diagnostic cytological criteria for the diagnosis of schwannoma and to distinguish it from its common mimics. METHODS: A total of 58 schwannomas were evaluated and compared with 98 benign and low-grade spindle cell lesions, including 17 gastrointestinal stromal tumors and 20 fibromatosis cases. Biopsy confirmation was available for all cases. The authors semiquantitatively evaluated cellularity, quality of stroma (fibrous and fibrillar), the presence of single cells with bipolar cytoplasmic processes, and marked nuclear pleomorphism (in the absence of other features of malignancy). Nuclear features evaluated included fishhook-type nuclei, intranuclear inclusions, chromatin pattern, and nucleoli. RESULTS: Schwannomas demonstrated cohesive tissue fragments with fibrillary and occasionally fibrous stroma. The presence of intranuclear inclusions and marked nuclear pleomorphism and the absence of single cells with bipolar cytoplasmic processes emerged as statistically significant differences between the schwannoma and the nonschwannoma groups. When 5 criteria were present (high numbers of clusters, few to no single cells, fibrillary stroma, nuclei with pointed tips, and anisonucleosis) the sensitivity, specificity, positive predictive value, and negative predictive value for the diagnosis of schwannoma were 22%, 97%, 81%, and 68%, respectively. CONCLUSIONS:Cohesive tissue fragments with fibrillary/fibrous stroma, intranuclear inclusions, marked nuclear pleomorphism, and the absence of spindled cells with bipolar cytoplasmic processes are strongly suggestive of schwannoma and assist in excluding potential mimics. Cancer (Cancer Cytopathol) 2015;123:171-9.

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Fine Needle Aspiration Cytology Presentation of a Cellular Variant of Breast Myofibroblastoma

Cited by 28 publications

References 4 publications

Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Fine-Needle Aspiration Cytology of Mammary Myofibroblastoma: A Report of Six Cases

Fine Needle Aspiration of Breast Myofibroblastoma

Cytomorphologic features that distinguish schwannoma from other low‐grade spindle cell lesions

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