Solitary Fibrous Tumor of the Skin

Cowper, Shawn E.; Kilpatrick, T. R.; Proper, Steven; Morgan, Michael B.

doi:10.1097/00000372-199906000-00001

Cited by 77 publications

(74 citation statements)

References 11 publications

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“…Recent papers report SFTs in the orbit [5], meninges [5], parotid and submandibular glands [6], lung [10], mediastinum [9], stomach and ileum [10], kidney [5], and skin [4,6], among other locations. SFTs are often asymptomatic, though large lesions may present with nonspecific clinical symptoms such as abdominal fullness or discomfort [8,11].…”

Section: Case Reportmentioning

confidence: 99%

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Primary lung carcinoma metastatic to a solitary fibrous tumor

2004

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Section: Case Reportmentioning

confidence: 99%

“…However, subsequent ultrastructural and immunohistochemical studies have shown the neoplastic cells to be fibroblastic or myofibroblastic in nature [2,3]. Cases occurring outside the pleura have been reported in virtually all organs, including soft tissues, upper respiratory tract, ovary, orbit, liver, and retroperitoneum [2,3,4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Primary lung carcinoma metastatic to a solitary fibrous tumor

2004

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“…Histologisch ähnliche Tumoren fanden sich in der Leber, der Haut und der Schilddrüse sowie nasopharyngeal und in den Meningen, sodass man von einem ubiquitären Auftreten dieser solitären fibrösen Tumoren sprechen kann [2,3,4,10,12]. Hauptsächlich sind diese Neoplasien jedoch im Thorax lokalisiert.…”

Section: Abb 2 ▲ Fall 1: Makroskopie Des Fibrösen Pleuratumors Mit Nunclassified

Gro�e solit�re fibr�se Tumoren der Pleura als Zufallsbefund

et al. 2004

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The solitary fibrous tumor (SFT) is a very rare and usually benign neoplasm. This tumor is mostly located in the thoracic cavity, but it has also been reported in numerous sites including liver, skin, and meninges. Due to its rarity diagnosis is often difficult. Accordingly, histopathological differentiation is of major importance. Solitary fibrous tumors consistently express CD 34 and react negatively to epithelial markers. This absence of expression of epithelial markers, especially cytokeratin, is also useful to distinguish these rare entities from sarcomatous mesotheliomas. The treatment of choice for solitary fibrous tumors is extensive surgical resection. Up to now there is no evidence that radiation and chemotherapy are effective. The local recurrence or onset of metastases depends on histologic parameters. In cases of benign classification (60-80%), the recurrence rate was only 2% after surgical excision. One-half of the patients with malignant tumors can be cured; the rest develop recurrences and metastases more often. Especially in those cases, emphasis should be placed on continual follow-up examination. We report two cases of a 65- and a 75-year-old male patient with huge intrathoracic solitary fibrous subpleural tumors, discovered incidentally on routine chest X-ray.

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“…Additionally, ultrastructural studies further support ®broblast-like rather than mesothelial features of these cells. The occurrence of this tumor in extraserosal sites including orbit, 2 upper respiratory tract, 1 nasopharyngeal sinuses, 3 periosteum, 4 soft tissues, 5 skin, 6 prostate, 7 meninges, 8 spinal cord, 9 ± 13 epiglottis, 14 liver, 15 and thyroid 16 suggest that a solitary ®brous tumor has a mesenchymal origin.…”

Section: Introductionmentioning

confidence: 99%

Spinal solitary fibrous tumor: seventh reported case and review of the literature

et al. 2001

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We present the clinical, radiological, and pathological features of a solitary ®brous tumor in the spinal cord. This case is the seventh spinal solitary ®brous tumor in the literature. The tumor caused clinical symptoms in a 70-year-old female, which indicated compression of the spinal cord. Magnetic resonance imaging showed an intradural extramedullary mass at T3 vertebral level. Surgically, the tumor was ®rm, in an intradural extramedullary location and attached to the dura. Histologically, the tumor was composed of spindle cells in a collagenrich matrix but exhibited regional variations. CD34 and vimentin were diusely positive during immunohistochemical stain testing. The tumor displayed no positive staining for epithelial membrane antigen, cytokeratin, S-100 protein, smooth muscle actin or desmin. The Ki-67 labeling index was low. Solitary ®brous tumors have been found in a variety of locations suggesting that a solitary ®brous tumor has a mesenchymal origin. This rare tumor should be considered in the dierential diagnosis of spinal tumors. Spinal Cord (2001) 39, 57 ± 60

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Solitary Fibrous Tumor of the Skin

Cited by 77 publications

References 11 publications

Primary lung carcinoma metastatic to a solitary fibrous tumor

Primary lung carcinoma metastatic to a solitary fibrous tumor

Gro�e solit�re fibr�se Tumoren der Pleura als Zufallsbefund

Spinal solitary fibrous tumor: seventh reported case and review of the literature

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