Spinal solitary fibrous tumor: seventh reported case and review of the literature

Abstract

We present the clinical, radiological, and pathological features of a solitary ®brous tumor in the spinal cord. This case is the seventh spinal solitary ®brous tumor in the literature. The tumor caused clinical symptoms in a 70-year-old female, which indicated compression of the spinal cord. Magnetic resonance imaging showed an intradural extramedullary mass at T3 vertebral level. Surgically, the tumor was ®rm, in an intradural extramedullary location and attached to the dura. Histologically, the tumor was composed of spindle cells in a collagenrich matrix but exhibited regional variations. CD34 and vimentin were diusely positive during immunohistochemical stain testing. The tumor displayed no positive staining for epithelial membrane antigen, cytokeratin, S-100 protein, smooth muscle actin or desmin. The Ki-67 labeling index was low. Solitary ®brous tumors have been found in a variety of locations suggesting that a solitary ®brous tumor has a mesenchymal origin. This rare tumor should be considered in the dierential diagnosis of spinal tumors. Spinal Cord (2001) 39, 57 ± 60

Solitary Fibrous Tumor of the Central Nervous System

“…2,3,6,13,207,218 Each of these atypical morphological features may be discernable in isolation or in various combinations. To date, at least 29 cases (13.18%) of SFT of CNS exhibiting 1 or more atypical features at presentation, 14,64,[86][87][88][89]91,94,101,104,109,110,112,116,129,136,139,156,164,171,174,176 and 5 tumors showing atypical features at recurrence 17,77,83,108,173 have been reported ( Table 1). The atypical features in the majority of the aforementioned cases were diffuse.…”

Dumbbell-type solitary fibrous tumor in the cervical spine

“…[1][2][3][4] At present, immunohistochemistry facilitates the otherwise problematic differential diagnosis of solitary fibrous tumor from other benign and malignant spindle cell neoplasms of the spinal cord. 4,9,10 We report here a rare case of a solitary fibrous tumor in the cervical spinal cord.…”

Recurrent solitary fibrous tumour in the cerebellopontine angle

“…Only 57 cases have been reported to date. 2, Amongst these reports there were 3 in the cerebellopontine angle (CPA), 2,19 15 in the spine, 2,4,6,8,13,17,18,22,24,32,[36][37][38][39][40] 27 in the supratentorial compartment, 2,5,7,[9][10][11][12][13][14][15][16]21,[26][27][28][29][30][31]34,35 3 in the ventricles 15,20,23 and 8 in the posterior fossa. 2,8,15,25,28,33 We present a case of SFT in the left CPA that recurred 3 years after total resection.…”