Solitary Fibrous Tumor/Hemangiopericytoma of Spinal Cord: A Retrospective Single-Center Study of 16 Cases

Wang, Junwen; Zhao, Kai; Han, Lin; Jiao, Liwu; Liu, Weihua; Xu, Yali; Niu, Hongquan; Ke, Chao; Shu, Kai; Lei, Ting

doi:10.1016/j.wneu.2018.12.004

Cited by 19 publications

(48 citation statements)

References 31 publications

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“…Our analysis found that WHO grade III was a predictor of recurrence. This research result is consistent with previously reported (3,4). A review of the literature found that tumor cells proliferated under a light microscope, some of the nuclei showed atypia, abundant blood vessels were located around the tumor cells, and some of the tumor cells showed typical "staghorn" blood vessels.…”

Section: Discussionsupporting

confidence: 92%

“…It has been reported in the literature that the 5-years RFS of HPC in the spinal canal is 76% (4) and the average RFS is 45.1 months (3). Tumor recurrence is significantly correlated with WHO level III (3,4). In addition, our findings indicate that the range of tumor resection also affects tumor recurrence.…”

Section: Discussionmentioning

confidence: 52%

“…A review of the literature found that tumor cells proliferated under a light microscope, some of the nuclei showed atypia, abundant blood vessels were located around the tumor cells, and some of the tumor cells showed typical "staghorn" blood vessels. Immunohistochemistry showed vimentin positivity in all tumors and CD34 positivity in most tumor cells (3,4). The effect of postoperative radiotherapy remains uncertain, and postoperative radiotherapy had no statistically significant effect on the survival rate of patients in this group.…”

Section: Discussionmentioning

confidence: 78%

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Case Report: A Review of the Literature on Spinal Intradural Hemangiopericytoma With Spinal Cord Infiltration and a Case Report

et al. 2020

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Purpose: Primary spinal intradural hemangiopericytoma (HPC) with spinal cord infiltration is rare. The purposes of this study were to investigate the clinical features of intradural HPC with spinal cord infiltration and to explore the related factors affecting tumor recurrence.Methods: We report a case of intramedullary HPC with intramedullary infiltration of the thoracic spine. The relevant literature was searched for with PubMed, and clinical data were extracted from the included studies. Clinical patient data were described and statistically analyzed. Then, Kaplan-Meier (KM) curves were used to describe the relapse-free survival (RFS) of patients in different groups, and the log-rank test was used for evaluation.Results: A total of 11 cases of spinal intradural HPC with spinal cord infiltration were included (including the case described in this report). Further data analysis showed that sex (P = 0.249), age (P = 0.876), tumor location (P = 0.524), and postoperative radiotherapy (P = 0.12) had no significant influence on RFS. The range of tumor resection (P = 0.004) and the WHO grade (P = 0.014) significantly affect the patient RFS.Conclusion: RFS was higher in patients with total tumor resection than in patients with subtotal tumor resection. The patients with lower WHO grade have better RFS. Total tumor resection is the primary objective of surgical treatment of spinal intradural HPC with spinal infiltration. Long-term postoperative follow-up is considered necessary.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 78%

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Case Report: A Review of the Literature on Spinal Intradural Hemangiopericytoma With Spinal Cord Infiltration and a Case Report

et al. 2020

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“…In addition, nuclear atypia, cell proliferation, and necrosis were also considered as manifestations of malignant SFT [35]. It has been reported that the percentage of Ki-67-positive cells tends to increase correspondingly in SFT with an invasive tendency, which is clinically signi cant for the selection of postoperative treatment plan and assessment of tumor prognosis [37,[39][40][41]. In three cases reported herein, tumor cells were spindle-shaped and densely distributed in collagen bers.…”

Section: Pathological Manifestationsmentioning

confidence: 82%

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Cui¹,

Wang²,

Cui³

et al. 2021

Preprint

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Purpose Solitary fibrous tumor (SFT) is a spindle cell neoplasm that rarely occurs in orbit. This study aimed to report clinical, imaging, and pathological features of three patients with recurrent orbital SFTs.Methods Clinical, imaging, and pathological data of the three patients were retrospectively reviewed, and the results were compared with those of previously reported cases with recurrent orbital SFT. Results One female and two male patients (mean age, 54 years old) were included in this study. The present cases and literature review showed that the average time to recurrence in patients who aged under 50 years old was shorter than that in those who aged over 50 years old. The most common site for recurrent orbital SFT was the retrobulbar area of the orbit (23.8%). Imaging examinations showed consistent intensity of MRI signals before and after recurrence. Immunohistochemical results of all cases revealed the expressions of CD34. The mitotic rate increased in 4/8 cases, and the percentage of Ki-67-positive cells was elevated in 5/16 cases. Conclusion These results suggested that young patients were more likely subjected to recurrent orbital SFT. The postoperative pathological diagnosis revealed that patients with recurrent orbital SFT had more nuclear abnormalities and mitotic activity, as well as a higher percentage of Ki-67-positive cells, indicating that orbital recurrent SFT tended to be malignant according to both morphological features and immunohistochemistry results.

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“…SFTs are well-known hypervascular tumors, and previous reports have described the benefit of preoperative embolization for such tumors [6] , [7] , [8] . Some reported that local recurrence seldom occurred if gross total resection was achieved [9 , 10] . However, once intratumor resection occurred, a high rate of local recurrence was observed, and the tumor will possibly be dedifferentiated [11 , 12] .…”

Section: Discussionmentioning

confidence: 99%

Combination therapy with preoperative embolization and en block laminectomy using thread saw for spinous process solitary fibrous tumor: A case report

Yamada

Hasegawa

Shido

et al. 2020

Radiology Case Reports

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Solitary fibrous tumors are rare mesenchymal neoplasms with highly recurrence rates after intratumor resection. We report 2 cases of solitary fibrous tumors treated with combination therapy with embolization and en bloc laminectomy using thread saw. To the best of our knowledge, this is the first such report. In the 2 cases, the hypervascular tumors were located in the spinal process and infiltrating the multifidus. Preoperative embolization was useful for decreasing intraoperative bleeding, and using thread saw was an ideal technique for deciding the cut surface height of the pedicle to achieve gross total resection.

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Solitary Fibrous Tumor/Hemangiopericytoma of Spinal Cord: A Retrospective Single-Center Study of 16 Cases

Cited by 19 publications

References 31 publications

Case Report: A Review of the Literature on Spinal Intradural Hemangiopericytoma With Spinal Cord Infiltration and a Case Report

Case Report: A Review of the Literature on Spinal Intradural Hemangiopericytoma With Spinal Cord Infiltration and a Case Report

Clinicopathological Characteristics of Three Cases with Recurrent Orbital Solitary Fibrous Tumors: A Retrospective Study and Literature Review

Combination therapy with preoperative embolization and en block laminectomy using thread saw for spinous process solitary fibrous tumor: A case report

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