Solitary extramedullary plasmacytoma and granulomatous sialadenitis of the parotid gland preceding a B-cell non-Hodgkin’s lymphoma

Gouveris, Haralampos; Hansen, Thorsten; Franke, KJ

doi:10.1007/s10006-006-0673-5

Cited by 8 publications

(9 citation statements)

References 11 publications

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“…As mentioned previously, histopathological analysis in isolation is insufficient to confirm a diagnosis of primary extramedullary plasmacytoma, since it is necessary to exclude the possibility of multiple myeloma through skeletal and marrow examinations, immunoelectrophoresis, quantitative immunoglobulin testing, and confirmation of the absence of urinary Bence Jones proteins ( 17 ). Cyclin D1 expression in EOP, as observed in the current patient, has been associated with an unfavourable prognosis in previous studies ( 19 ); however, this did not seem to be true of the present case. In addition, the distinction between plasmacytoma and lymphoma with extreme plasma cell differentiation may be challenging ( 1 , 2 ).…”

Section: Discussioncontrasting

confidence: 81%

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

González-Pérez

Infante-Cossio

Martín

2017

Molecular and Clinical Oncology

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Extraosseous plasmacytoma (EOP) is an uncommon malignant tumour that is characterised by the monoclonal proliferation of abnormal plasma cells in soft tissue; however, EOP lacks the defining features of multiple myeloma or medullary plasmacytoma. Although the majority of EOP lesions occur in the head and neck, EOP of the parotid gland is extremely uncommon. The present study aimed to explore the clinical features of parotid plasmacytoma, in addition to the diagnostic and therapeutic options for its management. Using the Medline database, a search was conducted for articles published on the topic of ‘parotid plasmacytoma’ up until the year 2016. A total of 20 cases were evaluated, including 19 clinical cases from the literature and 1 new clinical case from our hospital. Among the 19 previously published cases, the mean age at the time of diagnosis of EOP was 65.1±10.9 years (range, 38–78 years). Plasmacytomas were located unilaterally in all cases: On the right side in 9 patients (47.4%), on the left side in 10 patients (52.6%). Treatment included chemotherapy in 3 cases, radiotherapy in 11 cases and surgical removal in 15 cases. The diagnosis of EOP is based on the presence of a localised tumour comprising monoclonal plasma cells, and EOP is identical to multiple myeloma in this regard; however, EOP, in contrast to multiple myeloma, does not exhibit the signs that are indicative of disseminated disease, such as additional lesions on skeletal radiological examination, plasmacytosis in the bone marrow, and hypercalcaemia, anaemia, or renal failure. Thus, EOP must be considered in the differential diagnosis of parotid gland lesions in order to avoid confusion with other tumoural diseases.

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Section: Discussioncontrasting

confidence: 81%

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

González-Pérez

Infante-Cossio

Martín

2017

Molecular and Clinical Oncology

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“…The authors state that the combination of a SEP with a systemic connective tissue disorder is probably an indication of a generalized immunological defect. [ 9 ] In our patient, the underlying medical condition of mixed connective tissue disease suggests the same hypothesis. As of the authors' knowledge, this is the second reported case of SEP on a patient with a connective tissue disease.…”

Section: Discussionsupporting

confidence: 61%

“…The cyclin-D1 expression is known to have an unfavorable prognosis in patients with plasmacytomas, but in our case, this marker was negative. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease

Tatsis

Sotiropoulos

Baliaka

et al. 2021

J Oral Maxillofac Pathol

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“…First, PLCNA has been described in association with autoimmune connective tissue disorders. Second, association between CREST and solitary extramedullary plasmacytomas of the parotid gland has been reported 4 . As PLCNA is considered to be a type of isolated plasmacytoma, such association seems to be relevant.…”

mentioning

confidence: 94%

Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome

Shiman¹,

Ricotti²,

Kerdel³

et al. 2010

Int J Dermatology

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Solitary extramedullary plasmacytoma and granulomatous sialadenitis of the parotid gland preceding a B-cell non-Hodgkin’s lymphoma

Cited by 8 publications

References 11 publications

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

Primary extraosseous plasmacytoma of the parotid gland: A case report and literature review

Solitary extramedullary plasmacytoma of the parotid gland in a patient with mixed connective tissue disease

Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome

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