Primary localized cutaneous nodular amyloidosis associated with CREST (calcinosis, Raynaud's phenomenon, esophageal motility disorders, sclerodactyly, and telangiectasia) syndrome

Shiman, Michael I.; Ricotti, Carlos; Kerdel, Francisco A.; Romanelli, Paolo

doi:10.1111/j.1365-4632.2008.04058.x

Cited by 16 publications

(19 citation statements)

References 4 publications

(4 reference statements)

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“…There are three previously reported cases of LCNA in the setting of LSSc (Damian and Bertouch, 2010, Shiman et al, 2010, Summers and Kendrick, 2008). The features of the current and the previously reported cases are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 98%

“…In the cases that are presented in this study, all three patients had a diagnosis of LSSc when they presented with LCNA. In all reported cases, patients ranged in age from 58 to 83 years, were predominately female, and presented only with LCNA involvement of the unilateral or bilateral lower extremities (Damian and Bertouch, 2010, Meijer et al, 2008, Shiman et al, 2010, Summers and Kendrick, 2008). The follow-up time ranged from 1 to 9 years and no patient developed systemic amyloidosis.…”

Section: Discussionmentioning

confidence: 99%

“…However, there has been report of keratinocyte-derived amyloid (AK) that is implicated in LCNA (Cornejo et al 2015). Cutaneous macular and lichen amyloidoses are composed of amyloid K (Shiman et al 2010). …”

Section: Discussionmentioning

confidence: 99%

“…We hypothesize that the same could be true for LSSc. Others have hypothesized that LSSc may alter growth factors and cytokines that impair normal plasma cell function (Shiman et al 2010). Additionally, one could hypothesize that therapies to treat existing autoimmune connective tissue disease may lead to the development of LCNA but no data is available to support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis (Summers and Kendrick 2008) and may be associated with autoimmune connective tissue diseases such as Sjögren syndrome (SS; Meijer et al 2008) and limited systemic sclerosis (LSSc; formerly known as CREST syndrome; Damian and Bertouch, 2010, Shiman et al, 2010, Summers and Kendrick, 2008). We report three cases of LCNA in patients with LSSc and briefly review existing information in current literature.…”

Section: Introductionmentioning

confidence: 99%

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Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review

Goettsche

Moye

Tschetter

et al. 2017

International Journal of Women's Dermatology

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Localized cutaneous nodular amyloidosis (LCNA) is the rarest form of localized cutaneous amyloidosis. In patients with LCNA, local plasma cells secrete immunoglobulin light chains called amyloid L via an unknown mechanism. LCNA has been associated with autoimmune connective tissue diseases such as most commonly Sjögren syndrome. A few reported cases of LCNA are associated with limited systemic sclerosis (LSSc). We report three cases of LCNA in patients with LSSc to add to the existing literature, discuss the disease association and proposed pathophysiology, and briefly review the existing information in current literature. It is important to closely follow patients with LCNA to monitor progression to systemic amyloidosis.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Three cases of localized cutaneous nodular amyloidosis in patients with limited systemic sclerosis and a brief literature review

Goettsche

Moye

Tschetter

et al. 2017

International Journal of Women's Dermatology

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Asymptomatic Cobblestoned Plaques on the Soles

2017

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A man in his 60s with diabetes underwent biopsy for an asymptomatic shiny indurated plaque on the right plantar foot, which had been slowly growing for the past year. The patient was then referred to a dermatology specialist for further treatment. The patient reported no fevers, chills, weight loss, or night sweats. He had long-standing, intermittent dyspnea on exertion, but no baseline shortness of breath, orthopnea, or bilateral lower extremity edema. The patient had occasional numbness in both legs in stocking distribution, attributed to diabetic neuropathy. Physical examination revealed a 4.5 cm waxy, nontender, smooth-surfaced, cobblestoned plaque located in the sulcus between the second and fourth toes (Figure , A). A biopsy specimen obtained by the patient's podiatrist was sent to the dermatopathology laboratory for review. Clinical image A Histopathologic image B Histopathologic image C Figure. A, Clinical presentation revealed smooth-surfaced cobblestoned plaque that was asymptomatic. B, Hemotoxylin-eosin stain (original magnification ×100) results show a diffuse infiltrate of pale eosinophilic material with prominent clefts. C, Congo red stain (original magnification ×200). WHAT IS YOUR DIAGNOSIS? A. Pseudolymphoma B. Elephantiasis nostras verrucosa C. Plantar cerebriform collagenoma D. Nodular amyloid Clinical Review & Education

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