Solitary epithelioid histiocytoma (reticulohistiocytoma) of the glans penis

Mannan, Abul Ala Syed Rifat; Kahvic, Mirza; Singh, Naorem Gopendro; Zahir, Mohammed

doi:10.1007/s11255-012-0248-3

Cited by 10 publications

(13 citation statements)

References 6 publications

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“…It usually affects young adults with a slight female predominance and can be observed in all age ranges [2]. So far, no more than ten cases of head and neck reticulohistiocytoma have been reported [1][2][3][4][5][6][7]. Here, we have described an unusual polypoid presentation of solitary reticulohistiocytoma on the scalp of a healthy 25-year-old woman.…”

Section: Discussionmentioning

confidence: 99%

Solitary orange‐yellow scalp lesion

Zheng

Han

Huang

2015

J Deutsche Derma Gesell

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HistoryA healthy 25-year-old woman was referred for evaluation of a scalp lesion that had been present for six months. The patient had no other skin lesions. Examination revealed a firm, smooth, pedunculated, orange-yellow nodule (Figure 1). There was no head and neck lymphadenopathy. Computed tomographic results of the skull and other organs were negative. A complete resection was performed. The patient has experienced no recurrence after 9-month follow-up. Figure 1 A round, projecting orange-yellow nodule with a smooth surface located on the scalp.

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Section: Discussionmentioning

confidence: 99%

Solitary orange‐yellow scalp lesion

Zheng

Han

Huang

2015

J Deutsche Derma Gesell

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“…Reticulohistiocytosis can present in 3 clinical settings (Table 1) [1][2][3][4][5][6][7][8][9]. Multicentric reticulohistiocystosis describes the occurrence of numerous cutaneous reticulohistiocytomas, frequently presenting as nodules on the hands and face, with an accompanying symmetric arthritis.…”

Section: Discussionmentioning

confidence: 99%

Adult-onset reticulohistiocytoma presenting as a solitary asymptomatic red knee nodule: report and review of clinical presentations and immunohistochemistry staining features of reticulohistiocytosis

Cohen

Lee²

2014

Dermatology Online Journal

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Reticulohistiocytomas are benign dermal tumors that usually present as either solitary or multiple, cutaneous nodules. Reticulohistiocytosis can present as solitary or generalized skin tumors or cutaneous lesions with systemic involvement and are potentially associated with internal malignancy. A woman with a solitary red nodule on her knee is described in whom the clinical differential diagnosis included dermatofibroma and amelanotic malignant melanoma. Hematoxylin and eosin staining and immunoperoxidase studies of the biopsy specimen established the diagnosis of adult-onset reticulohistiocytoma (solitary epithelioid histiocytoma). Reticulohistiocytoma is characterized by mononuclear, and occasionally multinuclear, histiocytes with eosinophilic "glassy" cytoplasm. The immunohistochemical profile of a reticulohistiocytoma demonstrates consistent positive expression for CD68 (a marker that is expressed by histiocytes but can also show positive staining in melanomas and carcinomas), CD163 (a very specific marker for histiocytes), and vimentin. Reticulohistiocytomas show variable positive expression for MITF (microphthalmia transcription factor) and S100 protein, both of which are more commonly used as markers for melanocytes. Recurrence of a reticulohistiocytoma is rare, even for patients with an incompletely removed lesion. However, our patient elected to have her residual tumor completely excised.

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“…1,6,20 The literature also describes cases of extracutaneous SSsf-RH involving the eye, orbit, central nervous system oral mucosa or penis. [38][39][40][41][42] SSsf-RH is a benign and sometimes self-healing condition that rarely recurs. 20 Dermatological differential diagnosis includes mastocytoma, early phase of xanthogranuloma, DRDD, atypical fibroxanthoma, Spitz naevus and pyogenic granuloma.…”

Section: Single-system Single Focal Reticulohistiocytosis: Cutaneous mentioning

confidence: 99%

“…a,b) . The literature also describes cases of extracutaneous SSsf‐RH involving the eye, orbit, central nervous system oral mucosa or penis . SSsf‐RH is a benign and sometimes self‐healing condition that rarely recurs .…”

Section: Clinical Findings and Systemic Associationsmentioning

confidence: 99%

Reticulohistiocytoses: a revision of the full spectrum

Bonometti

Berti

Onlus³

2020

Acad Dermatol Venereol

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Reticulohistiocytoses (RH) are rare and clinically heterogeneous histiocytic disorders of dermatological interest. Three clinical entities with superimposable histopathological features are currently considered, namely solitary reticulohistiocytoma, diffuse/generalized reticulohistiocytosis and multicentric reticulohistiocytosis. Although in the last decade, RH studies have only minimally progressed, histiocytosis research has advanced considerably: the prognostic and therapeutic importance of the clinical subclassification of histiocytosis patients as well as of the detection of genetic alterations in the genes of the ERK pathway has been highlighted. According to these insights, we previously reported the presence of molecular alteration RH and described a subset of patients with disseminated multisystem involvement lacking arthritis. In the present review, we aim to update and revise the knowledge regarding RH. We first reviewed their histopathological, immunophenotypical and ultrastructural features, discussed their histopathological differential diagnosis with other conditions characterized by infiltrates made of oncocytic or epithelioid cells (with special regard to Destombes-Rosai-Dorfman disease) and finally summarized the molecular landscape of RH. We therefore tried to adjust the clinical subclassification of Langerhans cell histiocytosis to the clinical phenotypes of RH, outlining five clinically different groups of patients. Finally, we reconsidered the clinical workflow to the evaluation of RH patients, in light of the 5 different clinical groups and discussed the different therapeutic approaches and the possible role of target inhibitors.

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Solitary epithelioid histiocytoma (reticulohistiocytoma) of the glans penis

Cited by 10 publications

References 6 publications

Solitary orange‐yellow scalp lesion

Solitary orange‐yellow scalp lesion

Adult-onset reticulohistiocytoma presenting as a solitary asymptomatic red knee nodule: report and review of clinical presentations and immunohistochemistry staining features of reticulohistiocytosis

Reticulohistiocytoses: a revision of the full spectrum

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