Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature

Abstract

Patients with endometrial adenocarcinoma presenting an isolated skeletal metastasis may exhibit an unusual group with a better prognosis.

Endometrial adenocarcinoma recurrence presenting with tibial metastasis: Report of a case

“…In an autopsy study, the corresponding frequency was 25–75% [6]. Bone metastasis are mostly seen as recurrence and survival is better when compared to those who sustained solitary bone metastasis at primary diagnosis [1], [7].…”

“…Endometrial adenocarcinoma presenting with a bone metastasis at the first diagnosis is rarely seen. Usually first sign is abnormal uterine bleeding and pelvic pain, yet endometrial adenocarcinoma diagnosed after tibial metastases have been reported in 7 cases up to now [1], [3], [9], [10], [11], [12], [13]. Metastatic bone disease is usually seen after first diagnosis of endometrial adenocarcinoma and duration between diagnosis and metastasis is 6 months to 5 years [6].…”

“…Malignancies originating from uterine tissue can metastase to several organs with a predilection to lungs and liver. Metastasis to skeletal system is extremely rare and mostly have been reported to be in axial skeleton [1].…”

“…There for surgeons generally tends to seek for a primary tumor originating from these organs [1], [2]. However although it is very rare, solitary bone lesions has been reported to be even first presentation site of a previously cured endometrial adenocarcinoma.…”

Metastasis of lung adenocarcinoma to the fifth distal phalange of right hand

“…There is marginal benefit on survival with chemotherapy and radiotherapy is effective in reducing local recurrence and controlling cancer-related pain as well as haemorrhage. Other option includes amputation, which should be considered in case of uncontrollable pain, haemorrhaged or serious infection 7–9. Reconstructive surgery is not recommended due to poor prognosis.…”