Solidification of oil liquids by encapsulation within porous hollow silica microspheres of narrow size distribution for pharmaceutical and cosmetic applications

Belostozky, Anna; Bretler, Sharon; Kolitz‐Domb, Michal; Grinberg, Igor; Margel, Shlomo

doi:10.1016/j.msec.2018.12.093

Cited by 27 publications

(14 citation statements)

References 21 publications

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“…The microspheres have skeleton structures with a uniform dispersion of active ingredients in the matrix of polymers. Microspheres have average particle sizes of l–1000 μm and are widely applied in food, medicine, cosmetics, and other fields. − There are three stages for the release of nutraceuticals into the medium from microspheres. The nutraceuticals on the surface of the microspheres dissolves and diffuses into the medium in the first stage.…”

Section: Preparation Of Nutraceutical Delivery System By Microfluidic...mentioning

confidence: 99%

Microfluidic Assembly: An Innovative Tool for the Encapsulation, Protection, and Controlled Release of Nutraceuticals

Liu

Singh

Zhang

et al. 2021

J. Agric. Food Chem.

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Nutraceuticals have been gradually accepted as food ingredients that can offer health benefits and provide protection against several diseases. It is widely accepted due to potential nutritional benefits, safety, and therapeutic effects. Most nutraceuticals are vulnerable to the changes in the external environment, which leads to poor physical and chemical stability and absorption. Several researchers have designed various encapsulation technologies to promote the use of nutraceuticals. Microfluidic technology is an emerging approach which can be used for nutraceutical delivery with precise control. The delivery systems using microfluidic technology have obtained much interest in recent years. In this review article, we have summarized the recently introduced nutraceutical delivery platforms including emulsions, liposomes, microspheres, microgels, and polymer nanoparticles based on microfluidic techniques. Emphasis has been made to discuss the advantages, preparations, characterizations, and applications of nutraceutical delivery systems. Finally, the challenges, several up-scaling methods, and future expectations are discussed.

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Section: Preparation Of Nutraceutical Delivery System By Microfluidic...mentioning

confidence: 99%

Microfluidic Assembly: An Innovative Tool for the Encapsulation, Protection, and Controlled Release of Nutraceuticals

Liu

Singh

Zhang

et al. 2021

J. Agric. Food Chem.

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“…The optimum time for the reaction was suggested to be 10 h and the temperature did not significantly affect the coating of PS. Belostozky et al [ 97 ] synthesised hollow silica spheres via multiple coatings. TEOS was replenished every 18 h to form three layers of silica.…”

Section: Polystyrene Coatingmentioning

confidence: 99%

Hollow Silica Nano and Micro Spheres with Polystyrene Templating: A Mini-Review

et al. 2022

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Synthesis of monodisperse hollow silica nanospheres, especially using a hard template route, has been shown to be successful, but a high yield is needed for this strategy to be used on an industrial scale. On the other hand, there is a research gap in the synthesis of hollow silica microspheres due to the popularity and easiness of the synthesis of silica nanospheres despite the larger spheres being beneficial in some fields. In this review, current trends in producing hollow silica nanospheres using hard templates, especially polystyrene, are briefly presented. Soft templates have also been used to make highly polydisperse hollow silica spheres, and complex designs have improved polydispersity. The effect of the main parameters on the coating is presented here to provide a basic understanding of the interactions between the silica and template surface in the absence or presence of surfactants. Surface charge, surface modification, parameters in the sol–gel method and interaction between the silica and templates need to be further improved to have a uniform coating and better control over the size, dispersity, wall thickness and porosity. As larger organic templates will have lower surface energy, the efficiency of the micro sphere synthesis needs to be improved. Control over the physical structure of hollow silica spheres will open up many opportunities for them to be extensively used in fields ranging from waste removal to energy storage.

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“…, Fragaria ananassa Duch ., etc.) , jojoba ( Simmondsia chinensis ) and coffee ( Coffea arabica L.) . Since jojoba oils can act as carrier oils for essential oils and lipophilic chemicals (e.g.…”

Section: Oils and Essential Oilsmentioning

confidence: 99%

“…Porous hollow silica particles are also frequently used in the sphere‐based encapsulation. Jojoba oil‐filled silica microsphere has shown as a promising solution for unstable active compounds for topical administration and hydrophilic formulation . Production techniques include spray‐drying, phase separation and coacervation.…”

Section: Particulate Systemmentioning

confidence: 99%

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

Yang

Liu

Han

et al. 2020

Intern J of Cosmetic Sci

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Today, there is a rising demand and ongoing search for novel plant-derived phytochemicals in the cosmetic market owing to the growing consumer expectations worldwide for green and natural health products. Various plant ingredients, including polyphenols, oils, volatile oils, vitamins and other herbal extracts, have been extensively used in herbal cosmetics. Recent advances in encapsulation technologies have greatly improved their chemical stability, biocompatibility, skin permeability and dermocosmetic efficiency when applied topically. This comprehensive review summarizes the up-to-date information on encapsulated plant ingredients tailored for dermocosmetic application with a focus on the development of novel delivery systems. An overview of the commonly used techniques for carrier characterization, performance-related properties and toxicological evaluation is also included, which might provide guidance for researchers to select or develop appropriate assay systems. PolyphenolsPolyphenols are secondary metabolites in plants, and the presence of the array of phenolic hydroxyl groups makes them potent free radical scavengers and antioxidants, which are favoured in antiageing cosmetics [1]. Encapsulation techniques are primarily employed to stabilize the easily reducible polyphenolic compounds during storage and processing, thereby enabling their cosmetic/ pharmaceutical uses. A good example is quercetin, a flavonoid from Sophora japonica L. with a pronounced antioxidative and anti-inflammatory activity but with poor water solubility and low skin

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Solidification of oil liquids by encapsulation within porous hollow silica microspheres of narrow size distribution for pharmaceutical and cosmetic applications

Cited by 27 publications

References 21 publications

Microfluidic Assembly: An Innovative Tool for the Encapsulation, Protection, and Controlled Release of Nutraceuticals

Microfluidic Assembly: An Innovative Tool for the Encapsulation, Protection, and Controlled Release of Nutraceuticals

Hollow Silica Nano and Micro Spheres with Polystyrene Templating: A Mini-Review

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

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