Solid-type primary intraosseous squamous-cell carcinoma in the mandible: Report of a rare case

Abstract

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that has an exquisitely exclusive affection to the jawbone. It is defined as squamous cell carcinoma arising within the jaw and developing from residual odontogenic epithelium or from a preexisting odontogenic cyst or tumor. The solid-type of this tumor is a central jaw carcinoma arising de novo and has no initial connection with the oral mucosa. Herein, we report a case of solid-type PIOSCC involving the mandible in a 37-year-old male patient elucidating its histopathological and imaging findings. The patient underwent surgical resection followed by post-operative adjuvant radiotherapy. The close 2-year follow up of the patient revealed neither locoregional nor distant metastasis.

Solid type primary intraosseous squamous cell carcinoma in a cat

“…The proposed diagnosis of solid type PIOSCC in this cat was further supported by the radiographic findings, which revealed an osteolytic lesion associated with tooth resorption; this outcome was similar to the typical radiographic appearance of human solid type PIOSCC [ 6 , 15 , 16 ].…”

Primary intraosseous carcinoma in the parasymphyseal region of mandible: A case report and review

“…[3] Hence, to confirm the diagnosis of solid de novo PIOC, the specimen should be thoroughly examined to confirm that there is no evidence of odontogenic cysts or other odontogenic tumor components. [12] In the present case, the histopathological sections revealed islands of tumor cells with dysplastic features with no contact with the above mucosal/surface epithelium and carcinoma also showed an intimate connection to the surgical extracted site. There was no pre-existing odontogenic cyst in the patient, suggesting that this case was a primary de novo intraosseous keratinizing SCC.…”

“…Hence, the neoplasms that originate from squamous epithelium are considered under differential diagnosis. [12] Shear proposed that the histologic picture of PIOC will that be of SCC with the absence of keratinization, but Elzay has contradicted that it is not necessary that PIOCs are non-keratinized SCCs, but rather they can also be keratinized. [13,14] The present case is characterized by keratinizing type of PIOC.…”

Primary intraosseous carcinoma, NOS in a 17‐year‐old male: case report and literature review

“…First described in 1913 by Loos, as a central epidermoid carcinoma of the jaw, it has had many nomenclature modifications since, but in 2005 the World Health Organization (WHO) settled on primary intraosseous squamous cell carcinoma (SCC), and described three subcategories of this tumour. These included: type 1, a solid tumour that invades marrow spaces and induces osseous resorption; type 2, squamous cancer arising from the lining of an odontogenic cyst and type 3, a SCC arising in a benign epithelial odontogenic tumour. In 2017, the WHO simplified its classification, to PIOC, NOS and discarded the three subcategories.…”

“…PIOC is more commonly found in the posterior mandible, and when located in the maxilla, it is most often anterior. Regional lymphadenopathy may occur in PIOC, and has been described more in the solid, de novo type (36.5%) versus those from cystic origin (4.4%).…”