Solid-state synthesis and characterization of the ternary phase Ti3SiC2

Racault, C.; Langlais, F.; Naslain, R.

doi:10.1007/bf00352037

Cited by 312 publications

(142 citation statements)

References 15 publications

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“…Powder X-ray diffraction analysis was performed to verify new solid state formation [29]. P-XRD analysis was conducted for unprocessed FTD and processed FTD (FFSe-4) using an X-ray diffractometer JDX-3532 (JEOL Japan).…”

Section: Powder X-ray Diffraction (P-xrd)mentioning

confidence: 99%

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

Shafique

Khan

et al. 2017

Journal of Nanomaterials

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Famotidine as H 2 receptor has antagonistic effects on gastric secretion. Unfortunately, its hydrophobic nature contributes to its variable and poor oral bioavailability. In the current study efforts are being made to fabricate famotidine loaded solid lipid nanoparticles with narrow size distribution. Prepared nanoformulations were pharmaceutically evaluated to confirm the desired boosted oral bioavailability. Famotidine loaded nanoformulation (FFSe-4) showed particle size 111.9±1.3 nm, polydispersity index 0.464 ± 0.03, zeta potential −33.46 ± 2 mV, entrapment efficiency 84 ± 2.7%, and drug loading capacity 2.709 ± 0.13%. Drugexcipients compatibility was confirmed by Fourier transformed infrared spectroscopy. Scanning electron microscopy confirmed spherical shaped, nanosized particles. Differential scanning calorimetry and powder X-ray diffractometry confirmed the change in crystalline nature. Prepared nanoformulation was more stable at refrigerated temperature. In vitro study showed that drug release time is proportional to drug pay load and followed zero order kinetics. Release exponent ( > 0.5) confirmed non-Fickian-diffusion mechanism for drug release. In vivo pharmacokinetic studies showed 2.06-fold increase in oral bioavailability of famotidine dispersed in solid lipid nanoparticles compared to commercial product. These results authenticate solid lipid nanoparticles as drug delivery system and propose prolonged release with improved oral bioavailability for famotidine.

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Section: Powder X-ray Diffraction (P-xrd)mentioning

confidence: 99%

Fabrication, Characterization, and In Vivo Evaluation of Famotidine Loaded Solid Lipid Nanoparticles for Boosting Oral Bioavailability

Shafique

Khan

et al. 2017

Journal of Nanomaterials

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“…Since then, several processing techniques have been developed to synthesize single-phase, bulk, polycrystalline Ti 3 SiC 2 . These processing techniques include arc melting [5], direct sintering [6], reactive hot-pressing (HP) [1], hot-isostatic pressing (HIP) [3], spark plasma sintering (SPS) [7], pulse discharge sintering (PDS) [8] and self-propagating high-temperature synthesis (SHS) [9]. A variety of precursor materials viz.…”

Section: Introductionmentioning

confidence: 99%

Reaction synthesis of Ti3SiC2 phase in plasma sprayed coating

Pasumarthi

Chen

Bakshi

et al. 2009

Journal of Alloys and Compounds

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“…1 In recent decades, to synthesize Ti 3 SiC 2 samples, various processes including: (1) chemical vapor deposition; 2 (2) arc-melting method; 3 (3) Hot-isolated-pressing (HIP) or spark plasma sintering (SHS) method; 4À9 and (4) reactive sintering method; 10À13 were employed or developed. In the earlier sintering methods, most investigators preferred to fabricate this material by using the elemental powders of Ti/Si/C with different molar ratios, such as Lis et al, 5,6 Li et al, 7,8 Gao et al , 9 Racault et al, 10 Radhakrishnan et al, 11 Zhou and Sun. 12,13 However, it is noted that their sintering processes were often performed at relatively high temperature (more than 1400 C) for a long time.…”

Section: Introductionmentioning

confidence: 99%