Solid-State NMR Studies of Bone

Kołodziejski, Wacław

doi:10.1007/b98652

Cited by 85 publications

(101 citation statements)

References 37 publications

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“…The CP contact time was set to 500 µs in order to attenuate the intensity of the apatite signal at 1 H and 31 P chemical shifts of 0.2 and 2.8 ppm, respectively. [52] In addition, there are four distinct spectral components at 1 Asp-24h…”

Section: Solid-state Nmrmentioning

confidence: 99%

Solid‐state P‐31 NMR study of the formation of hydroxyapatite in the presence of glutaric acid

Tseng

Mou

Chen

et al. 2008

Magnetic Reson in Chemistry

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We demonstrate that glutaric acid can be used to prepare nanorods of hydroxyapatite under hydrothermal condition at 100 degrees C with a Ca(2+):glutaric acid molar ratio of 1:4. Frequency-switched Lee-Goldburg irradiation is employed to obtain high-resolution (31)P{(1)H} correlation spectra of the reaction mixture at two different reaction periods, from which it is shown that octacalcium phosphate is the precursor phase of the final hydroxyapatite product. In addition, the spectra show that a substantial amount of water molecules is trapped between the glutaric acid and the hydroxyapatite surface, indicating that water molecules may play a prominent role in the noncovalent interaction of the glutaric acid and the HAp surface.

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Section: Solid-state Nmrmentioning

confidence: 99%

Solid‐state P‐31 NMR study of the formation of hydroxyapatite in the presence of glutaric acid

Tseng

Mou

Chen

et al. 2008

Magnetic Reson in Chemistry

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“…CO 3 2-is a very important substitution and although substitution levels of other ions can be very low they can have a strong influence on the functional properties. Although solid state NMR is an obvious probe of the atomic scale substitutions in apatite-based natural materials and although some studies were performed some time ago it is only recently that NMR has emerged as a key analytical tool for these materials [87].…”

Section: Biomaterialsmentioning

confidence: 99%

Recent technique developments and applications of solid state NMR in characterising inorganic materials

Hanna

Smith

2010

Solid State Nuclear Magnetic Resonance

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A broad overview is given of some key recent developments in solid state NMR techniques that have driven enhanced applications to inorganic materials science. Reference is made to advances in hardware, pulse sequences and associated computational methods (e.g. first principles calculations, spectral simulation), along with their combination to provide more information about solid phases. The resulting methodology has allowed more nuclei to be observed and more structural information to be extracted. Cross referencing between experimental parameters and their calculation from the structure has seen an added dimension to NMR as a characterisation probe of materials. Emphasis is placed on the progress made in the last decade especially from those nuclei that were little studied previously. The general points about technique development and the increased range of nuclei observed are illustrated through a range of specific exemplars from inorganic materials science.

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“…Solid-state nuclear magnetic resonance (NMR) spectroscopy is ideally suited for the characterization of disordered or nanoscale materials and has been shown to provide important structural information in natural dentine [12,13], cartilage [14], and bone minerals [15][16][17][18] and their model compounds [19][20][21][22][23]. The presence of certain moieties known to exist in calcified tissues such as calcium phosphates, hydroxide groups, and water molecules as well as their arrangement and order, can be examined using 31 P and 1 H solid-state NMR.…”

Section: Introductionmentioning

confidence: 99%

Early Stages of Biomineral Formation—A Solid-State NMR Investigation of the Mandibles of Minipigs

et al. 2017

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Solid-state nuclear magnetic resonance (NMR) spectroscopy allows for the identification of inorganic species during the biomineral formation, when crystallite particles visible in direct imaging techniques have not yet been formed. The bone blocks surrounding dental implants in minipigs were dissected after the healing periods of two, four, and eight weeks, and newly formed tissues formed around the implants were investigated ex vivo. Two-dimensional 31 P-1 H heteronuclear correlation (HETCOR) spectroscopy is based on the distance-dependent heteronuclear dipolar coupling between phosphate-and hydrogen-containing species and provides sufficient spectral resolution for the identification of different phosphate minerals. The nature of inorganic species present at different mineralization stages has been determined based on the 31 P chemical shift information. After a healing time of two weeks, pre-stages of mineralization with a rather unstructured distribution of structural motives were found. After four weeks, different structures, which can be described as nanocrystals exhibiting a high surface-to-volume ratio were detected. They grew and, after eight weeks, showed chemical structures similar to those of matured bone. In addition to hydroxyapatite, amorphous calcium phosphate, and octacalcium phosphate, observed in a reference sample of mature bone, signatures of ß-tricalcium phosphate and brushite-like structures were determined at the earlier stages of bone healing.

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Solid-State NMR Studies of Bone

Cited by 85 publications

References 37 publications

Solid‐state P‐31 NMR study of the formation of hydroxyapatite in the presence of glutaric acid

Solid‐state P‐31 NMR study of the formation of hydroxyapatite in the presence of glutaric acid

Recent technique developments and applications of solid state NMR in characterising inorganic materials

Early Stages of Biomineral Formation—A Solid-State NMR Investigation of the Mandibles of Minipigs

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