Solid‐state NMR Spectroscopy

Characterization of Mannitol Polymorphic Forms in Lyophilized Protein Formulations Using a Multivariate Curve Resolution (MCR)-Based Raman Spectroscopic Method

“…In principle, specific polymorphic forms can be identified and quantified by using X-ray powder diffractometry (XRPD) (7,11), vibrational spectroscopic techniques including IR (12), NIR (13), Raman (14)(15)(16), solid-state NMR (17), and thermoanalytical methods like differential scanning calorimetry (DSC) (18). The use of XRPD may be limited by uncertainty in peak intensity caused by preferred orientation and limited sensitivity, even though it is still the most popular technique used for polymorphic identification.…”

Detection of Chiral Defects in Crystalline Organic Solids Using Solid-State NMR Spectroscopy

“…14,15 Additionally, SSNMR has been successfully applied to the analysis of chiral and achiral solid solutions, 16,17 and in general, is particularly useful for the identification of different solid forms. 18 Proline was chosen as a model chiral compound for these studies. It has several benefits as a model compound, including (1) one chiral center in the molecule;…”

Detection of low-level PTFE contamination: An application of solid-state NMR to structure elucidation in the pharmaceutical industry

“…SSNMR is becoming an increasingly important tool for studying polymorphism of drugs [2,3], which was in fact the original aim of this work. At GlaxoSmithKline, SSNMR has continuously expanded from studies of polymorphs and solvates of APIs [4] to more advanced studies of organic co-crystals and complexes [5,6] and determination of crystal structure from powder samples [7].…”