Solid-state NMR in the field of drug delivery: State of the art and new perspectives

APTES-Modified SBA-15 as a Non-Toxic Carrier for Phenylbutazone

“…The 1 H-NMR results confirm that loaded phenylbutazone in the SBA-15 mesopores undergoes structural rearrangements upon transition from the crystalline state to the amorphous one, which improves the bioavailability of the drug [ 40 , 41 ].…”

New Development in Understanding Drug–Polymer Interactions in Pharmaceutical Amorphous Solid Dispersions from Solid-State Nuclear Magnetic Resonance

“…Solid-state nuclear magnetic resonance (NMR) has emerged as a significantly powerful tool to access structural and dynamics information across the biological, chemical, material, and physical sciences. , In particular, despite the high cost of the equipment, NMR is arguably the most powerful approach to obtain structural information at the atomic level and is complementary to the analytical techniques mentioned above. NMR plays an important role in pharmaceutical sciences , to enable the structural understanding of the API and polymer, , identify crystalline polymorphs, monitor drug recrystallization phenomena from amorphous systems, and understand API–polymer interactions in ASDs. − Although a number of reviews has been published on these topics, these papers report either broad overviews − or specific applications in the field (e.g., 19 F) . This Review aims to describe the use of solid-state NMR to the understanding of the stability of ASDs based on the presence of API–polymer interactions and highlights the most modern NMR methodologies to achieve this.…”

“…NMR plays an important role in pharmaceutical sciences 22 , 23 to enable the structural understanding of the API 24 and polymer, 25 , 26 identify crystalline polymorphs, 27 monitor drug recrystallization phenomena from amorphous systems, and understand API–polymer interactions in ASDs. 28 − 38 Although a number of reviews has been published on these topics, these papers report either broad overviews 39 − 41 or specific applications in the field (e.g., 19 F). 42 This Review aims to describe the use of solid-state NMR to the understanding of the stability of ASDs based on the presence of API–polymer interactions and highlights the most modern NMR methodologies to achieve this.…”

“…The value of the spin diffusion coefficient D can be either calculated from eq 2 , in which I 0 is the distance between protons in the sample (typically in the range of 0.1 nm) and T 2 is the transverse relaxation time, 41 or found in the literature from a variety of sources on rigid and mobile polymers ( D values ranging from 0.5 × 10 –12 64 to 8.0 × 10 –12 cm 2 s –1 65 are available). …”

Rapid Structural Analysis of Minute Quantities of Organic Solids by Exhausting 1H Polarization in Solid-State NMR Spectroscopy Under Fast Magic Angle Spinning

“…Via selective manipulation of the spin interactions among nuclei, solid-state nuclear magnetic resonance (NMR) spectroscopy is able to reveal the structural information at a length scale from 0.1 nm to about 100 nm and dynamic information at a time scale from about 1 ps to about 100 s in solids . Therefore, solid-state NMR has been playing a significant and indispensable role in providing atomic-level insights into the structures and dynamics of a wide variety of challenging systems over the past few decades, including polymers, , proteins, drug delivery, and so on. Nevertheless, the inherent low sensitivity of solid-state NMR has severely limited the application range of this mighty technique due to the failure of utilizing the great benefits of sophisticated multidimensional solid-state NMR experiments.…”