APTES-Modified SBA-15 as a Non-Toxic Carrier for Phenylbutazone

Abstract

Improvement of the bioavailability of poorly soluble medicinal substances is currently one of the major challenges for pharmaceutical industry. Enhancing the dissolution rate of those drugs using novel methods allows to increase their bioavailability. In recent years, silica-based mesoporous materials have been proposed as drug delivery systems that augment the dissolution rate. The aim of this study was to analyse the influence of phenylbutazone adsorption on SBA-15 on its dissolution rate. Moreover, we examined the cytotoxicity of the analyzed silica. The material was characterized by SEM, TEM, DSC, 1H-NMR, XRD, and FT-IR. The phenylbutazone did not adsorb on unmodified SBA-15, while the adsorption on APTES-modified SBA-15 resulted in 50.43 mg/g of loaded phenylbutazone. Phenylbutazone adsorbed on the APTES-modified SBA-15 was then released in the hydrochloric acidic medium (pH 1.2) and phosphate buffer (pH 7.4) and compared to the dissolution rate of the crystalline phenylbutazone. The release profiles of the amorphous form of adsorbed phenylbutazone are constant in different pH, while the dissolution rate of the crystalline phenylbutazone depends on the pH. The cytotoxicity assays were performed using the Caco-2 cell line. Our results indicate that the analyzed material ensured phenylbutazone adsorption in an amorphous state inside the mesopores and increased its dissolution rate in various pH levels. Furthermore, the cytotoxicity assay proved safety of studied material. Our study demonstrated that APTES-modified SBA-15 can serve as a non-toxic drug carrier that improves the bioavailability of phenylbutazone.

DNA Adsorption Capabilities of Amine Functionalized Magnetic Cellulose Acetate Butyrate Beads from Aqueous Solution

“…The antisymmetric and symmetric stretching vibrations of methylene group peaks of N−mCABs and CABS were observed at around 2900 cm −1 and 2800 cm −1 , respectively [32,33] . After the surface modification of mCABs with APTES, the new peak observed at around 1550 cm −1 was assigned to N−H bending vibrations [34] …”

“…[32,33] After the surface modification of mCABs with APTES, the new peak observed at around 1550 cm À 1 was assigned to NÀ H bending vibrations. [34] The SEM images of NÀ mCABs and CABs were illustrated in Figure 2 and as depicted in Figure 2 (A and C) the surfaces of both beads were smooth; however, their inner parts were rough and the central of NÀ mCABs (D) were quite different as compared to CABs (B), probably, the addition of magnetic nanopowders could result in changing the central of NÀ mCABs. On the other hand, both microbeads had channel-like morphologies (B and D) and their channel-like structures found inner sides may be due to the coagulation bath used during the preparation process of the modified and unmodified beads.…”

Antioxidant-Loaded Mesoporous Silica—An Evaluation of the Physicochemical Properties

“…All antioxidants were characterized by sharp patterns with high intensity due to the fact of their crystalline structure. Samples of antioxidant-loaded SBA-NH2 materials revealed a broad halo in the 2-theta range of 15–30 degrees, which is characteristic of amorphous silica [ 63 ]. Highly reduced intensities of main peaks characteristic of GA were observed in the pattern of the SBA-NH2-GA sample.…”

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

“…With a high specific surface area (700–1000 m 2 /g) [ 70 , 71 ], MSNs have high drug loading capacity. Nanostructured silica nanoparticles are non-toxic and biocompatible, capable of biodegradation in environments containing living organisms [ 72 , 73 ] ( Figure 7 ).…”