Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam

Abstract

The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. Quantitation of the studied drugs and their binary mixtures was performed by integrating the peak areas of the characteristic well-resolved bands:υ(C=O) band at 1773 cm−1for cefepime and ring torsion band at 826 cm−1for metronidazole andυ(C=O) band at 1715 cm−1for cefoperazone and ring torsion band at 1124 cm−1for sulbactam. The results of this work were compared with the relevant spectrophotometric reported methods. This study provides data that can be used for the preparative process monitoring of the studied drugs in various dosage forms.

Characterizing the Bioactive Ingredients in Sesame Oil Affected by Multiple Roasting Methods

“…The major decomposition stage indicates the breakdown of covalent bonds and modified chemical configurations, with the greatest weight loss about 400 °C. Tan et al [ 90 ] reported that the oxidative stability of vegetable oils showed similar results and that the oils that contained high proportions of free fatty acids were more liable to oxidation; the authors determined that liberated FAs show less constant oxidation than FAs bound to glycerol molecules. Fatty acids with elongated carbon chains are more constant as a result of heating degradation than the short-chain FAs attributed to increasing intermolecular dispersal powers [ 91 ].…”

Electrospun Membranes Based on Polycaprolactone, Nano-Hydroxyapatite and Metronidazole

“…Figure 6 b, which details the wavelength range between 2000 and 500 cm −1 , shows the positions of the absorbance peaks more clearly. Thus, Figure 6 a,b reveals MET characteristics like OH (alcohol) stretching band which appears at 3201 cm −1 , C–H (aromatic) stretching at 3099 cm −1 , C–NO 2 and N–O stretching at 1535 cm −1 , CH 2 scissoring at 1471 cm −1 , C–OH and C–O stretching at 1047 cm −1 and C–NO 2 and C–N stretching at 825 cm −1 [ 23 , 24 , 25 ]. In Figure 6 b, the spectrum of PCL-5% nHAP-20% MET and the specific bands of MET can be highlighted more easily.…”

Development of Composite, Reinforced, Highly Drug-Loaded Pharmaceutical Printlets Manufactured by Selective Laser Sintering—In Search of Relevant Excipients for Pharmaceutical 3D Printing

“…In curves obtained for powder mixtures as well as for printlets, two crystallization effects were observed at about 129 • C (the same for the mixture and the sintered sample), 42 • C (for the mixture) and 27 • C (for the sintered sample). From the comparison of crystallization enthalpies of PA12 and Met with those obtained from the mixture and the sintered sample, it could be assumed that the effect at 129 In ATR-IR spectra, Met was easily identified by the intensive bands at 3209 cm −1 (from O-H stretching vibrations), 3100 cm −1 (from C-H stretching vibrations), 1534 cm −1 (from -NO2 asymmetric stretching vibrations), 1472 cm −1 and 1427 cm −1 (from C-H deformation vibrations), 1367 cm −1 (from -NO2 symmetric stretching vibrations), 1186 cm −1 (from C-O stretching vibrations) and 1073 cm −1 (from the ring breathing mode) [47].…”

“…In the spectra of both mixtures, mainly Met bands were observed as well as two characteristic bands at 2971 cm −1 (Figure 6a) and 1637 cm −1 (Figure 6b) from PA12. In ATR-IR spectra, Met was easily identified by the intensive bands at 3209 cm −1 (from O-H stretching vibrations), 3100 cm −1 (from C-H stretching vibrations), 1534 cm −1 (from -NO 2 asymmetric stretching vibrations), 1472 cm −1 and 1427 cm −1 (from C-H deformation vibrations), 1367 cm −1 (from -NO 2 symmetric stretching vibrations), 1186 cm −1 (from C-O stretching vibrations) and 1073 cm −1 (from the ring breathing mode) [47].…”